Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection

Abstract

The present study aimed to discuss and compare the effects and expenses of different antibiotic regimens in the treatment of lower respiratory tract infection (LRTI). A retrospective analysis was performed on 200 patients diagnosed with LRTI and treated at the Department of Respiratory Medicine of Dongying People's Hospital from February 2015 to May 2017. The patients were randomly divided into Group A, Group B, Group C and Group D, with 50 cases in each group, and were treated with ceftriaxone sodium, ceftizoxime sodium, levofloxacin and azithromycin, respectively. Venous blood of patients was collected. White blood cells (WBC) of venous blood were detected using a hematology analyzer and C-reactive protein (CRP) was tested with latex immunoturbidimetry. Moreover, therapeutic effects and drug costs of four different antibiotics were compared. No adverse reactions occurred to patients in the four groups during the treatment process. The value at each time point after treatment was significantly decreased compared with that at the previous time point before treatment within the group (P<0.01). The treatment expenses of patients in Group A, Group B and Group D were significantly increased compared with those in Group C (P<0.01), the treatment expenses of patients in Group B and Group D were significantly increased compared with those in Group A (P<0.01) and the treatment expenses of patients in Group D were significantly increased compared with those in Group B (P<0.01). Ceftriaxone sodium, ceftizoxime sodium, levofloxacin and azithromycin all have a good antimicrobial efficacy. The treatment condition of LRTI can be dynamically monitored by WBC and CRP which can accurately reflect the progression condition of patients' illness and the treatment effect. In economic terms, the treatment cost of levofloxacin is the lowest; thus, it is worthy of clinical popularization and application.

Diagnostic value of loop-mediated isothermal amplification in detecting lower respiratory pathogens

“…Respiratory tract infections can alter pulmonary physiology and are recognized as the main cause of lung disease exacerbations [2][3][4]. Lower respiratory tract infection (LRTI) is the most common type of respiratory infection caused by microorganisms, such as bacteria and viruses [5]. The severity of respiratory infection varies significantly with the type of microorganisms and its treatment depends on the cause of the infection [6].…”

Meta-Analysis on the Chinese Herbal Formula Xiaoer-Feike Granules as a Complementary Therapy for Children With Acute Lower Respiratory Infections

“…However, because patients are often desperate for a speedy recovery, they are often irrationally prescribed antibiotics. This overuse of antibiotics worldwide has gradually enhanced the drug resistance of ALRI pathogens, which has significantly increased ALRI infection rates (Zhang L. et al, 2018). In the long run, the benefits from CM as led by antibiotics are likely to be challenged.…”