Pharmaceutical applications of chitosan on medical implants: A viable alternative for construction of new biomaterials?

de Oliveira, Weslley Felix; Sales Albuquerque, Priscilla Barbosa; Ribeiro Rodrigues, Natalie Emanuelle; dos Santos Silva, Priscila Marcelino; Kennedy, John F.; dos Santos Correia, Maria Tereza; Breitenbach Barroso Coelho, Luana Cassandra

doi:10.1016/j.carpta.2023.100407

Cited by 1 publication

(1 citation statement)

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“…Chitosan's structure also facilitates the formation of polyelectrolyte complexes with oppositely charged polymers, leading to the development of advanced materials with tailored properties. Understanding the intricacies of chitosan's structure is paramount for optimizing its performance in diverse applications in pharma [60,93,94], biomedicine [95,96], environmentally friendly agricultural formulation [53], or even wastewater treatment [97]. Similar to chitin, chitosan also exhibits both parallel and antiparallel configurations of its chains (referred to as α, β, and γ) [27,75].…”

Section: Introductionmentioning

confidence: 99%

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Durante-Salmerón,

Fraile-Gutiérrez,

Gil-Gonzalo

et al. 2024

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Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans and the cell walls of fungi, have garnered considerable attention in pharmaceutical circles due to their biocompatibility, biodegradability, and versatile properties. Deep eutectic solvents (DESs), emerging green solvents composed of eutectic mixtures of hydrogen bond acceptors and donors, offer promising avenues for enhancing the solubility and functionality of chitin and chitosan in pharmaceutical formulations. This review delves into the potential of utilizing DESs as solvents for chitin and chitosan, highlighting their efficiency in dissolving these polymers, which facilitates the production of novel drug delivery systems, wound dressings, tissue engineering scaffolds, and antimicrobial agents. The distinctive physicochemical properties of DESs, including low toxicity, low volatility, and adaptable solvation power, enable the customization of chitin and chitosan-based materials to meet specific pharmaceutical requirements. Moreover, the environmentally friendly nature of DESs aligns with the growing demand for sustainable and eco-friendly processes in pharmaceutical manufacturing. This revision underscores recent advances illustrating the promising role of DESs in evolving the pharmaceutical applications of chitin and chitosan, laying the groundwork for the development of innovative drug delivery systems and biomedical materials with enhanced efficacy and safety profiles.

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