Pharmaceutical Applications of In Vivo EPR

Mäder, Karsten; Gallez, Bernard

doi:10.1007/978-1-4615-0061-2_19

Cited by 14 publications

(14 citation statements)

References 88 publications

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“…34,107,108 Similarly the monitoring of the polymerization process in bone cement formation could be followed to provide direct information on the status of this complex therapeutic intervention. 109 It is likely that in vivo EPR could be of great practical use for both the development of implanted therapeutic systems and for monitoring the status of implants in individual patients.…”

Section: Characterization Of Drug Delivery Systemsmentioning

confidence: 99%

Clinical applications of EPR: overview and perspectives

et al. 2004

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The development and use of in vivo techniques for strictly experimental applications in animals has been very successful, and these results now have made possible some very attractive potential clinical applications. The area with the most obvious immediate, effective and widespread clinical use is oximetry, where EPR almost uniquely can make repeated and accurate measurements of pO 2 in tissues. Such measurements can provide clinicians with information that can impact directly on diagnosis and therapy, especially for oncology, peripheral vascular disease and wound healing. The other area of immediate and timely importance is the unique ability of in vivo EPR to measure clinically significant exposures to ionizing radiation 'after-the-fact', such as may occur due to accidents, terrorism or nuclear war. There are a number of other capabilities of in vivo EPR that also potentially could become extensively used in human subjects. In pharmacology the unique capabilities of in vivo EPR to detect and characterize free radicals could be applied to measure free radical intermediates from drugs and oxidative process. A closely related area of potential widespread applications is the use of EPR to measure nitric oxide. These often unique capabilities, combined with the sensitivity of EPR spectra to the immediate environment (e.g. pH, molecular motion, charge) have already resulted in some very productive applications in animals and these are likely to expand substantially in the near future. They should provide a continually developing base for extending clinical uses of in vivo EPR. The challenges for achieving full implementation include adapting the spectrometer for safe and comfortable measurements in human subjects, achieving sufficient sensitivity for measurements at the sites of the pathophysiological processes that are being measured, and establishing a consensus on the clinical value of the measurements.

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Section: Characterization Of Drug Delivery Systemsmentioning

confidence: 99%

Clinical applications of EPR: overview and perspectives

et al. 2004

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“…Oxygen partial pressure is a very important parameter in most metabolic processes. Furthermore, certain drugs have different pharmacological effects depending on the local pO 2 and pH (6). Recent advances in ESR combined with new insights and information from cell and molecular biology mean that critical determinants for diagnosis and therapy can now be probed.…”

Section: Introductionmentioning

confidence: 99%

Electron Spin Relaxation Time Measurements Using Radiofrequency Longitudinally Detected ESR and Application in Oximetry

Panagiotelis

Nicholson

Hutchison

2001

Journal of Magnetic Resonance

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“…A pH-sensitive spin probe has been used with model systems for biological applications at low frequency. An extension of this work may find practical application in pharmaceutical studies, as pH is known to be a key parameter governing drug delivery [79] .…”

Section: Site-specific Agentsmentioning

confidence: 99%

“…The primary limitations to the clinical use of EPRI, sample heating and small penetration depths/small sample sizes are being overcome with rapid instrumental developments, such as low field resonators, three-dimensional EPRI techniques, and other techniques to introduce spectral and temporal components to the three-dimensional image [112,113] .…”

Section: Summary and Prospectsmentioning

confidence: 99%