Pharmaceutical and drug delivery applications of chitosan biopolymer and its modified nanocomposite: A review

Kedir, Welela Meka; Abdi, Gamachu Fikadu; Goro, Meta Mamo; Tolesa, Leta Deressa

doi:10.1016/j.heliyon.2022.e10196

Cited by 38 publications

(17 citation statements)

References 119 publications

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“…Chitosan nanoparticles are formed by the interaction of positively charged chitosan with negatively charged molecules such as DNA, RNA, and drugs, via electrostatic interactions [ 1 , 59 , 84 , 85 , 86 , 87 ]. These nanoparticles can be administered to the body via various routes such as oral, topical, or injection [ 78 , 88 , 89 ]. Upon administration, chitosan nanoparticles protect the encapsulated drugs from degradation and enhance their absorption and distribution [ 75 , 77 ].…”

Section: Chitosan-based Nanosystem Of Smart Drug Delivery Systemmentioning

confidence: 99%

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

et al. 2023

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Despite recent advances, cancer remains the primary killer on a global scale. Numerous forms of research have been conducted to discover novel and efficient anticancer medications. The complexity of breast cancer is a major challenge which is coupled with patient-to-patient variations and heterogeneity between cells within the tumor. Revolutionary drug delivery is expected to provide a solution to that challenge. Chitosan nanoparticles (CSNPs) have prospects as a revolutionary delivery system capable of enhancing anticancer drug activity and reducing negative impacts on normal cells. The use of smart drug delivery systems (SDDs) as delivering materials to improve the bioactivity of NPs and to understand the intricacies of breast cancer has garnered significant interest. There are many reviews about CSNPs that present various points of view, but they have not yet described a series in cancer therapy from cell uptake to cell death. With this description, we will provide a more complete picture for designing preparations for SDDs. This review describes CSNPs as SDDSs, enhancing cancer therapy targeting and stimulus response using their anticancer mechanism. Multimodal chitosan SDDs as targeting and stimulus response medication delivery will improve therapeutic results.

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Section: Chitosan-based Nanosystem Of Smart Drug Delivery Systemmentioning

confidence: 99%

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

et al. 2023

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“…They exhibit antibacterial, immunostimulating, antitumor, wound healing, and other properties [ 4 , 29 ]. The unique properties of this biopolymer lead to its increased use in many fields: the food industry and nutrition [ 26 ], medicine [ 29 , 30 , 31 ] and biomedicine [ 20 , 32 , 33 ], pharmacy [ 13 ], cosmetology [ 11 ], agriculture [ 34 , 35 ], paper industries and functional textiles [ 36 , 37 ], the edible film industry and packaging [ 38 ], environmental chemistry [ 39 ], biotechnology [ 40 ], nanotechnology [ 41 ], and aquaculture [ 4 , 26 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Heterogeneous Alkaline Deacetylation of Chitin: A Review

et al. 2023

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This review provides an analysis of experimental results on the study of alkaline heterogeneous deacetylation of chitin obtained by the authors and also published in the literature. A detailed analysis of the reaction kinetics was carried out considering the influence of numerous factors: reaction reversibility, crystallinity and porosity of chitin, changes in chitin morphology during washing, alkali concentration, diffusion of hydroxide ions, and hydration of reacting particles. A mechanism for the chitin deacetylation reaction is proposed, taking into account its kinetic features in which the decisive role is assigned to the effects of hydration. It has been shown that the rate of chitin deacetylation increases with a decrease in the degree of hydration of hydroxide ions in a concentrated alkali solution. When the alkali concentration is less than the limit of complete hydration, the reaction practically does not occur. Hypotheses have been put forward to explain the decrease in the rate of the reaction in the second flat portion of the kinetic curve. The first hypothesis is the formation of “free” water, leading to the hydration of chitin molecules and a decrease in the reaction rate. The second hypothesis postulates the formation of a stable amide anion of chitosan, which prevents the nucleophilic attack of the chitin macromolecule by hydroxide ions.

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“…The hydrogel or film nanocomposites based on polymer/clay mixtures have a great potential for a variety of applications including drug delivery [ 1 ], wound dressing [ 2 ], bone tissue engineering [ 3 ], active food packaging [ 4 ], contaminant adsorption [ 5 , 6 ]. For such applications, it is preferable to use natural polymers which have low cost due to their abundance in nature, low toxicity, and biodegradable and biocompatible nature.…”

Section: Introductionmentioning

confidence: 99%

Development of Hybrid Materials Based on Chitosan, Poly(Ethylene Glycol) and Laponite® RD: Effect of Clay Concentration

Morariu¹,

Brunchi²,

Honciuc³

et al. 2023

Polymers

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In the context of increasing interest in biomaterials with applicability in cosmetics and medicine, this research aims to obtain and characterize some hybrid materials based on chitosan (CS) (antibacterial, biocompatible, and biodegradable), poly(ethylene glycol) (PEG) (non-toxic and prevents the adsorption of protein and cell) and Laponite® RD (Lap) (bioactive). The rheological properties of the starting dispersions were investigated and discussed related to the interactions developed between components. All samples exhibited gel-like properties, and the storage modulus of CS/PEG dispersion increased from 6.6 Pa to 657.7 Pa by adding 2.5% Lap. Structural and morphological characterization of the films, prepared by solution casting method, was performed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and polarized light microscopy (POM). These analyses proved the incorporation of Lap into CS/PEG films and revealed the morphological changes of the films by the addition of clay. Thereby, at the highest Lap concentration (43.8%), the “house of cards” structure formed by Lap platelets, which incorporate chitosan chains, as evidenced by SEM and POM. Two stages of degradation between 200 °C and 410 °C were evidenced for the films with Lap concentration higher than 38.5%, explained by the existence of a clay-rich phase (given by the clay network) and chitosan-rich one (due to the intercalation of chitosan in the clay network). CS/PEG film with 43.8% Lap showed the highest swelling degree of 240.7%. The analysis of the obtained results led to the conclusion that the addition of clay to the CS/PEG films increases their stability in water and gives them greater thermal stability.

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Pharmaceutical and drug delivery applications of chitosan biopolymer and its modified nanocomposite: A review

Cited by 38 publications

References 119 publications

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy

Mechanism of Heterogeneous Alkaline Deacetylation of Chitin: A Review

Development of Hybrid Materials Based on Chitosan, Poly(Ethylene Glycol) and Laponite® RD: Effect of Clay Concentration

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