Phäochromozytomatose nach Adrenalektomie: Metastasierung oder Zellverschleppung?

Pheochromocytomatosis Treated With Peptide Receptor Radionuclide Therapy

“…Pheochromocytomatosis refers to pheochromocytoma tumorlets developed as a result of seeding of tumor cells around the surgical bed due to intraoperative tumor capsule rupture and tumor cell spillage. [1][2][3] As pheochromocytomatosis is relatively rare, optimal management is not clear. Surgical debulking, as in this case, is the first-line treatment and can often result in clinical remission.…”

“…Pheochromocytomatosis somewhat resembles metastatic pheochromocytoma in that they both are multifocal and incurable. 3 It is reasonable that targeted radionuclide therapy such as MIBG radiotherapy and PRRT intended for metastatic pheochromocytoma may also be used for pheochromocytomatosis recurrence after surgical debulking. [4][5][6][7][8] To our knowledge, this is the first case of pheochromocytomatosis treated with PRRT.…”

“…DOTATATE PET/CT 4 months after the last PRRT cycle (14 months after the second DOTATATE PET/CT) showed stable soft tissue nodularities in the abdominopelvic region (arrow and arrowhead), including the largest nodule along the splenic vessels (long arrow), and emergence of new tiny tumorlets (small arrow). Pheochromocytomatosis refers to pheochromocytoma tumorlets developed as a result of seeding of tumor cells around the surgical bed due to intraoperative tumor capsule rupture and tumor cell spillage 1–3 . As pheochromocytomatosis is relatively rare, optimal management is not clear.…”

“…Recurrence is bound to happen. [1][2][3] Management of recurrence is challenging. Pheochromocytomatosis somewhat resembles metastatic pheochromocytoma in that they both are multifocal and incurable.…”

“…Surgical debulking, as in this case, is the first-line treatment and can often result in clinical remission. Recurrence is bound to happen 1–3 . Management of recurrence is challenging.…”