Phagolysosomal activity of macrophages in Nile tilapia (Oreochromis niloticus) infected in vitro by Aeromonas hydrophila: Infection and immunotherapy

Fernandes, Dayanne Carla; Eto, Silas F.; Moraes, Alessandra Cristina de; Prado, E. J. R.; Medeiros, Andrea; Belo, Marco Antônio de Andrade; Samara, Samir Issa; Costa, Paulo Inácio da; Pizauro, João Martins

doi:10.1016/j.fsi.2018.12.074

Cited by 6 publications

(1 citation statement)

References 84 publications

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“…IgY-specific antibodies have been investigated as an alternative method to diagnose Aeromonas -diseased aquatic animals. IgY produced against Aeromonas hydrophila detected A. hydrophila in tissues and phagocytes in infected Nile tilapia ( 267 ), neutralized bacterial adhesins and toxins released by the bacteria, promoted agglutination, inhibited bacterial growth, and enhanced the phagocytic activity of infected Nile tilapia, blunt snout bream ( 268 , 269 ), and polyploid gibel carp ( 269 , 270 ). When added to rearing water, specific IgY eliminated the development of skin ulcers, as well as transmission of the infection between different fish ( 271 ).…”

Section: Treatment Of Bacterial Infectionsmentioning

confidence: 99%

Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases

et al. 2021

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Antiviral, antibacterial, and antiparasitic drugs and vaccines are essential to maintaining the health of humans and animals. Yet, their production can be slow and expensive, and efficacy lost once pathogens mount resistance. Chicken immunoglobulin Y (IgY) is a highly conserved homolog of human immunoglobulin G (IgG) that has shown benefits and a favorable safety profile, primarily in animal models of human infectious diseases. IgY is fast-acting, easy to produce, and low cost. IgY antibodies can readily be generated in large quantities with minimal environmental harm or infrastructure investment by using egg-laying hens. We summarize a variety of IgY uses, focusing on their potential for the detection, prevention, and treatment of human and animal infections.

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