Pharmaceutical grade sodium [99mTc] pertechnetate from low specific activity 99Mo using an automated 99Mo/99mTc-TCM-autosolex generator

Diversification of 99Mo/99mTc Separation: Non–Fission Reactor Production of 99Mo as a Strategy for Enhancing 99mTc Availability

“…99m Tc can be separated using any one of the established methods (8). Solvent extraction using methyl ethyl ketone is effective and simple, and cost-effective automated modules can be developed for the preparation of high concentrations of no-carrier-added 99m Tc activity (9). Alternatively, solid-phase extraction chromatographic separation also can be adapted (10).…”

PENGARUH AKTIVITAS 99Mo TERHADAP PROFIL RENDEMEN 99mTc PADA GENERATOR 99Mo/99mTc DENGAN KOLOM MATERIAL BERBASIS ZIRKONIUM (MBZ)

“…Beberapa metode telah dikembangkan untuk memisahkan 99m Tc dari 99 Mo hasil aktivasi [10][11][12], salah satunya adalah teknologi generator 99 Mo/ 99m Tc menggunakan Material Berbasis Zirkonium (MBZ) yang ada di Pusat Teknologi Radioisotop dan Radiofarmaka (PTRR) Badan Tenaga Nuklir Nasional (BATAN) [13]. MBZ memiliki kapasitas serap lebih dari 150 mg Molibdenum/gram MBZ dan saat ini masih terus dikembangkan agar dihasilkan paket teknologi yang bisa diproses lebih lanjut hingga menjadi produk yang siap dimanfaatkan oleh masyarakat [14].…”

Pivotal role of separation chemistry in the development of radionuclide generators to meet clinical demands

“…However, this concept has been resurrected with the introduction of automation as a possible alternative to obtaining 99m Tc using (n,g) 99 Mo. 87,88 The renewed impetus for this process is due to its proven effectiveness as a solvent extraction technology. On a similar theme, a 188 W/ 188 Re solvent extraction generator, using the MEK extraction method as used for the 99 Mo/ 99m Tc generator system, has also been fabricated to separate 188 ReO 4…”