Pharmaceutical acrylic beads obtained by suspension polymerization containing cellulose nanowhiskers as excipient for drug delivery

Villanova, Janaína Cecília Oliveira; Ayres, Eliane; Carvalho, Sandhra M.; Patrício, Pedro; Pereira, Fabiano Vargas; Oréfice, Rodrigo Lambert

doi:10.1016/j.ejps.2011.01.005

Cited by 66 publications

(16 citation statements)

References 49 publications

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“…Large specific surface area, high aspect ratio and high capacity to form structured nets make cellulosic nanofibrils excellent low-cost and non-toxic reinforcement agents (Chang et al, 2010;Chang et al, 2010). This class of materials presents micrometric lengths and nanometric widths, leading to interest potential for several applications, including drugs (Villanova et al, 2011), dietary food (Okiyama et al, 1993), special papers (Nguyen and Tan, 2009), reinforcement in packaging/films (Siro and Plackett, 2010;Syverud et al, 2011) and polymeric matrices (Orts et al, 2005;Azizi Samir et al, 2005;Siqueira et al, 2010).…”

Section: Introductionmentioning

confidence: 98%

Starch/PVA-based nanocomposites reinforced with bamboo nanofibrils

Guimarães

Botaro

Novack

et al. 2015

Industrial Crops and Products

141

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a b s t r a c tThis work aimed to evaluate the effect of including different concentrations of bamboo nanofibrils on physical, mechanical, morphological and structural properties of nanocomposites from cassava starch and polyvinyl alcohol (PVA). Nanocomposites were prepared with blends of starch/PVA and nanofibrils of bamboo. Chemical pre-treatments and mechanical defibrillation were used to obtain the nanofibrils. The mixture containing 3% of starch and 4% of PVA in the proportion of 20/80 (starch/PVA) were chosen after preliminary testing. Atomic force microscopy (AFM) and transmission electronic microscopy (TEM) were used to characterize the bamboo nanofibrils. Microstructure of the nanocomposites was evaluated using scanning electron microscopy (SEM) and X-ray diffractrometry (XRD). Physical and mechanical properties were also evaluated. Results showed that pre-chemical treatments increased the content of the alpha-cellulose in bleached pulp by approximately 112% in relation to the native fiber. Increasing the number of passages through the defibrillator reduced the average diameter of the bamboo nanofibrils (from 82 ± 29 nm to 10 ± 6 nm). Addition of 6.5% nanofibrils improved the tensile strength and elongation at the break of the nanocomposite by 24 and 51%, respectively, but reduced the tensile modulus by 40% in relation to control (unreinforced) blend. Nanofibrils decreased the transparency of the nanocomposite films. The water vapor permeability and water solubility of the nanocomposite containing high contents of nanofibrils decreased up to 20% and 30%, respectively, in relation to the control blend.

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Section: Introductionmentioning

confidence: 98%

Starch/PVA-based nanocomposites reinforced with bamboo nanofibrils

Guimarães

Botaro

Novack

et al. 2015

Industrial Crops and Products

141

View full text Add to dashboard Cite

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“…The reports available in the literature to date are summarized in Table 2. 25,[48][49][50][51][52][53][54][55][56][57] Most studies showed CNCs to have no cytotoxic effects, as defined by ISO standard 10993-5, i.e., not to reduce cell viability by more than 30%. However, several studies found a dose dependency of CNC cytotoxicity.…”

Section: Cytotoxicitymentioning

confidence: 99%

Toxicity of Cellulose Nanocrystals: A Review

Roman

2015

Industrial Biotechnology

263

145

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Cellulose nanocrystals (CNCs) are a biobased nanomaterial attracting increasing interest for a range of potential applications. This article reviews the current literature on the pulmonary, oral, dermal, and cytotoxicity of CNCs. Current studies of the oral and dermal toxicity of CNCs have shown a lack of adverse health effects, whereas studies of the pulmonary and cytotoxicity have yielded discordant results. Additional studies are needed to support the general conclusion that CNCs are nontoxic on ingestion or contact with the skin and to determine whether CNCs have adverse health effects on inhalation or elicit inflammatory or oxidative stress responses at the cellular level. This review underscores the importance of careful sample characterization and exclusion of interfering factors, such as the presence of endotoxins or toxic chemical impurities, for a detailed understanding of the potential adverse health effects of CNCs by various exposure routes.

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“…Nanocellulose (NC) has also gained significant attention in pharmaceutical and biomedical applications recently, above all in wound healing (Napavichayanun et al 2016), tissue engineering (Gorgieva et al 2017;Markstedt et al 2015;Brown et al 2013), cell therapy (Lou et al 2014), gene (Ndong Ntoutoume et al 2017), drug delivery (Barbosa et al 2016;Dong et al 2014;Villanova et al 2011;Lin et al 2016), and diagnostics (Edwards et al 2016). Such a wide application spectrum is related mainly to their nanometer-sized features, large surface area, specific biomechanical characteristics, surface chemistry, ease of conjugation, high biocompatibility, and low (if any) cytotoxicity (Alexandrescu et al 2013) with tolerogenic potential to the immune system (Tomić et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Internalization of (bis)phosphonate-modified cellulose nanocrystals by human osteoblast cells

et al. 2017

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Covalent conjugation of (bis)phosphonate group-containing molecules, sodium Alendronate (Aln) and 3-AminoropylPhosphoric Acid (ApA), to Cellulose nanocrystals (CNCs) was performed via oxidation/Shiff-base reaction. Further fluorescent labelling with Rhodamine B Iso ThioCyanate (RBITC) was performed to follow CNCs interaction and potential internalization with/in human osteoblasts by confocal microscopy. Complementary analyses were applied to identify the conjugation (Atenuated Total Reflectance-Fourier Transform Infrared and UV-VIS spectroscopies), physico-chemical (Dynamic Light Scattering and Nanoparticle Tracking Analysis) and morphological (Transmission Electron Microscopy) features of native and ApA/Aln-modified CNCs in physiologically relevant environments (Phosphate Buffer Saline, Advanced Dulbecco's Modified Eagle Medium). While conjugation did not affect the CNCs' size, the RBITC-labelling promotes their aggregation. Faster (1 h vs. 2 h) uptake by osteoblasts of RBITCCNCoxAln, compared to RBITC-CNCoxApA, and no-internalization (in 24 h) of native RBITTC-CNC, indicate a higher affinity of Aln-modified CNCs to the cells, while all CNCs (in 0.25-0.06 wt%) promote the cell growth. Aln/Apa-modified CNCs shows high potential in drug-delivery for bone therapies, and theranostics.

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Pharmaceutical acrylic beads obtained by suspension polymerization containing cellulose nanowhiskers as excipient for drug delivery

Cited by 66 publications

References 49 publications

Starch/PVA-based nanocomposites reinforced with bamboo nanofibrils

Starch/PVA-based nanocomposites reinforced with bamboo nanofibrils

Toxicity of Cellulose Nanocrystals: A Review

Internalization of (bis)phosphonate-modified cellulose nanocrystals by human osteoblast cells

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