Phagocytizing Capacity of the Neutrophil Leucocyte in Primary “Acquired” Hypogammaglobulinaemia

Forssman, Olof

doi:10.1111/apm.1965.65.3.366

Cited by 2 publications

(1 citation statement)

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“…It has been reported that patients with Swiss type agammaglobulinemia have decreased phagocytic function (5,6), but some of these patients are also complement deficient (7,8). On the other hand, there have been no reports of systematic studies of phagocytic function in other types of hypogammaglobulinemia beyond several case reports in which leukocyte function appeared to be normal (9,10). In the present investiReceived for publication 12 January 1970 and in revised form 13 April 1970. gations, three adult patients with acquired hypogammaglobulinemia were studied to determine the phagocytic, bactericidal, and metabolic properties of their peripheral leukocytes, with particular attention to the influence of homologous or normal serum upon these functions.…”

Section: Introductionmentioning

confidence: 99%

Leukocytic function in hypogammaglobulinemia

Mickenberg¹,

Root²,

Wolff³

1970

J. Clin. Invest.

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A B S T R A C T The phagocytic, bactericidal, and metabolic capabilities of circulating blood leukocytes from three adults (two males, one female) with hypogammaglobulinemia and recurrent pneumonia, chronic sinusitis, and intestinal giardiasis were studied. These functions were found to be normal when leukocytes from the patients were incubated in media containing normal human serum. Phagocytosis of Staphylococcus albus and polystyrene balls by both patient and normal leukocytes was diminished when the cells were incubated in hypogammaglobulinemic plasma. A similar defect in opsonization by patient plasma was also noted for pneumococci, Escherichia coli and variably with Staphylococcus aureus. Both patient and normal sera had equivalent levels of heat-labile S. albus opsonins; normal serum, however, contained heat-stable S. albus-specific absorbable opsonins in significantly greater quantities to account for its superior opsonic capacity. The addition of commercial gamma globulin or purified IgG to hypogammaglobulinemic sera restored full S. albus opsonic activity. The relevancy of these observations to the impaired host defenses in these patients will be discussed.

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Section: Introductionmentioning

confidence: 99%