Phantom and animal imaging studies using PLS synchrotron X-rays

Kim, H.-J.; Hong, J.-O.; Lee, K.-H.; Jung, H.-J.; Kim, E.-K.; Je, J.H.; Kim, I.-W.; Hwu, Y.; Tsai, W.-L.; Seong, Jaehwan; Lee, S.-W.; Yoo, H.S.

doi:10.1109/nssmic.2000.949120

Cited by 2 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although it is assumed that the monochromatic SR beam offers high quality image acquisitions, especially when soft X-rays are used, due to the elimination of beam hardening artifacts related to use of polychromatic X-rays, the higher monochromaticity causes lower flux resulting in longer image acquisition times, of the order of a few seconds, for each projection [7], [16], and [17]. The PLS 5C1 imaging system with an unmonochromatized SR source demonstrated shorter image acquisition times, of the order of a few tens of a millisecond, permitting real-time imaging and high quality images, as compared with conventional imaging system, on a microscopic scale, for a variety of samples, across the fields of materials science, medicine and biology [1] and [2], [9], and [10].…”

Section: Discussionmentioning

confidence: 99%

“…We used the unmonochromatized SR X-ray beam for acquiring projection data in real time and demonstrated high quality images with micrometer resolution and phase contrast at object boundaries based on the refractive index rather than on the absorption versus monochromatic SR X-ray imaging systems of previous studies [1] and [2], [9] and [10]. This study presents the results of unmonochromatized SR CT images for cancerous human breast tissue as a soft tissue representative, and mouse vertebras as a hard tissue representative.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Computed microtomography (/spl mu/CT) with unmonochromatized synchrotron X-rays for cancerous human breast tissue and mouse vertebra

Jung

Kim

Hong

et al. 2002

IEEE Trans. Nucl. Sci.

View full text Add to dashboard Cite

The use of X-ray computed microtomography (CT) has increased in biomedical research and industrial applications. The inherited high quality of synchrotron radiation (SR) X-rays including high flux, collimation, and coherence, has been used recently to produce radiographic images with high spatial resolution and contrast. A simple and stable imaging system using an unmonochromatized SR source based on the principle of phase contrast X-ray imaging consists of a charge-coupled device (CCD) detector coupled with an optical lens system at the Pohang Light Source (PLS) 5C1 beamline. The spatial resolution of the imaging system was determined using the modulation transfer function (MTF), which was measured by step-by step calculations obtained from sharp edge images. Projection image data were obtained at 250 steps over 180 degrees of rotation with an acquisition time, depending on the imaged object materials, of 30 to 150 ms per projection image. The tomographic images were reconstructed using a simple filtered backprojection algorithm to reconstruct two-dimensional (2-D) images using projection data which may include characteristics of beam collimation and phase contrast. Although the use of a monochromatic X-ray beam has previously demonstrated to provide high resolution and enhanced contrast, our approach uses an unmonochromatized SR X-ray beam and shows similar image capability, without the needs for sophisticated X-ray optics, in an exposure time which is significantly less, by two orders of magnitude, than that for the monochromatic SR system. The current PLS 5C1 SR imaging system can produce projection images at a spatial resolution of 8.3 m over a field of view of about 5 mm at an exposure time of 30 ms per projection image for 1.5 optical magnification. This study presents the results of SR CT images of cancerous human breast tissue containing microcalcifications, mouse lumbar vertebra, and mouse coccygeal vertebra. The unmonochromatized SR CT imaging system provides an effective means of evaluating microstructures, not only in biomedical specimens but also in inorganic samples.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Computed microtomography (/spl mu/CT) with unmonochromatized synchrotron X-rays for cancerous human breast tissue and mouse vertebra

Jung

Kim

Hong

et al. 2002

IEEE Trans. Nucl. Sci.

View full text Add to dashboard Cite

show abstract

“…For example, it has recently been demonstrated that this approach can perform real time, high resolution coherence-based contrast imaging on live animals. 9 , 10 The purpose of this paper to establish the desired characteristics and comparative merits of this specific approach based on coherence-based contrast imaging, in order to evaluate its potential uses as a clinical diagnostic and pathological tool.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Unmonochromatized Synchrotron Radiation and Conventional X-rays in the Imaging of Mammographic Phantom and Human Breast Specimens: A Preliminary Result

Jung

Kim

et al. 2005

Yonsei Med J

View full text Add to dashboard Cite

A simple imaging setup based on the principle of coherence-based contrast X-ray imaging with unmonochromatized synchrotron radiation was used for studying mammographic phantom and human breast specimens. The use of unmonochromatized synchrotron radiation simplifies the instrumentation, decreases the cost and makes the procedure simpler and potentially more suitable for clinical applications. The imaging systems consisted of changeable silicon wafer attenuators, a tungsten slit system, a CdWO4 scintillator screen, a CCD (Charge Coupled Device) camera coupled to optical magnification lenses, and a personal computer. In preliminary studies, a spatial resolution test pattern and glass capillary filled with air bubbles were imaged to evaluate the resOolution characteristics and coherence-based contrast enhancement. Both the spatial resolution and image quality of the proposed system were compared with those of a conventional mammography system in order to establish the characteristic advantages of this approach. The images obtained with the proposed system showed a resolution of at least 25 µm on the test pattern with much better contrast, while the images of the capillary filled with air bubbles revealed coherence-based edge enhancement. This result shows that the coherence-based contrast imaging system, which emphasizes the refraction effect from the edge of materials of different refractive indexes, is applicable to imaging studies in fundamental medicine and biology, although further research works will be required before it can be used for clinical applications.

show abstract

Phantom and animal imaging studies using PLS synchrotron X-rays

Cited by 2 publications

References 10 publications

Computed microtomography (/spl mu/CT) with unmonochromatized synchrotron X-rays for cancerous human breast tissue and mouse vertebra

Computed microtomography (/spl mu/CT) with unmonochromatized synchrotron X-rays for cancerous human breast tissue and mouse vertebra

Comparison of Unmonochromatized Synchrotron Radiation and Conventional X-rays in the Imaging of Mammographic Phantom and Human Breast Specimens: A Preliminary Result

Contact Info

Product

Resources

About