pH Values and Blood-Gas Tensions in the Normal Piglet during the First 48 Hours of Life

Randall, G. C. B.

doi:10.1159/000240447

Cited by 23 publications

(15 citation statements)

References 6 publications

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“…2). Yet, the average acid-base balance values in RBS from the UA remained fairly stable throughout the surgical procedure (Table 2) and are well in range with values reported in newborn piglets in literature [3,15,[23][24][25][26]. Only a gradual, small increase of lactate values in RBS from the UA was observed.…”

Section: Discussionsupporting

confidence: 81%

Umbilical cord clamping in term piglets: A useful model to study perinatal asphyxia?

et al. 2008

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Perinatal asphyxia results in tissue and cellular changes during the reperfusion period and clinical signs like perinatal mortality and decreased vitality at birth in newborn piglets. This study aimed to develop and validate a model of birth asphyxia, mimicking the evolvement of birth asphyxia in natural farrowings by conducting umbilical cord clamping (UCC) in term piglets during caesarean sections under general anaesthesia. In total 23 piglets were subjected to 5-8 min of UCC and 24 piglets served as controls. Acid-base balance values and heart rates measured before UCC remained fairly constant throughout the surgical procedure, indicating nearly identical starting conditions of piglets within and between litters. UCC resulted in a significant, mild, mixed respiratory-metabolic acidosis (pH 7.22, pCO 2 9.8 kPa, BE ecf 2 mmol/L, lactate 6.5 mmol/L; controls: pH 7.31, pCO 2 8.5 kPa, BE ecf 5 mmol/L, lactate 4 mmol/L) at 10 min after birth (defined as simultaneous cutting of the umbilical cord and removal of a plastic bag that had been placed over the head to avoid air intake). Heart rates were significantly decreased during UCC (range: 83-107 beats/min versus 128-134 beats/ min in controls). Rectal temperatures and changes in body weight until 72 h of life were not affected by UCC. Interestingly, four control and seven clamped piglets did not survive as no independent respiration could be attained. Birth weights and duration of UCC of these piglets did not differ significantly from those in surviving control and clamped piglets. In conclusion the mixed respiratory-metabolic acidosis arising in the surviving clamped piglets is not as severe as can be expected in highly asphyxiated, vaginally delivered newborn piglets. Repeatability of the model is compromised by considerable variation in the individual response to UCC. #

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Section: Discussionsupporting

confidence: 81%

Umbilical cord clamping in term piglets: A useful model to study perinatal asphyxia?

et al. 2008

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“…Although only 23.5 h were allowed for recov ery from anaesthesia, we have found pre viously that 4 h after administration of methoxyflurane, blood gases, body temperature and heart rate have all returned to normal [ 12], In this study blood gas values at both 24 and 48 h after birth were within the normal range for neonatal piglets [19], and were not significantly different (p > 0.05).…”

Section: Discussionsupporting

confidence: 40%

Cerebral Blood Flow and Metabolism in Fasting Neonatal Piglets

Flecknell

Wootton

1989

Neonatology

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Cerebral blood flow and cerebral metabolism were studied in 8 fasting neonatal piglets. Cerebral blood flow was not significantly different (p > 0.1) at 24 h (75.0 ± 30.7 ml/min/100 g) and 48 h (74.2 ± 32.3 ml/min/100 g) of age. Blood glucose concentration was lower in 48-hour-old fasted piglets (1.27 ± 0.60 mmol/l) in comparison with 24-hour-old fasted animals (2.90 ± 0.52 mmol/l), and cerebral glucose utilisation rate was also reduced in the 48-hour-old piglets (17.6 ± 6.0 μmol/min/100 g at 48 h, 34.2 ± 12.2 μmol/min/100 g at 24 h). Blood lactate concentration and cerebral lactate utilisation rate were not significantly different at 24 and 48 h of age. Brain lactate utilisation accounted for approximately 10% of cerebral oxygen utilisation at 48 h in fasted piglets. Cerebral glucose and lactate utilisation at 48 h accounted for approximately 66% of cerebral oxygen uptake, indicating that other substrates make a major contribution to cerebral metabolic requirements in fasting neonatal piglets.

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“…They were lightly anesthetized with halothane (0.25-0.75%) in a 1:4 mixture of N20 and 0 2. All animals were venti lated to maintain arterial PCO, and pH at normal levels for piglets (14). Rectal temperature was main tained (by hydrothermic pad) between 37 and 39 °C, depending upon the age of the animal (6).…”

Section: Methodsmentioning

confidence: 99%

Integrated Cardiovascular Responses to Combined Somatic and Visceral Afferent Stimulation in Newborn Piglets

Gootman¹,

Gootman²,

Crane³

et al. 1979

Neonatology

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Mean aortic pressure, arterial flow and heart rate responses to interactions of afferent stimulation of the sciatic nerve (SNS) and carotid sinus stimulation by infusion (CSI) or inhibition by bilateral common carotid occlusion (BCCO) were studied in 25 newborn piglets under halothane-N₂O anesthesia. Combined stimulation of the somatic and visceral afferents produced no heart rate changes. Combinations of pressor stimuli (BCCO and high frequency SNS) showed facilitation; femoral and renal resistances increased. However, combinations of depressor stimuli (CSI and low frequency SNS) showed occlusion. In combinations of pressor with depressor stimuli, the pressor pattern of responses dominated. Thus, dissimilar types of excitatory afferent inputs are capable of evoking facilitation in the neonatal cardiovascular regulatory system.

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pH Values and Blood-Gas Tensions in the Normal Piglet during the First 48 Hours of Life

Cited by 23 publications

References 6 publications

Umbilical cord clamping in term piglets: A useful model to study perinatal asphyxia?

Umbilical cord clamping in term piglets: A useful model to study perinatal asphyxia?

Cerebral Blood Flow and Metabolism in Fasting Neonatal Piglets

Integrated Cardiovascular Responses to Combined Somatic and Visceral Afferent Stimulation in Newborn Piglets

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