Phage‐mediated Biocontrol Against Plant Pathogenic Bacteria

Clavijo-Coppens, Fernando; Torres‐Barceló, Clara; Ansaldi, Mireille; TAVEAU, Nicolas

doi:10.1002/9781394188277.ch8

Cited by 3 publications

(1 citation statement)

References 134 publications

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“…For therapeutic purposes, strictly virulent phages are preferred in order to prevent lysogeny-related issues. Besides the life cycle, phage genomic information is also required to identify undesirable phage-coded genes, such as integrases, transposases or toxins [16]. For staphylococcal infections, Kayvirus are the more represented genus of phages targeting staphylococcal bacteria and represent one of the best control agents.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of New Bacteriophages against Staphylococcal Clinical Isolates from Diabetic Foot Ulcers

Plumet,

Morsli,

Ahmad-Mansour

et al. 2023

Viruses

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Staphylococcus sp. is the most common bacterial genus in infections related to diabetic foot ulcers (DFUs). The emergence of multidrug-resistant bacteria places a serious burden on public health systems. Phage therapy is an alternative treatment to antibiotics, overcoming the issue of antibiotic resistance. In this study, six phages (SAVM01 to SAVM06) were isolated from effluents and were used against a panel of staphylococcal clinical samples isolated from DFUs. A genomic analysis revealed that the phages belonged to the Herelleviridae family, with sequences similar to those of the Kayvirus genus. No lysogeny-associated genes, known virulence or drug resistance genes were identified in the phage genomes. The phages displayed a strong lytic and antibiofilm activity against DFU clinical isolates, as well as against opportunistic pathogenic coagulase-negative staphylococci. The results presented here suggest that these phages could be effective biocontrol agents against staphylococcal clinical isolates from DFUs.

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Section: Introductionmentioning

confidence: 99%