Pharmaceutical Aspects of Green Synthesized Silver Nanoparticles: A Boon to Cancer Treatment

Abstract

Background: Silver nanoparticles (AgNPs) are one of the most investigated nanostructures in recent years, which gives more challenging and promising qualities in different biomedical applications. The AgNPs synthesized by the green approach provide potential healthcare benefits over chemical approaches, including improvement of tissue restoration, drug delivery, diagnosis, environmentally friendly and a boon to cancer treatment. Objective: In the current scenario, the development of safe and effective drug delivery systems is the utmost concern of formulation development scientists as well as clinicians. Methods: Google, Web of Science, PubMed, portals have been searched for potentially relevant literature to get latest developments and updated information related to different aspects of green synthesized AgNPs along with their biomedical applications especially in the treatment of different types of cancers. Results: The present review highlights the latest published research regarding the different green approaches for the synthesis of AgNPs, their characterization techniques as well as various biomedical applications, particularly in cancer treatment. In this context, environment friendly AgNPs are proving themselves as better candidates in terms of size, drug loading and release efficiency, targeting efficiency, minimal drug-associated side effects, pharmacokinetic profiling, and biocompatibility issues. Conclusion: With continuous efforts by multidisciplinary team approaches, nanotechnology-based AgNPs will shed new light on diagnostics and therapeutics in various disease treatments. However, the toxicity issues of AgNPs needs the greatest attention as unanticipated toxic effects must be ruled out for their diversified applications.

Multifunctional Silver Nanoparticles Based on Chitosan: Antibacterial, Antibiofilm, Antifungal, Antioxidant, and Wound-Healing Activities

“…The toxicity of silver nanoparticles loaded with chitosan depends on concentration, species, and particle size [ 71 ]. In the present study, As previously reported by researchers [ 72 ], an increase in nanoparticle concentration increases the cytotoxic effect on normal cell lines in a dose-dependent manner. The half-maximal inhibitory concentrations (IC 50 ) of Chi/Ag-NPs were calculated to be 119.2 µg/mL.…”

Green Synthesis of Silver Nanoparticles Using Randia aculeata L. Cell Culture Extracts, Characterization, and Evaluation of Antibacterial and Antiproliferative Activity

“…There are several studies on the ecological synthesis of AgNP for various applications, particularly in cancer treatment or with antiproliferative activity, proving to be better candidates in terms of size, drug loading and release efficiency, targeting efficiency, minimal side effects associated with the drug, pharmacokinetic profile, and biocompatibility issues [ 75 ]. In this study, the in vitro antiproliferative activity of the AgNPs synthesized with extracts of R. acuelata cell cultures were evaluated at concentrations of 0.3 to 9.2 µg/mL using the human cancer cell lines Hep3b, HepG2, HeLa, and A549, with the IHH line used as a control ( Table 3 ).…”

Nano‐biotechnology in tumour and cancerous disease: A perspective review

“…Another mechanism that has been described for the anticancer potential of SNPs is autophagy‐induced cell degradation leading to cell death. Autophagy is stimulated by green‐synthesized SNPs because the number of autophagolysosomes is increased, leading to the self‐destruction of cancer cells 117,118 . There are numerous methods for the conjugation of anticancer drugs with SNPs, including encapsulation, entrapment, and attachment to the surface of nanoparticles.…”