Phaeohyphomycotic cyst of the skin caused by Exophiala jeanselmei

Zackheim, Herschel S.; Halde, Carlyn; Goodman, Richard S; Marchasin, Sidney; Buncke, Harry J.

doi:10.1016/s0190-9622(85)80019-0

Cited by 21 publications

(6 citation statements)

References 11 publications

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“…They have also been referred to as sclerotic bodies, sclerotia, medlar bodies, and copper pennies. The pathology of primary cutaneous phaeoliyphomycosis is variable compared to the more constant picture seen in chromoblastomycosis (5)(6)(7)(8)(9)(10)(11). The latter is characterized by epidermal hyperplasia, epidermal and dermal microabscesses, and granulomas.…”

Section: Discussionmentioning

confidence: 99%

“…The yeast-like cells may resemble the murilorm cells of chromoblastomyco- sis, however, the former are lighter and can therefore be overlooked on H&E. Also, they have thinner walls, show septation in only one plane, and have a chain morphology. Of the 5 patterns of infection described, the most commonly reported is the phaeomycotic cyst, hence it is usually easily recognized (1,(8)(9)(10)12). Nine cases from Malawi and 25 cases from the Armed Forees Institute of Pathology (AFIP) showed this type of pattern (8,9).…”

Section: Discussionmentioning

confidence: 99%

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Primary cutaneous phaeohyphomycosis: report of seven cases

et al. 1993

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We report seven cases of primary cutaneous phaeohyphomycosis. There were five males and two females, ranging in age from 42-65 years (mean 57.7 years). Two patients were otherwise healthy, but five were immunocompromised. One patient had rheumatoid arthritis and was on oral prednisone; two were renal transplant recipients, one was a heart transplant recipient, and the fifth had dermatomyositis. No history of trauma was elicited from any of the patients, but in two cases, foreign material was seen in the tissue sections. All lesions were on the extremities. In two cases, tissues were cultured, and these grew Exophiala jeanselmei. The others were not cultured because fungal infection was not clinically suspected. No systemic disease developed in any of the cases, and all were cured by the simple, complete excision of the lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary cutaneous phaeohyphomycosis: report of seven cases

et al. 1993

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“…In the series of Ziefer and Connor (2), 9 of 25 patients were immunocompromised by various conditions including immunosuppressive therapy, infection with chronic debilitating disease, and malnutrition. Phaeohyphomycosis and hyalohyphomycosis have been reported in renal transplant patients (5), leukemia patients (7), in individuals receiving long-term prednisone therapy (11), and in patients with acquired immunodeficiency syndrome (AIDS) (8). In a case report (8), phaeophyphomycosis presented in an AIDS patient as multiple 1-to 3-mm pigmented papules on the scrotum that resembled seborrheic keratoses.…”

Section: Discussionmentioning

confidence: 99%

Hyalohyphomycosis masquerading as squamous cell carcinoma

Griffin

McFarland

1991

J Cutan Pathol

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A case of primary cutaneous hyalohyphomycosis in a healthy individual is presented. The initial clinical impression was keratoacanthoma or squamous cell carcinoma. Upon excision, the lesion proved to be an example of cutaneous hyalohyphomycosis due to an unidentified, non-pigmented fungal organism. The lesion was completely excised, and the patient was treated with saturated solution of potassium iodide. To date, there has been no evidence of recurrence. The clinical, histologic and mycologic aspects of hyalophyphomycosis are discussed.

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“…The failure of phaeohyphomycosis infections to clear with numerous antifungal medications in addition to cryotherapy has been reported, 126 as has a phaeohyphomycotic cyst failing to respond to local heat treatment. 127 Thermotherapy. Systemic antifungals, while the mainstay of therapy, carry associated toxicities or may be otherwise poorly tolerated by patients, particularly in patients already receiving immunosuppressive agents.…”

Section: Opportunistic Mycosesmentioning

confidence: 99%