Phaeohyphomycosis due to<i>Cladosporium cladosporioides</i>

Vieira, M. R.; Milheiro, A.; Pacheco, F. Assis

doi:10.1080/mmy.39.1.135.137

Cited by 48 publications

(11 citation statements)

References 5 publications

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“…Case reports have shown a favorable outcome using azole-based therapies. ITC has shown efficacy in the treatment of superficial infections caused by C. cladosporioides, C. sphaerospermum, and C. oxysporum (8,14,37,(41)(42)(43)(44), while VRC was effective against C. macrocarpum in a brain abscess (17). This agrees with our in vitro data, which demonstrated that the azoles, particularly ITC and PSC, have good activity against Cladosporium species, although VRC displayed variable activity.…”

Section: Discussionsupporting

confidence: 82%

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Cladosporium Species Recovered from Clinical Samples in the United States

et al. 2015

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bCladosporium species are ubiquitous, saprobic, dematiaceous fungi, only infrequently associated with human and animal opportunistic infections. We have studied a large set of Cladosporium isolates recovered from clinical samples in the United States to ascertain the predominant species there in light of recent taxonomic changes in this genus and to determine whether some could possibly be rare potential pathogens. A total of 92 isolates were identified using phenotypic and molecular methods, which included sequence analysis of the internal transcribed spacer (ITS) region and a fragment of the large subunit (LSU) of the nuclear ribosomal DNA (rDNA), as well as fragments of the translation elongation factor 1 alpha (EF-1␣) and actin (Act) genes. The most frequent species was Cladosporium halotolerans (14.8%), followed by C. tenuissimum (10.2%), C. subuliforme (5.7%), and C. pseudocladosporioides (4.5%). However, 39.8% of the isolates did not correspond to any known species and were deemed to comprise at least 17 new lineages for Cladosporium. The most frequent anatomic site of isolation was the respiratory tract (54.5%), followed by superficial (28.4%) and deep tissues and fluids (14.7%). Species of the two recently described cladosporiumlike genera Toxicocladosporium and Penidiella are reported for the first time from clinical samples. In vitro susceptibility testing of 92 isolates against nine antifungal drugs showed a variety of results but high activity overall for the azoles, echinocandins, and terbinafine.

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Section: Discussionsupporting

confidence: 82%

“…Most data are from a few reported clinical cases (7,13,15,41). Our study provides the first in vitro data for a large set of clinical isolates, including several species obtained from diverse anatomical sites and not previously reported from clinical samples.…”

Section: Discussionmentioning

confidence: 93%

Cladosporium Species Recovered from Clinical Samples in the United States

et al. 2015

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“…Cladosporium cladosporioides , which causes reproductive disorders in cows [ 20 ] and phaeohyphomycosis in humans [ 21 ] and giant pandas [ 12 ], was also isolated from the vagina and foreskin samples.…”

Section: Discussionmentioning

confidence: 99%

Isolation and identification of culturable fungi from the genitals and semen of healthy giant pandas (Ailuropoda melanoleuca)

Hou

et al. 2017

BMC Vet Res

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BackgroundIn order to better understand the possible role of fungi in giant panda reproduction and overall health, it is important to provide a baseline for the normal fungal composition in the reproductive system. Using morphology and internal transcribed spacer (ITS) sequence analysis, we systematically isolated and identified fungal species from the vagina, foreskin, and semen of 21 (11 males and 10 females) healthy giant pandas to understand the normal fungal flora of the genital tracts.ResultsA total of 76 fungal strains were obtained, representing 42 genera and 60 species. Among them 47 fungal strains were obtained from vaginal samples, 24 from foreskins, and 5 from semen samples. Several fungal strains were isolated from more than one sample. More fungal species were isolated from females from males. The predominant genera were Aspergillus, Trichosporon, and Penicillium, followed by Candida, Cladosporium, Sordariomycetes, and Diaporthe. The average number of strains in the female vagina was significantly higher than in the foreskin and semen of male.ConclusionsA total of 60 fungal species (belonging to 42 genera) were identified in the giant panda’s genital tract. Some of the species were commonly shared in both males and females. These findings provide novel information on the fungal community in the reproductive tracts of giant pandas.

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“…Verrucous plaque in subcutaneous phaeohyphomycosis can also be caused by Cladosporium sphaerospermum (Qiu-Xia et al, 2008). However, C. cladosporioides can cause skin infections in healthy immunocompetent individuals (Vieira et al, 2001) and scalp infections (Sosa et al, 2012). Jayasinghe et al (2017) reported a rare case of unilateral cervical lymphadenopathy due to C. oxysporum in a young adult without any systemic infection (Jayasinghe et al, 2017).…”

Section: Genus: Cladosporiummentioning

confidence: 99%