Pharmaceutical applications of electrospinning

Nangare, Sopan; Jadhav, Namdeo; Ghagare, Pravin; Muthane, Tejashwini

doi:10.1016/j.pharma.2019.07.002

Cited by 23 publications

(24 citation statements)

References 56 publications

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“…From its inception, cancer treatment is still a challenging field in the era of biomedical science. Due to the ineffectiveness of currently engaged therapeutic strategies, a large number of deaths have been occurring each year [51]. Therefore, there is an urge to develop an advanced substitute to resolve cancer ineffective treatment issues.…”

Section: Anticancer Drug Deliverymentioning

confidence: 99%

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Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Nangare

Dugam

2020

Futur J Pharm Sci

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Background Scientists are constantly looking for the introduction of unique drug delivery systems for the existing drug molecule. Since the skin is one of the primary and essential organs of the human body, it needs successful research development for the delivery of the drug. While the skin is assumed a human body’s multifunctional organ, it has minimal permeability across the stratum corneum (SC). Since this is an influential barrier for the active agent, several carrier platforms to surmount this obstacle have been created. Invasomes are the liposomal vesicles, which incorporate small quantities of ethanol and terpenes or a mixture of terpenes, as potentials for improved penetration of the skin. The rate of penetration of invasomes through the skin is significantly greater than that of liposomes and ethosomes. Invasomes focus on providing a series of benefits namely enhanced drug effectiveness, increased conformity, and ease for patients. Main body The present article portrays insights of invasomes which include composition and preparation methods of invasomes. The article gives a brief review of the penetration mechanism, synthesis process, and characterizations of invasomes. The article gives a point by point audit about pharmaceutical applications, viz. anticancer, antihypertensive, anti-acne, vitamin analog, anticholinergic, antioxidant, etc. The pharmacokinetic properties of invasomes have also been described. Conclusion The key goal of an invasome-based delivery system is not only to strengthen the efficacy and safety of the drug but also to dramatically increase patient conformity and the therapeutic value to a significant extent. The delivery of drugs via the skin membrane in advanced drug delivery systems is a fascinating fact. Many pharmaceutical studies have shown that plentiful drug molecules are less soluble, have less bioavailability and stability, have less penetration, etc. Therefore, a new form of dosage with exceptional characteristics like invasomes can be created. Graphical abstract

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Section: Anticancer Drug Deliverymentioning

confidence: 99%

“…Anti-hypertensive are used to treat elevated hypertension. It has numerous problems such as low aqueous solubility, low bioavailability, short biological half-life, low permeability, and a list of undesirable side effects [51]. This can be waved off using a suitable route for delivery and formulation.…”

Section: Delivery Of Anti-hypertensive Agentmentioning

confidence: 99%

Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Nangare

Dugam

2020

Futur J Pharm Sci

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“…Electrospinning is an economical, practical, and simple method for the preparation of nanofibers [180][181][182][183]. The biological irony is that all human tissues and organs undergo deposition in nanofibrous forms (i.e., bone, dentin, collagen, cartilage, and skin) [184].…”

Section: Theranostic Electrospun Nanofibersmentioning

confidence: 99%

“…Biosensors could provide new vistas in wound care via detecting bacterial wound infections [193]. Electrospun fibers could be a winning strategy in wound dressing applications, hitting both goals of being physical barriers that prevent wound-associated infections and acting as a 3D scaffold that replaces the extracellular matrix (ECM) of the skin of the patient [181,183,185,190]. Alteration in the well-orchestrated skin microbiota composition could be associated with the pathogenesis of inflammatory skin disease [194].…”

Section: Theranostic Electrospun Nanofibersmentioning

confidence: 99%

“…[182]. Fifth, even with the ongoing research for the antibacterial electrospun nanofibers, data about their in vivo safety assessments are limited [182,183,192]. Therefore, even with the agile features of biopolymeric electrospun nanofibers that could shine in wound dressing applications, the electrospun fibers' biocompatibility remains a potential issue.…”

Section: Nanotheranostics' Challengesmentioning

confidence: 99%

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Nanotheranostics: A Possible Solution for Drug-Resistant Staphylococcus aureus and their Biofilms?

et al. 2021

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Staphylococcus aureus is a notorious pathogen that colonizes implants (orthopedic and breast implants) and wounds with a vicious resistance to antibiotic therapy. Methicillin-resistant S. aureus (MRSA) is a catastrophe mainly restricted to hospitals and emerged to community reservoirs, acquiring resistance and forming biofilms. Treating biofilms is problematic except via implant removal or wound debridement. Nanoparticles (NPs) and nanofibers could combat superbugs and biofilms and rapidly diagnose MRSA. Nanotheranostics combine diagnostics and therapeutics into a single agent. This comprehensive review is interpretative, utilizing mainly recent literature (since 2016) besides the older remarkable studies sourced via Google Scholar and PubMed. We unravel the molecular S. aureus resistance and complex biofilm. The diagnostic properties and detailed antibacterial and antibiofilm NP mechanisms are elucidated in exciting stories. We highlight the challenges of bacterial infections nanotheranostics. Finally, we discuss the literature and provide “three action appraisals”. (i) The first appraisal consists of preventive actions (two wings), avoiding unnecessary hospital visits, hand hygiene, and legislations against over-the-counter antibiotics as the general preventive wing. Our second recommended preventive wing includes preventing the adverse side effects of the NPs from resistance and toxicity by establishing standard testing procedures. These standard procedures should provide breakpoints of bacteria’s susceptibility to NPs and a thorough toxicological examination of every single batch of synthesized NPs. (ii) The second appraisal includes theranostic actions, using nanotheranostics to diagnose and treat MRSA, such as what we call “multifunctional theranostic nanofibers. (iii) The third action appraisal consists of collaborative actions.

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Mechanical Properties of Electrospun Fibers—A Critical Review

2021

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The mechanical properties of electrospun fibers play an important role in determining their applications. Most of the reported literature measures the mechanical properties of electrospun mats, scaffolds, or films instead of single fibers; however, a basic understanding of the relationship between the mechanical properties of the single fiber and that of the mat is critical to obtain precise information for choosing their application. This Review aims to evaluate the reported mechanical properties of electrospun fibers and the variables that influence those properties. An overview on the recent inputs in the development of mechanical properties of electrospun fibers is given, illustrating attempts to tailor mechanical properties of the fibers and/or mats. The necessity of determining flexible and reliable testing methods to establish testing standards for obtaining consistent and reliable data for both electrospun fibers and mats is also highlighted.

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Pharmaceutical applications of electrospinning

Cited by 23 publications

References 56 publications

Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Smart invasome synthesis, characterizations, pharmaceutical applications, and pharmacokinetic perspective: a review

Nanotheranostics: A Possible Solution for Drug-Resistant Staphylococcus aureus and their Biofilms?

Mechanical Properties of Electrospun Fibers—A Critical Review

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