Pharkacokinetics and pharmacodynamics of furosemide after direct administration into the stomach or duodenum

Lee, Woo I.; Yoon, Woo H.; Shin, Wonjae; Song, In Soon; Lee, Myung G.

doi:10.1002/(sici)1099-081x(199712)18:9<753::aid-bdd63>3.0.co;2-k

Cited by 12 publications

(1 citation statement)

References 19 publications

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“…This drug, which has been widely used as a diuretic since the nineteen sixties, is one of the forty compounds having the highest risk with a predicted environmental concentration greater than 100 ng/L (Besse and Garric, 2008). Poorly metabolized and eliminated either unmodified or as glucuronide conjugate (Lee et al, 1997) (which releases furosemide after hydrolysis), this drug has been detected at concentration ranges between 61 and 200 ng/L in European rivers (Castiglioni et al, 2006;Khalaf et al, 2009). During the course of our preliminary study, three TPs of furosemide were identified: furfural 2, saluamine 3 (both resulting from the oxidation of the amino group) and a zwitterionic pyridinium 4 (resulting from the oxidation of the furan ring).…”

Section: Introductionmentioning

confidence: 91%

Anticipating the fate and impact of organic environmental contaminants: A new approach applied to the pharmaceutical furosemide

et al. 2014

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Section: Introductionmentioning

confidence: 91%

Anticipating the fate and impact of organic environmental contaminants: A new approach applied to the pharmaceutical furosemide

et al. 2014

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Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome p450 isozymes

2004

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The rats with protein-calorie malnutrition (PCM, 5% casein diet for a period of 4-week) were reported to exhibit 60 and 80% suppression in the hepatic microsomal cytochrome P450 (CYP) 1A2 and CYP2C11 levels, respectively, and 40-50% decreases in CYP2E1 and CYP3A1/2 levels compared to control (23% casein diet for a period of 4-week) based on Western blot analysis. In addition, Northern blot analysis showed that CYP1A2, CYP2E1, CYP2C11, and CYP3A1/2 mRNAs decreased in the state of PCM as well. Hence, pharmacokinetic changes of the drugs in rats with PCM [especially the area under the plasma concentration-time curve from time zero to time infinity (AUC) changes of metabolite(s)] reported from literatures were tried to explain in terms of CYP isozyme changes in the rats. Otherwise, the time-averaged nonrenal clearance (CL NR) of parent drug was compared. Pharmacokinetic changes of the drugs in other types of malnutritional state, such as kwashiorkor and marasmus, in both human and animal models were also compared. The drugs reviewed are as follows: diuretics, antibiotics, anticancer agents, antiepileptics, antiarrythmics, analgesics, xanthines, antimalarials, and miscellaneous.

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Effects of water deprivation on drug pharmacokinetics: Correlation between drug metabolism and hepatic CYP isozymes

Lee

2008

Arch. Pharm. Res.

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Male Sprague-Dawley rats deprived of water for 72 h (a rat model of dehydration) showed no change in protein expression of the hepatic microsomal cytochrome P450 (CYP) 1A2, 2B1/2, 2C11, or 3A1/2, but an increase in protein expression (3-fold) and mRNA level (2.6-fold) of CYP2E1. Glucose feeding instead of food normalized CYP2E1 protein expression during dehydration. Here, we review how dehydration can change the pharmacokinetics of drugs reported in the literature via changing CYP isozyme levels. We also discuss how dehydration changes the pharmacokinetics of drugs that are metabolized via renal DHP-I, or are mainly excreted in the urine and bile, and form conjugates.

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Pharkacokinetics and pharmacodynamics of furosemide after direct administration into the stomach or duodenum

Cited by 12 publications

References 19 publications

Anticipating the fate and impact of organic environmental contaminants: A new approach applied to the pharmaceutical furosemide

Anticipating the fate and impact of organic environmental contaminants: A new approach applied to the pharmaceutical furosemide

Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome p450 isozymes

Effects of water deprivation on drug pharmacokinetics: Correlation between drug metabolism and hepatic CYP isozymes

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