Pharma Since 1870

Daemmrich, Arthur; Bowden, Mary Ellen

doi:10.1021/cen-v083n025.p028

Cited by 27 publications

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“…Monoclonal antibodies dominate today's biopharmaceutical pipeline (1–3). Commercial manufacturing of a therapeutic antibody requires a process that delivers high yield and process reliability while producing an extremely pure product.…”

Section: Introductionmentioning

confidence: 99%

Basic Concepts in Q Membrane Chromatography for Large-Scale Antibody Production

2006

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The large-scale production of recombinant human monoclonal antibodies demands economical purification processes with high throughputs. In this article we briefly describe a common antibody process and evaluate the Q membrane adsorber for process-scale antibody production as an alternative to a Q-packed-bed column in a flow-through mode. The scientific concepts underlining Q membrane technology and its application are reviewed. The disadvantages and advantages of using Q membrane chromatography as a purification unit in large-scale production are discussed, including problems initially seen with the Q membrane scale-down model but solved with the invention of a new scale-down model. The new Q-membrane unit operation has a process capacity greater than 3,000 g/m(2) or 10.7 kg/L with a LRV over 5 for four model viruses. In this Review, a cost analysis illustrates that Q membrane chromatography is a viable alternative to Q column chromatography as a polishing step in a flow-through mode for process-scale antibody production.

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Section: Introductionmentioning

confidence: 99%

Basic Concepts in Q Membrane Chromatography for Large-Scale Antibody Production

2006

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Section: Introductionmentioning

confidence: 99%

“…Carbon-sulfur bonds are present in compounds of industrial interest, [1] in many natural products, [2] and in pharmaceuticals with therapeutic activity such as cimetidine (antiulcer), 6-mercaptopurine (leukemia), and thorazine (antipsychotic). [1] Specifically, thioethers play an important role in organosulfur chemistry. [3] The synthesis of thioethers historically predates that of ethers and, as the latter, generally involves nucleophilic substitution of conveniently functionalized substrates (i.e., Williamsons or Mitsunobus procedures).…”

Section: Introductionmentioning

confidence: 99%

Iron‐Catalysed Markovnikov Hydrothiolation of Styrenes

2012

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The bis(triflimide)ironA C H T U N G T R E N N U N G (III) salt catalyzes the hydrothiolation of styrenes in a Markovnikov fashion with good selectivities and high yields. After isolation, different benzylic thioethers are obtained. This ironA C H T U N G T R E N N U N G (III) catalyst is unique in terms of regioselectivity and represents a sustainable and economic alternative to those processes based on stoichiometric reagents. Scheme 1. Possible reaction pathways for the hydrothiolation of double bounds.

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“…Parazoanthine A was isolated as a major constituent of the Mediterranean sea anemone Parazoanthus axinellae, and its structure was elucidated through the use of NMR spectroscopic and mass spectrometric analyses. 66 In order to assign the absolute configuration of parazoanthine A as either S (7) or R (8), a comparison was made between the experimental and TDDFT-calculated CD spectra. Both of the enantiomers were subjected to energy minimization and subsequent CD spectral calculations using the B3LYP/6-31++G functional approach (Figure 4).…”

Section: Because Of Differences In Bond Angles and Interatomic Distanmentioning

confidence: 99%

“…Penicillin G (1) was first used on a large scale during World War II to treat soldiers wounded on battlefields to stave off infections. 7 Cephalosporin C (2) was first isolated from Cephalosporium acremonium by Brotzu in 1948, 8 and displayed activity against the cause of typhoid fever. The so-called 4 th generation cephalosporins are currently used to treat patients that are allergic to penicillins, and their broad spectrum of activity and excellent safety profiles make them one of the most widely prescribed class of antimicrobials in the world.…”

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confidence: 99%

Chemical investigations of secondary metabolites from selected fungi and from peanut seeds challenged by Aspergillus caelatus

Neff¹

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Many years of study have revealed that fungi are excellent sources of novel bioactive secondary metabolites. Some of these secondary metabolites possess therapeutic qualities that improve the quality of life for millions of people. Such metabolites include well known classes such as the penicillins, cephalosporins, and statins, yet many fungi remain underexplored as sources of biologically active metabolites. The research described in this thesis employs an ecology-based approach to targeting fungi for chemical investigation, and describes studies of fungi from two niche groups, fungicolous/mycoparasitic and endophytic fungi, as possible sources of new secondary metabolites with biological activities. In a parallel project, the structures of bioactive compounds isolated from peanut seeds that had been subjected to fungal attack were elucidated in the pursuit of compounds with beneficial bioactivities. Mycoparasitic fungi are those that colonize other fungi by parasitizing the host, often leading to damage to the host fungus. Fungicolous fungi are those that colonize other fungi, but have not been proven to be true mycoparasites. The damage often caused by colonization of host fungi indicates that mycoparasitic and fungicolous fungi can produce antifungal compounds. Chemical investigations of such fungi described in this thesis afforded 37 compounds representing various biosynthetic types, seven of which were new. Many of these compounds show antifungal, antimicrobial, and/or cytotoxic effects. Endophytic fungi live asymptomatically within plant tissues and in some cases may provide benefits to the host plant through the production of secondary metabolites. Chemical investigations of corn, wheat, and sorghum endophytes described in this thesis led to the isolation and characterization of 20 compounds, seven of which were identified as being new. Many of the fungal metabolites encountered in this work showed antifungal, antimicrobial, and/or cytotoxic effects. vi TABLE OF CONTENTS LIST OF TABLES .

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Pharma Since 1870

Cited by 27 publications

References 0 publications

Basic Concepts in Q Membrane Chromatography for Large-Scale Antibody Production

Basic Concepts in Q Membrane Chromatography for Large-Scale Antibody Production

Iron‐Catalysed Markovnikov Hydrothiolation of Styrenes

Chemical investigations of secondary metabolites from selected fungi and from peanut seeds challenged by Aspergillus caelatus

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