Pharmaceutical Development for Phleboprotective and Anti-Inflammatory Gels: Analytical Support of the Technological Process

Abstract

External soft dosage forms with a penetrating effect of different efficacy have proved promising in the treatment of inflammatory diseases. Moreover, there are few such medicines on the modern pharmaceutical market, and replenishment of their assortment is relevant. Objective. The purpose of these studies is to develop external soft dosage forms for various purposes using penetrators, their technological features and analysis. Material and methods. The work used: purified micronized flavonoid fraction (diosmin+flavonoids in terms of hesperidin), which has a phleboprotec-tive effect; Tizol – aquacomplex of titanium glycerosolvate is a metal complex compound with anti-inflammatory and antimicrobial action; L-arginine is an essential amino acid, a nitrogen donor; auxiliary substances: Polyethylene Oxide 400, Polyethylene Oxide 1500, Propylene Glycol-1,2. The studies were carried out using spectrophotometric determination, biopharmaceutical determination of a penetrator in a dental gel. Results. Optimal compositions of ointment and gel were developed, a general technological scheme of production was designed. Based on the analy-sis of the technological scheme, we recorded the critical stages of the process common to both objects. As for the methods for the quantitative anal-ysis of ointment with a flavonoid complex, they are validated. Studies on the microbiological purity of dental gel allowed us to make an unambiguous conclusion about the sterility of the gel. This, in turn, ensures the effectiveness of therapy with such a drug, due to the absence of side microbiological contamination during use, as well as the absence of the risk of concomitant diseases. Conclusion. As a result of the conducted research, compositions of external soft dosage forms of phleboprotective and dental profile containing pene-trating components were developed.