PHA-T cells in systemic lupus erythematosus and in rheumatoid arthritis: Abnormalities in HLA Class II antigen induction and in autologous mixed lymphocyte reactions

Indiveri, F; Scudeletti, Marco; Pierri, Ivana; Traverso, A. Buzzati; Cerri, Carla; Ferrone, Soldano

doi:10.1016/0008-8749(86)90389-8

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…The biological and clinical significance as well as the mechanism(s) underlying these abnormalities are not known. They are likely to represent nonspecific expression of defects of the immune system, since they have been found in a variety of conditions associated with functional disorders of the immune system [6,7,9,11,21,22].…”

Section: Discussionmentioning

confidence: 99%

Abnormalities of T cells isolated from mediastinal lymph nodes and peripheral blood of patients with lung carcinoma: deficit in PHA-induced expression of HLA class II antigens and in autologous mixed lymphocyte reactions

Indiveri¹,

Pierri

Rogna

et al. 1986

Cancer Immunol Immunother

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A reduced percentage of T cells isolated from mediastinal lymph nodes and peripheral blood of patients with lung carcinoma acquired HLA Class II antigens following in vitro stimulation with PHA. Furthermore T cells were functionally abnormal in autologous and allogeneic mixed lymphocyte reactions (MLR). The immunoregulatory properties of HLA Class II antigens and autologous MLRs suggest that these abnormalities may affect the interaction of the host's immune system with tumor cells.

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Section: Discussionmentioning

confidence: 99%

Abnormalities of T cells isolated from mediastinal lymph nodes and peripheral blood of patients with lung carcinoma: deficit in PHA-induced expression of HLA class II antigens and in autologous mixed lymphocyte reactions

Indiveri¹,

Pierri

Rogna

et al. 1986

Cancer Immunol Immunother

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Defective mitogen-induced cellular cytotoxicity in untreated patients with active rheumatoid arthritis

et al. 1994

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Peripheral blood mitogen-induced cellular cytotoxicity (MICC) was studied in 13 untreated patients with active rheumatoid arthritis (RA; group A) and in 5 RA patients with inactive disease (group B), using phytohemagglutinin (PHA) as stimulating agent and K562 cells as target cells in the chromium-51 release assay. MICC was found to be significantly reduced in the patients of group A compared with normal subjects (P < 0.01) and the patients of group B (P < 0.05). No differences were noted in MICC between group B patients and normal subjects. A statistically significant negative correlation was found between values of patients' MICC and serum C-reactive protein levels (r = -0.685, P < 0.01). Furthermore, patients' MICC correlated well with patients' peripheral blood natural killer cell activity (P < 0.02), as well as with the absolute number of circulating CD8+ cells. No correlation was found between MICC and duration of disease, erythrocyte sedimentation rate, serum alpha 2-globulins, or the titre of serum rheumatoid factor in the patients studied. We concluded that defective MICC in untreated patients with active RA is probably due to the diminution of the number of CD8+ cells, although a qualitative defect of these cells cannot be excluded.

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Impairment of autologous mixed lymphocyte reaction in the spleen and peripheral blood lymphocytes of patients with idiopathic portal hypertension

Yamaue¹,

Tanimura²,

Itō³

et al. 1990

Gastroenterol Jpn

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The etiology of idiopathic portal hypertension (IPH) is unknown, although many studies have suggested that it might be an autoimmune disease. The autologous mixed lymphocyte reaction (AMLR) involves the proliferation of T lymphocytes when co-cultured with autologous non-T cells and may reflect immune control mechanisms in vivo. The AMLRs in the spleen and peripheral blood of three patients with IPH were measured and it was shown that the AMLRs both in the spleen and peripheral blood were significantly suppressed compared to those of normal healthy subjects. By allogeneic MLR, there was a tendency that the disturbance of non-T cells was more intensive than that of T cells. The AMLR of peripheral blood did not improve by splenectomy. Thus, the depressed cause of AMLR in patients with IPH was suggested mainly to disturbance of the antigen-presenting ability of non-T cells, and it was suggested that not only the spleen cells, but systemic immune disturbance caused the impairment of AMLR in IPH.

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PHA-T cells in systemic lupus erythematosus and in rheumatoid arthritis: Abnormalities in HLA Class II antigen induction and in autologous mixed lymphocyte reactions

Cited by 4 publications

References 16 publications

Abnormalities of T cells isolated from mediastinal lymph nodes and peripheral blood of patients with lung carcinoma: deficit in PHA-induced expression of HLA class II antigens and in autologous mixed lymphocyte reactions

Abnormalities of T cells isolated from mediastinal lymph nodes and peripheral blood of patients with lung carcinoma: deficit in PHA-induced expression of HLA class II antigens and in autologous mixed lymphocyte reactions

Defective mitogen-induced cellular cytotoxicity in untreated patients with active rheumatoid arthritis

Impairment of autologous mixed lymphocyte reaction in the spleen and peripheral blood lymphocytes of patients with idiopathic portal hypertension

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