Phaeochromocytoma of the Ovary

Fawcett, F. J.; Kimbell, Norman

doi:10.1111/j.1471-0528.1971.tb00301.x

Cited by 35 publications

(6 citation statements)

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“…Hayashi et al have reported a case of small cell carcinoma of the vagina in a 91-year-old woman (8). Ovarian and uterine paragangliomas are equally rare as those arising in the vagina (9)(10)(11)(12)(13)(14). The current case is the fourth paraganglioma to be described in the vagina (2)(3)(4).…”

Section: Fig 2 Amentioning

confidence: 99%

Paraganglioma of the Vagina: Report of a Case, Including Immunohistochemical and Ultrastructural Findings

Hassan

Bennet

Bhalla

et al. 2003

International Journal of Gynecological Pathology

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Paragangliomas are uncommon neoplasms of the female genital tract, with fewer than 15 reported cases arising from the uterus, ovary, vagina, and cervix. Three of these tumors presented in the vagina. This report describes the authors' experience with a paraganglioma of the vagina in a 24-year-old woman that presented as an asymptomatic mass. The histologic features in the initial biopsy proved again that the paraganglioma may be confused with other vascular neoplasms. The clinical course after the biopsy implied that this neoplasm had been awakened from its functionless dormancy.

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Section: Fig 2 Amentioning

confidence: 99%

Paraganglioma of the Vagina: Report of a Case, Including Immunohistochemical and Ultrastructural Findings

Hassan

Bennet

Bhalla

et al. 2003

International Journal of Gynecological Pathology

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“…One case has been excluded as describing a case of peritoneal carcinomatosis from extra‐adrenal paraganglioma in a male patient . Therefore, the studies included in this review are eight published in peer‐reviewed journals . Table shows the clinical characteristics of published cases of OP.…”

Section: Resultsmentioning

confidence: 99%

Peritoneal carcinomatosis from ovarian paraganglioma: Report of a rare case and systematic review of the literature

Bizzarri

Cian

Domenico

et al. 2018

J of Obstet and Gynaecol

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Paraganglioma is one of the rarest neoplasms involving the ovary, with only 10 previous reports. We present a case of peritoneal carcinomatosis from primary ovarian paraganglioma and a systematic review of the literature. Clinical information was retrieved from medical records, and a systematic review of the literature was performed according to meta-analysis of observational studies in epidemiology guidelines. A 33-year-old woman presented with a 12-month history of hypertension and weight loss. She was diagnosed with ovarian paraganglioma and was treated with extensive debulking surgery to no residual disease after three cycles of neoadjuvant chemotherapy. She recurred after 6 months and was started on somatostatin-analogue. Following further disease progression with bone metastasis (treated with palliative radiotherapy), a trial with Sunitinib was started. The patient died 30 months after initial diagnosis. Of the cases reported to date, only one had peritoneal metastasis at presentation but none of them had such an ominous prognosis. Ovarian paraganglioma is an extremely rare condition. We report the first case of primary malignant ovarian paraganglioma with an exceptionally aggressive behavior. Clinicopathological correlation with immunohistochemistry is essential to avoid misdiagnosis. A standard treatment is not recommended yet but cytoreductive surgery seems to be a favorable approach to prolong survival.

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“…Although they have been described in the vagina, uterus, and vulva, 1-3 their exact incidence is uncertain. In the 5 reported ovarian cases, 4,5,8 the age of presentation was variable, ranging from the young 4 to postmenopausal patients. 6 All reported cases were of sporadic type and in only one instance bilateral.…”

Section: Discussionmentioning

confidence: 99%

“…3 In the ovary, only 5 cases have been reported. 4-6 These tumors are often associated with clinical hypertension and usually follow a benign course. Immunohistochemically, they have a well-established phenotype.…”

Section: Introductionmentioning

confidence: 99%

Ovarian Paraganglioma

et al. 2014

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A rare case of ovarian paraganglioma was incidentally found as a 1.2-cm intraovarian mass in a 68-year-old hypertensive female operated for an endometrial carcinoma. Histologically, it was arranged in characteristic Zellballen composed of polygonal clear cells with a granular cytoplasm that expressed diffusely CAM5.2 cytokeratin, chromogranin, neuron-specific enolase, synaptophysin, and CD56, while S-100 protein was only present in sustentacular cells. We analyzed differential diagnoses with other rare ovarian tumors such as Sertoli cell tumor, with which it may share an immunophenotype expressing cytokeratins, S-100, and other neural markers, and extra-axial ependymoma, which invariably expresses diffusely GFAP, that may be positive only in the sustentacular cells of paraganglioma. However, on simple hematoxylin-eosin inspection, ovarian paraganglioma displays characteristic Zellballen clusters and cells with a granular cytoplasm but lacks the distinctive Sertoli cell tubules and the characteristic rosettes and fibrillary cytoplasm of ependymoma. Pathologists should be aware of the unusual locations of paraganglioma.

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Phaeochromocytoma of the Ovary

Abstract: AND SummaryA case of phaeochromocytoma of the ovary simulating pre-eclamptic toxaemia of pregnancy in a 15-year-old girl is reported.

Cited by 35 publications

References 1 publication

Paraganglioma of the Vagina: Report of a Case, Including Immunohistochemical and Ultrastructural Findings

Paraganglioma of the Vagina: Report of a Case, Including Immunohistochemical and Ultrastructural Findings

Peritoneal carcinomatosis from ovarian paraganglioma: Report of a rare case and systematic review of the literature

Ovarian Paraganglioma

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