1994
DOI: 10.1248/yakushi1947.114.12_1005
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Pharmaceutical Dosage Form Design of Copoly (Lactic/Glycolic Acid) Microspheres. Mechanism of in Vitro Release of Gentamicin

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Cited by 5 publications
(3 citation statements)
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“…It has been shown that changing the dispersion medium from an aqueous solution to an oily medium improved the encapsulation efficiency of tyrotropin‐releasing hormone into PLGA nanospheres from 3% to 40% 62. Nagata et al observed that the terminal free carboxyl group of the polymer (the same type of PLGA was used in our study) is necessary for efficient gentamicin sulfate entrapment in PLGA microspheres 63. For the highly water soluble leuprorelin, NMR measurements recently showed that a rigid structure is formed in the microspheres due to ionic interaction between amino groups of the drug and the terminal carboxylic anions of the polymer 64.…”
Section: Resultsmentioning
confidence: 53%
“…It has been shown that changing the dispersion medium from an aqueous solution to an oily medium improved the encapsulation efficiency of tyrotropin‐releasing hormone into PLGA nanospheres from 3% to 40% 62. Nagata et al observed that the terminal free carboxyl group of the polymer (the same type of PLGA was used in our study) is necessary for efficient gentamicin sulfate entrapment in PLGA microspheres 63. For the highly water soluble leuprorelin, NMR measurements recently showed that a rigid structure is formed in the microspheres due to ionic interaction between amino groups of the drug and the terminal carboxylic anions of the polymer 64.…”
Section: Resultsmentioning
confidence: 53%
“…Also, the haloperidol incorporation values for capped PLGA 50:50 (~8%) and capped PLGA 95:5 (~12%) are comparable, thus indicating that the L:G ratio is less important than the endgroups. The importance of endgroups has previously been suggested for PLGA microspheres loaded with the drugs gentamicin (Nagata S, 1994) and leuprorelin (Takada S, 1998). There is also a report for PLGA nanoparticles in which the end group doubles the protein loading (Gaspar M M, 1998).…”
Section: Drug Incorporation Efficiency and Drug Contentmentioning
confidence: 98%
“…For example, NPs made of COOH terminated PLGA polymer were found to have three times higher incorporation efficiency of Haloperidol compared to the ester terminated ones [17]. The influence of PLGA end groups on the encapsulation efficiency of several drugs such as gentamicin [19], and leuprorelin [20], as well as proteins [21], has been documented. The end group of PLGA is also shown to affect the release kinetics of encapsulated drugs from NPs [17,22].…”
Section: Introductionmentioning
confidence: 99%