Pharmaceutical Applications of Shellac: Moisture-Protective and Taste-Masking Coatings and Extended-Release Matrix Tablets

Pearnchob, Nantharat; Siepmann, J.; Bodmeier, Roland

doi:10.1081/ddc-120024188

Cited by 103 publications

(47 citation statements)

References 17 publications

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“…5 Phonograph records composed of shellac and fillers 6 were stamped using a metal stamp, 7 yielding lateral feature sizes in the order of tens of micrometers (see Figure 1). Today, shellac is used as a coating material for drug release 8,9 and is an approved food additive. 10,11 Additionally, shellac already was employed as a substrate and dielectric layer material in environmentally friendly transistors, because of its insulating properties and capability to form smooth surfaces.…”

Section: B Application Areas Of Shellacmentioning

confidence: 99%

Introducing natural thermoplastic shellac to microfluidics: A green fabrication method for point-of-care devices

et al. 2016

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We present a sustainable fabrication method for cheap point-of-care microfluidic systems, employing hot embossing of natural shellac as a key feature of an energyefficient fabrication method that exclusively uses renewable materials as consumables. Shellac is a low-cost renewable biomaterial that features medium hydrophilicity (e.g., a water contact angle of ca. 73 ) and a high chemical stability with respect to common solvents such as cyclohexane or toluene, rendering it an interesting candidate for low-cost microfluidics and a competitor to well-known systems such as paperbased or polydimethylsiloxane-based microfluidics. Moreover, its high replication accuracy for small features down to 30 lm lateral feature size and its ability to form smooth surfaces (surface roughness R a ¼ 29 nm) at low embossing temperatures (glass transition temperature T g ¼ 42.2 C) enable energy-efficient hot embossing of microfluidic structures. Proof-of-concept for the implementation of shellac hot embossing as a green fabrication method for microfluidic systems is demonstrated through the successful fabrication of a microfluidic test setup and the assessment of its resource consumption. Published by AIP Publishing. [http://dx

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Section: B Application Areas Of Shellacmentioning

confidence: 99%

Introducing natural thermoplastic shellac to microfluidics: A green fabrication method for point-of-care devices

et al. 2016

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“…3,4) Although powder or capsule dosage forms are also useful orally, they have the drawback of attaching to the throat or pharynx, indicating that tablets have superior usability; however, elderly people and children often have difficulty swallowing conventional tablets or capsules. 5) In particular, patients with oesophageal problems require oral dosage forms that can be swallowed more easily.…”

mentioning

confidence: 99%

Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Ester as a Disintegration-Accelerating Agent

Koseki

Onishi

Uchida

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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It was attempted to produce novel furosemide (FS) fast-disintegrating tablets by direct compression. The combination of FS, microcrystalline cellulose, croscarmellose sodium and xylitol was used as the basic formulation, and sucrose stearic acid ester (SSE) was chosen as an additional additive. The tablets with SSE were prepared by the simple addition of SSE, using a lyophilized mixture of FS and SSE or using a FS/SSE mixture obtained by evaporation of their ethanol solution. Only the tablets, produced using the FS/SSE mixture obtained by organic solvent (ethanol) evaporation, showed hardness of more than 30 N and a disintegration time of less than 20 s, which were the properties suitable for fast-disintegrating tablets. These properties were considered to result from well-mixed and fine-powdered SSE and FS.

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“…This makes shellac suitable for use even in foods or confectionaries. Shellac has excellent film-forming properties, high gloss, and poor permeability to gases and water vapor (8,9).…”

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confidence: 99%

Physicochemical Properties of Various Shellac Types

Farag¹,

Leopold

2009

Dissolution Technol.

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Shellac in its acid form undergoes aging, resulting in the change of its physicochemical properties. Therefore, various shellac types were investigated as free films prepared from ammoniacal solutions and as micronized powder in its acid form. Due to its acidic character, shellac shows a pH-dependent solubility. The dissolution properties of shellac films prepared from ammoniacal solution were investigated at various pH values using a dissolution apparatus with basket holder. Micronized shellac in its acid form was analyzed using the intrinsic dissolution method (Ph. Eur.) with a paddleover-disk apparatus. The dissolution properties of the investigated shellac types were correlated with their acid values and their thermal properties. Aging of shellac results in an increase in the glass transition temperature and a decrease in the acid value and the solubility. However, the extent of this change in physicochemical properties depends on the type of shellac, its origin, and type of refining process. Besides the acid value and the glass transition temperature, the intrinsic dissolution rate is an important parameter for the characterization of different shellac types.

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Pharmaceutical Applications of Shellac: Moisture-Protective and Taste-Masking Coatings and Extended-Release Matrix Tablets

Cited by 103 publications

References 17 publications

Introducing natural thermoplastic shellac to microfluidics: A green fabrication method for point-of-care devices

Introducing natural thermoplastic shellac to microfluidics: A green fabrication method for point-of-care devices

Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Ester as a Disintegration-Accelerating Agent

Physicochemical Properties of Various Shellac Types

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