Pharmaceutical applications of a nanospectroscopic technique: Surface-enhanced Raman spectroscopy

Yılmaz, Hülya; Yılmaz, Deniz; Taşkin, Irem Çulha; Çulha, Mustafa

doi:10.1016/j.addr.2022.114184

Cited by 31 publications

(10 citation statements)

References 110 publications

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“…SERS/SERRS NPs are composed of Raman reporter molecules adsorbed on the surface of metal cores (gold or silver NPs), and application of the contrast agent SERRS-NPs can significantly enhance the Raman imaging effect. Enhanced SERS/SERRS signals can be used as tumour markers to guide surgery, and they have high sensitivity and resolution for detecting tumour margins [116]. Harmsen et al demonstrated that a single dose of SERRS-NPs with high sensitivity could help to effectively detect and delineate small gastrointestinal precancerous lesions in animal models by applying the InVia Raman imaging system, Raman endoscope and Raman/ white-light imaging [117].…”

Section: Intraoperative Imaging and Navigationmentioning

confidence: 99%

Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer

Deng

Jiang

et al. 2022

J Nanobiotechnol

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Gastrointestinal cancer (GIC) is a common malignant tumour of the digestive system that seriously threatens human health. Due to the unique organ structure of the gastrointestinal tract, endoscopic and MRI diagnoses of GIC in the clinic share the problem of low sensitivity. The ineffectiveness of drugs and high recurrence rates in surgical and drug therapies are the main factors that impact the curative effect in GIC patients. Therefore, there is an urgent need to improve diagnostic accuracies and treatment efficiencies. Nanotechnology is widely used in the diagnosis and treatment of GIC by virtue of its unique size advantages and extensive modifiability. In the diagnosis and treatment of clinical GIC, surface-enhanced Raman scattering (SERS) nanoparticles, electrochemical nanobiosensors and magnetic nanoparticles, intraoperative imaging nanoparticles, drug delivery systems and other multifunctional nanoparticles have successfully improved the diagnosis and treatment of GIC. It is important to further improve the coordinated development of nanotechnology and GIC diagnosis and treatment. Herein, starting from the clinical diagnosis and treatment of GIC, this review summarizes which nanotechnologies have been applied in clinical diagnosis and treatment of GIC in recent years, and which cannot be applied in clinical practice. We also point out which challenges must be overcome by nanotechnology in the development of the clinical diagnosis and treatment of GIC and discuss how to quickly and safely combine the latest nanotechnology developed in the laboratory with clinical applications. Finally, we hope that this review can provide valuable reference information for researchers who are conducting cross-research on GIC and nanotechnology.

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Section: Intraoperative Imaging and Navigationmentioning

confidence: 99%

Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer

Deng

Jiang

et al. 2022

J Nanobiotechnol

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“…For instance, the concentration of most metabolites in biofluids; serum, urine or tear is below the detection limit of the technique. However, a phenomenon called Surface-enhanced Raman scattering (SERS), discovered in early 1970s, enhances RS up to 10 14 times and can be a remedy for this deficiency of the technique by bringing the molecule of interest into contact or very close vicinity of a nanostructured noble metal surface, such as gold or silver [ 22 , 23 , 24 , 25 ]. With its extremely high sensitivity, SERS has been employed to solve numerous challenging detection problems in a variety of fields, including biotechnology and medicine [ 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Label-Free Surface Enhanced Raman Spectroscopy for Cancer Detection

Avci

Yılmaz

Şahiner

et al. 2022

Cancers

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Blood is a vital reservoir housing numerous disease-related metabolites and cellular components. Thus, it is also of interest for cancer diagnosis. Surface-enhanced Raman spectroscopy (SERS) is widely used for molecular detection due to its very high sensitivity and multiplexing properties. Its real potential for cancer diagnosis is not yet clear. In this study, using silver nanoparticles (AgNPs) as substrates, a number of experimental parameters and scenarios were tested to disclose the potential for this technique for cancer diagnosis. The discrimination of serum samples from cancer patients, healthy individuals and patients with chronic diseases was successfully demonstrated with over 90% diagnostic accuracies. Moreover, the SERS spectra of the blood serum samples obtained from cancer patients before and after tumor removal were compared. It was found that the spectral pattern for serum from cancer patients evolved into the spectral pattern observed with serum from healthy individuals after the removal of tumors. The data strongly suggests that the technique has a tremendous potential for cancer detection and screening bringing the possibility of early detection onto the table.

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“…Surface-enhanced Raman scattering (SERS), as an accurate analytical technique, is gaining widespread attention owing to its numerous advantages, including specicity, antiinterference, high sensitivity and multi-component analysis. [1][2][3][4] SERS has been applied in the elds of medical diagnostics, toxic dye detection, environmental monitoring, etc. [5][6][7][8][9] SERS signal amplication is mainly attributed to electromagnetic and chemical enhancement.…”

Section: Introductionmentioning

confidence: 99%

Regulated synthesis of an Au NB-DT@Ag bimetallic core-molecule–shell nanostructure for reliable SERS detection

Ren

Sun

et al. 2023

Anal. Methods

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Pharmaceutical applications of a nanospectroscopic technique: Surface-enhanced Raman spectroscopy

Cited by 31 publications

References 110 publications

Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer

Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer

Label-Free Surface Enhanced Raman Spectroscopy for Cancer Detection

Regulated synthesis of an Au NB-DT@Ag bimetallic core-molecule–shell nanostructure for reliable SERS detection

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