Pharmaceutical applications of cyclodextrins and their derivatives

Dhiman, Priya; Bhatia, Meenakshi

doi:10.1007/s10847-020-01029-3

Cited by 50 publications

(26 citation statements)

References 150 publications

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“…As excipients, the most relevant use of CDs is as a complexing agent to improve drug solubility and bioavailability; the CD complexation can also be exploited to ameliorate the stability of drugs, in terms of reduction of the evaporation of volatile substances or protection of drugs from light and/or oxygen-induced degradation, as well as to cover bad flavors or scents or transform liquid substances into powders and, in general, to prevent incompatibility reactions between substances in the formulation [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

et al. 2021

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Cyclodextrins (CDs) are oligosaccharides widely used in the pharmaceutical field. In this review, a detailed examination of the literature of the last two decades has been made to understand the role of CDs in nasal drug delivery systems. In nasal formulations, CDs are used as pharmaceutical excipients, as solubilizers and absorption promoters, and as active ingredients due to their several biological activities (antiviral, antiparasitic, anti-atherosclerotic, and neuroprotective). The use of CDs in nasal formulations allowed obtaining versatile drug delivery systems intended for local and systemic effects, as well as for nose-to-brain transport of drugs. In vitro and in vivo models currently employed are suitable to analyze the effects of CDs in nasal formulations. Therefore, CDs are versatile pharmaceutical materials, and due to the continual synthesis of new CDs derivatives, the research on the new nasal applications is an interesting field evolving in the coming years, to which Italian research will still contribute.

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Section: Introductionmentioning

confidence: 99%

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

et al. 2021

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“…CDs can be divided into two main classes: natural CDs, namely α, β and γ-CD ( Figure 2 ), and semisynthetic CDs obtained through the derivatization of the hydroxyl residues using various groups. Depending on the groups grafted to the CDs surface, the obtained derivatives possess several advantages such as increased inclusion capacity for certain compounds, superior water solubility (HP-β-CD) or lipophilicity (Methyl-β-CD) [ 62 ].…”

Section: Cyclodextrins—classification and Physicochemical Propertiesmentioning

confidence: 99%

The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents

Prodea

Mioc

Banciu

et al. 2022

IJMS

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Triterpenic compounds stand as a widely investigated class of natural compounds due to their remarkable therapeutic potential. However, their use is currently being hampered by their low solubility and, subsequently, bioavailability. In order to overcome this drawback and increase the therapeutic use of triterpenes, cyclodextrins have been introduced as water solubility enhancers; cyclodextrins are starch derivatives that possess hydrophobic internal cavities that can incorporate lipophilic molecules and exterior surfaces that can be subjected to various derivatizations in order to improve their biological behavior. This review aims to summarize the most recent achievements in terms of triterpene:cyclodextrin inclusion complexes and bioconjugates, emphasizing their practical applications including the development of new isolation and bioproduction protocols, the elucidation of their underlying mechanism of action, the optimization of triterpenes’ therapeutic effects and the development of new topical formulations.

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“…The hydrophobic central cavity of a CD molecule can encapsulate various lipophilic molecules by inclusion complex formation. Besides various low molecular-weight drugs that are the most common guests [30,31], inclusion complexation can also occur with different lipids, including free fatty acids, their mono-, di-, and triglycerides, and phospholipids [29,[32][33][34]. Such interactions are dependent on the structure Fig.…”

Section: Interaction Of Cyclodextrins With Lipidsmentioning

confidence: 99%

Cyclodextrin-based Pickering emulsions: functional properties and drug delivery applications

Jug

Yoon

Jackman

2021

J Incl Phenom Macrocycl Chem

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Cyclodextrins (CDs) are biocompatible, cyclic oligosaccharides that are widely used in various industrial applications and have intriguing interfacial science properties. While CD molecules typically have low surface activity, they are capable of stabilizing emulsions by inclusion complexation of oil-phase components at the oil/water interface, which results in Pickering emulsion formation. Such surfactant-free formulations have gained considerable attention in recent years, owing to their enhanced physical stability, improved tolerability, and superior environmental compatibility compared to conventional, surfactant-based emulsions. In this review, we critically describe the latest insights into the molecular mechanisms involved in CD stabilization of Pickering emulsions, including covering practical aspects such as methods to prepare CD-based Pickering emulsions, lipid encapsulation, and relevant stability issues. In addition, the rheological and textural features of CD-based Pickering emulsions are discussed and particular attention is focused on promising examples for drug delivery, cosmetic, and nutraceutical applications. The functionality of currently developed CD-based Pickering emulsions is also summarised, including examples such as antifungal uses, and we close by discussing emerging possibilities to utilize the molecular encapsulation of CD-based emulsions for translational medicine applications in the antiviral and antibacterial spaces.

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Pharmaceutical applications of cyclodextrins and their derivatives

Cited by 50 publications

References 150 publications

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents

Cyclodextrin-based Pickering emulsions: functional properties and drug delivery applications

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