Phantom limb perception interferes with motor imagery after unilateral upper-limb amputation

Lyu, Yuanyuan; Guo, Xiaoli; Bekrater-Bodmann, Robin; Flor, Herta; Tong, Shanbao

doi:10.1038/srep21100

Cited by 40 publications

(33 citation statements)

References 54 publications

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“…Similar observation was also reported with functional clinical outcome measures for conventional myoelectric hands users (and non-users) [26]. Moreover, prosthesis use has been shown to maintain phantom sensation vividness better than non-use [62], and prosthesis use can preserve mental rotation ability [63] which is shown to be in uenced by phantom sensation [64]. Lastly, neuroimaging studies have shown that use of myoelectric prosthesis could reduce cortical reorganization [65].…”

Section: Dimensionality Of Hand/wrist Muscle Contraction In Transradisupporting

confidence: 75%

Dimensionality of forearm muscle activation in transradial amputees

McClanahan¹,

Moench²,

Fu³

2020

Preprint

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Background Establishing a natural communication interface between the user and the terminal device is one of the central challenges of hand neuroprosthetics research. Surface electromyography (EMG) is the most common source of neural signals for interpreting a user’s intent in these interfaces. However, how the capacity of EMG generation is affected by various clinical parameters remains largely unknown. Methods In this retrospective study using an open source database, we examined the EMG activity of forearm muscles recorded from 11 transradially amputated subjects and 40 able-bodied subjects who performed a wide range of movements. By using non-negative matrix factorization, we extracted the synergistic EMG patterns for each subject to estimate the dimensionality of muscle control, under the framework of motor synergies. Results We found that amputees exhibited less than four synergies (with substantial variability related to the length of remaining limb and age), whereas able-bodied subjects commonly demonstrate five or more synergies. Conclusions The results of this study provide novel insight into the muscle synergy framework and the design of natural myoelectric control interfaces.

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Section: Dimensionality Of Hand/wrist Muscle Contraction In Transradisupporting

confidence: 75%

Dimensionality of forearm muscle activation in transradial amputees

McClanahan¹,

Moench²,

Fu³

2020

Preprint

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“…Just as implicated in SCI, central neuroplastic changes have also been suggested to drive the pathogenesis of NP following amputations. 41 , 42 Namely, the similar fMRI studies used to interrelate NP and SCI have also shown strong cortical and subcortical restructuring patterns in persons with NP after amputation, including structures involved in autonomic modulation. Even further, treating phantom pain has been found to correlate with the degree of somatosensory smudging.…”

Section: Discussionmentioning

confidence: 99%

Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction

Karri

Zhang

et al. 2018

JPR

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BackgroundRecent findings have implicated supraspinal origins from the pain neuromatrix– central autonomic network (PNM–CAN) in the generation of neuropathic pain (NP) after spinal cord injury (SCI). The aim of this study was to further investigate the theorized PNM–CAN mechanisms in persons with SCI by using a centrally directed pain intervention, provided by breathing-controlled electrical stimulation (BreEStim), to measure resultant autonomic changes measured by time and frequency domain heart rate variability (HRV) analysis.MethodsNull and active BreEStim interventions were administered to SCI+NP subjects (n=10) in a random order. HRV data and VAS pain scores were collected at resting pre-test and 30 minutes post-test time points. Resting HRV data were also collected from SCI–NP subjects (n=11).ResultsSCI+NP subjects demonstrated a lower baseline HRV and parasympathetic tone, via SD of the normal-to-normal intervals (SDNN) and low frequency (LF) parameters, compared with SCI–NP subjects. However, following active BreEStim, SCI+NP subjects exhibited an increase in HRV and parasympathetic tone, most notably via pairs of successive R–R beat lengths varying by greater than 50 ms (NN50) and proportion of NN50 for total number of beats (pNN50) parameters along with lower VAS scores. Additionally, the post-test SCI+NP group was found to have a statistically comparable autonomic profile to the SCI–NP group across all HRV variables, including SDNN and LF parameters.ConclusionThe analgesic effects of active BreEStim in SCI+NP subjects were associated with restoration of autonomic dysfunction in this population.

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“…Thus, amputees with PLP perform worse when they have to mentally rotate their limbs (e.g., [ 117 ]), and a negative association between performance in mental limb rotation and the frequency of PLP has been shown [ 118 ]. This suggests that phantom sensations in general [ 119 ] and PLP in particular are associated with impairments in the body schema, describing a flexible central representation of body posture that is needed for action. Since mental rotation of body parts involves motor imagery processes [ 120 ], and since the associated neural mechanisms are different in amputees with PLP compared to amputees without PLP [ 121 ], these results highlight the impaired mentalization of motor execution specifically for painful phantom limbs.…”

Section: Changes In Body Perception and Their Relationship To Plpmentioning

confidence: 99%

Psychological Factors Associated with Phantom Limb Pain: A Review of Recent Findings

Fuchs

Flor

Bekrater-Bodmann

2018

Pain Research and Management

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Phantom limb pain (PLP) is a common phenomenon occurring after the amputation of a limb and can be accompanied by serious suffering. Psychological factors have been shown to play an important role in other types of chronic pain, where they are pivotal in the acquisition and maintenance of pain symptoms. For PLP, however, the interaction between pain and psychological variables is less well documented. In this review, we summarize research on the role of emotional, motivational, cognitive, and perceptual factors in PLP. The reported findings indicate that emotional factors modulate PLP but might be less important compared to other types of chronic pain. Additional factors such as the amount of disability and adjustment to the amputation appear to also play a role. Bidirectional relationships between stress and PLP have been shown quite consistently, and the potential of stress and tension reduction in PLP treatment could be further exploited. Little is known about the role of cognitive variables such as attention or expectation. Catastrophizing seems to aggravate PLP and could be targeted in treatment. Body perception is altered in PLP and poses a potential target for novel mechanistic treatments. More research on psychological factors and their interactions in PLP is needed.

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Phantom limb perception interferes with motor imagery after unilateral upper-limb amputation

Cited by 40 publications

References 54 publications

Dimensionality of forearm muscle activation in transradial amputees

Dimensionality of forearm muscle activation in transradial amputees

Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction

Psychological Factors Associated with Phantom Limb Pain: A Review of Recent Findings

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