2011
DOI: 10.1016/j.ajpath.2010.12.051
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Phagocytic Clearance in Neurodegeneration

Abstract: The cellular and molecular mechanisms of phagocytic clearance of apoptotic cells and debris have been intensely studied in invertebrate model organisms and in the mammalian immune system. This evolutionarily conserved process serves multiple purposes. Uncleared debris from dying cells or aggregated proteins can be toxic and may trigger exaggerated inflammatory responses. Even though apoptotic cell death and debris accumulation are key features of neurodegenerative diseases, relatively little attention has been… Show more

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Cited by 96 publications
(93 citation statements)
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“…Supporting a phagocytic role for reactive astrocytes in AD, it has been suggested that they could mediate Aβ clearance (Osborn et al, 2016) and limit amyloid deposits (Xiao et al, 2014) since these glial cells express many potential phagocytic receptors that bind Aβ (Jones, Minogue, Connor, & Lynch, 2013; Sokolowski & Mandell, 2011). Moreover, astrocytes in culture are highly phagocytic cells (Roldán, Gogg, Ferrini, Schillaci, & De Nicola, 1997; Tansey & Cammer, 1998), and can phagocytose Aβ (Wyss‐Coray et al, 2003) and apoptotic cells (Chang, Barbaro, & Pieper, 2000) and effectively engulf whole dead cells following neural scratch injury in vitro (Lööv, Hillered, Ebendal, & Erlandsson, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…Supporting a phagocytic role for reactive astrocytes in AD, it has been suggested that they could mediate Aβ clearance (Osborn et al, 2016) and limit amyloid deposits (Xiao et al, 2014) since these glial cells express many potential phagocytic receptors that bind Aβ (Jones, Minogue, Connor, & Lynch, 2013; Sokolowski & Mandell, 2011). Moreover, astrocytes in culture are highly phagocytic cells (Roldán, Gogg, Ferrini, Schillaci, & De Nicola, 1997; Tansey & Cammer, 1998), and can phagocytose Aβ (Wyss‐Coray et al, 2003) and apoptotic cells (Chang, Barbaro, & Pieper, 2000) and effectively engulf whole dead cells following neural scratch injury in vitro (Lööv, Hillered, Ebendal, & Erlandsson, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…Neuroinflammatory proteins (cytokines and chemokines) are hypothesized to have an influential role in determining microglia phagocytosis phenotypes that can contribute to either continued health or chronic disease (Amantea, 2016;Sokolowski and Mandell, 2011). We observed that inflammatory proteins are present and detectable in the healthy cortex, however, the concentration of these proteins were similar among sex groups in adult mice.…”
Section: Discussionmentioning
confidence: 38%
“…91 A variety of clearance pathways of Aβ in AD have been actively studied. 92 Microglia and astrocytes have been reported to be able to phagocytose Aβ and immunization with Aβ was shown to promote clearance, 93 which are currently considered the most effective therapeutic targets against AD. 94 Clusterin has also been reported to bind to Aβ and enhance Aβ clearance as a chaperone.…”
Section: Resultsmentioning
confidence: 99%
“…94 Clusterin has also been reported to bind to Aβ and enhance Aβ clearance as a chaperone. 93 Passive immunization against prion has shown to decrease CNS pathology. 95 Immunization strategies against tau and mutant SOD-1 could also be used to treat AD and ALS, respectively.…”
Section: Resultsmentioning
confidence: 99%