Pharmaceutical heterogeneous systems I Hydrolysis of aspirin in combination with tablet lubricants in an aqueous suspension

Kornblum, Saul S.; Zoglio, M.A.

doi:10.1002/jps.2600561208

Cited by 45 publications

(9 citation statements)

References 4 publications

(2 reference statements)

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“…The stability of drugs in the presence of solid additives have received considerable attention in the field of pharmaceutics [1,2]. Aspirin is a drug that hydrolyses to salicylic acid and acetic acid in the presence of moisture or water [3,4].…”

Section: Introductionmentioning

confidence: 99%

Density functional study of the adsorption of aspirin on the hydroxylated (001) -quartz surface

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Density functional study of the adsorption of aspirin on the hydroxylated (001) -quartz surface

et al. 2009

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“…This is because acetylsalicylic acid is a moisture-sensitive drug, and its degradation is often associated with the presence of water and/or an alkaline pH condition [42][43][44]. In addition, Kornblum and Zoglio [45] found that in the presence of magnesium stearate, the rate of degradation of acetylsalicylic acid in suspensions was associated with the high solubility of the magnesium salt of acetylsalicylic acid. Presumably, this is due to the fact that a buffer layer around the particles of acetylsalicylic acid was formed, creating an environment that was detrimental to the chemical stability of the compound [46].…”

Section: Hydrolytic Degradation At Basic Phmentioning

confidence: 99%

Lubricants in Pharmaceutical Solid Dosage Forms

2014

Lubricants

177

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Lubrication plays a key role in successful manufacturing of pharmaceutical solid dosage forms; lubricants are essential ingredients in robust formulations to achieve this. Although many failures in pharmaceutical manufacturing operations are caused by issues related to lubrication, in general, lubricants do not gain adequate attention in the development of pharmaceutical formulations. In this paper, the fundamental background on lubrication is introduced, in which the relationships between lubrication and friction/adhesion forces are discussed. Then, the application of lubrication in the development of pharmaceutical products and manufacturing processes is discussed with an emphasis on magnesium stearate. In particular, the effect of its hydration state (anhydrate, monohydrate, dihydrate, and trihydrate) and its powder characteristics on lubrication efficiency, as well as product and process performance is summarized. In addition, the impact of lubrication on the dynamics of compaction/compression processes and on the mechanical properties of compacts/tablets is presented. Furthermore, the online monitoring of magnesium stearate in a blending process is briefly mentioned. Finally, the chemical compatibility of active pharmaceutical ingredient (API) with magnesium stearate and its reactive impurities is reviewed with examples from the literature illustrating the various reaction mechanisms involved.

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“…Incompatibilities of active ingredient with additives can lead to degradation. Kornblum and Zoglio, (1967) studied the potency degradation of Aspirin suspension with lubricant-namely, Aluminum stearate, magnesium stearate, calcium stearate. It was found out that the extent of degradation was more with magnesium stearate.…”

Section: Degradation Of Drugsmentioning

confidence: 99%

Quality Assessment of Solid Pharmaceuticals and Intravenous Fluid Manufacturing in Sub-Saharan Africa

Tella¹,

Salawu²,

Phillips³

et al. 2011

Wide Spectra of Quality Control

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Pharmaceutical heterogeneous systems I Hydrolysis of aspirin in combination with tablet lubricants in an aqueous suspension

Cited by 45 publications

References 4 publications

Density functional study of the adsorption of aspirin on the hydroxylated (001) -quartz surface

Density functional study of the adsorption of aspirin on the hydroxylated (001) -quartz surface

Lubricants in Pharmaceutical Solid Dosage Forms

Quality Assessment of Solid Pharmaceuticals and Intravenous Fluid Manufacturing in Sub-Saharan Africa

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