Pharmaceutical Analysis and Diabetes Mellitus - A Review

Abstract

Context: Current review focuses on the importance of pharmaceutical analytical techniques in the diagnosis of diabetes and the study of antidiabetic drugs. Objective: The main objective of the review is to compile the different analytical tools such as UV-spectroscopy, Fourier-transform infrared (FT-IR), nuclear magnetic resonance (NMR), liquid chromatography-mass spectrometry (LC-MS), gas chromatography (GC)-MS, and electrophoresis that are used to diagnose diabetes using different analytical methods. It also attempts to provide information on the assay of antidiabetic drugs by various analytical techniques and thus helps in the development of novel methods for the study of newer drugs molecules having antidiabetic activity. Methods: The blood sample is subjected to centrifugation to collect the serum before any analytical estimation of antidiabetic drugs. The different types of diabetes were diagnosed using various analytical techniques such as UV-spectroscopy, FT-IR, NMR, LC-MS, GC-MS, and electrophoresis. Results: Different analytical methods that were reported in the literature, were succinctly discussed about the quantification of various antidiabetic drugs. These methods were also employed for the determination of antidiabetic drugs in the research field for the study of actives pharmaceutical ingredients, marketing dosage forms, and post-marketed dosage forms. Conclusion: This review is compiled in such a manner such that it helps the analysts to diagnose diabetes using different analytical techniques and also to study various antidiabetic drugs in the pharmaceutical research field. It also attempts to provide information about different active pharmaceutical ingredients, marketing dosage forms, and post-marketed dosage forms.