pH/temperature sensitive chitosan-g-(PA-PEG) aqueous solutions as new thermogelling systems

Jang, Ji Hye; Choi, Yoon Mi; Choi, Yun Young; Joo, Min Kyung; Park, Min Hee; Choi, Bo Gyu; Kang, Eun Young; Jeong, Byeongmoon

doi:10.1039/c0jm03894f

Cited by 31 publications

(24 citation statements)

References 42 publications

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“…Moreover, films with different percentages of MWCNT balanced the final pH value which is useful for biomedical engineering applications. Different parameters such as temperature have shown to affect the pH of CS . For this article, the experiments were done at 37°C because we are mostly interested in biomedical applications of the films.…”

Section: Resultsmentioning

confidence: 99%

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Mechanical and biological properties of chitosan/carbon nanotube nanocomposite films

Aryaei

Jayatissa

Jayasuriya

2013

J Biomedical Materials Res

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In this paper, different concentrations of multi-walled carbon nanotube (MWCNT) were homogeneously dispersed throughout the chitosan (CS) matrix. A simple solvent-cast method was used to fabricate chitosan films with 0.1, 0.5, and 1% of MWCNT with the average diameter around 30 nm. The CS/MWCNT films were characterized for structural, viscous and mechanical properties with optical microscopy, wide-angle X-ray diffraction, Raman spectroscopy, tensile test machine, and microindentation testing machine. Murine osteoblasts were used to examine the cell viability and attachment of the nanocomposite films at two time points. In comparison to the pure chitosan film, the mechanical properties, including the tensile modulus and strength of the films were greatly improved by increasing the percentage of MWCNT. Furthermore, adding MWCNT up to 1% increased the viscosity of the chitosan solution by 15%. However, adding MWCNT decreased the samples ductility and transparency. In biological point of view, no toxic effect on osteoblasts was observed in the presence of different percentages of MWCNT at day 3 and day 7. This investigation suggested MWCNT could be a promising candidate for improving chitosan mechanical properties without inducing remarkable cytotoxicity on bone cells.

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Section: Resultsmentioning

confidence: 99%

“…Different parameters such as temperature have shown to affect the pH of CS. 54 For this article, the experiments were done at 37 C because we are mostly interested in biomedical applications of the films.…”

Section: Raman Spectra Analysismentioning

confidence: 99%

Mechanical and biological properties of chitosan/carbon nanotube nanocomposite films

Aryaei

Jayatissa

Jayasuriya

2013

J Biomedical Materials Res

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“…pH‐sensitive thermogels have also been reported, adding an extra dimension of control in potential applications 16–18. Recently, polypeptide‐based and natural polymer‐based thermogelling copolymers have also been reported 3–5, 19, 20. These thermogelling copolymers have great applicative potential.…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18] Recently, polypeptide-based and natural polymer-based thermogelling copolymers have also been reported. [3][4][5]19,20 These thermogelling copolymers have great applicative potential. Recently, many different injectable gel systems have been presented as carriers of chemotherapeutic drugs for cancer treatments.…”

Section: Introductionmentioning

confidence: 99%

Sustained delivery of paclitaxel using thermogelling poly(PEG/PPG/PCL urethane)s for enhanced toxicity against cancer cells

Loh

Yee

Chia

2012

J Biomedical Materials Res

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A multiblock poly(ether ester urethane)s comprising poly(ε-caprolactone), poly(ethylene glycol), and poly(propylene glycol) segments was synthesized. The aqueous copolymer solution exhibited thermogelling behavior at a critical gelation concentration of 3 wt %. The chemical structure and molecular characteristic of the copolymers were studied by gel permeation chromatography, NMR, and fourier transform infrared spectroscopy (FTIR). Rheological characterizations on the thermogel were carried out. Drug release studies using paclitaxel showed that sustained drug release of more than 2 weeks can be achieved with this system. The paclitaxel-loaded gels showed efficiency in the control of the growth of HeLa cells when compared with the paclitaxel dissolved in solution or paclitaxel encapsulated in Pluronics F127. The results demonstrated that the copolymers could be potentially used in chemotherapeutic applications.

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“…An elegant work based also on polymer brushes was carried out by Jeong et al [20] by combining the "grafting from" and the "grafting to" approaches. This study proposed the synthesis of a pH/temperature sensitive poly(ethylene glycol)-poly(L-alanine) grafted chitosan (CS-g-(PA-PEG)) in two steps.…”

Section: Liquid-phase Peptide Synthesis Preparation Of Peptide-synthmentioning

confidence: 99%

Hybrid Block Copolymers Constituted by Peptides and Synthetic Polymers: An Overview of Synthetic Approaches, Supramolecular Behavior and Potential Applications

Morell

Puiggalı́

2013

Polymers

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Hybrid block copolymers based on peptides and synthetic polymers, displaying different types of topologies, offer new possibilities to integrate the properties and functions of biomacromolecules and synthetic polymers in a single hybrid material. This review provides a current status report of the field concerning peptide-synthetic polymer hybrids. The first section is focused on the different synthetic approaches that have been used within the last three years for the preparation of peptide-polymer hybrids having different topologies. In the last two sections, the attractive properties, displayed in solution or in the solid state, together with the potential applications of this type of macromolecules or supramolecular systems are highlighted.

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pH/temperature sensitive chitosan-g-(PA-PEG) aqueous solutions as new thermogelling systems

Cited by 31 publications

References 42 publications

Mechanical and biological properties of chitosan/carbon nanotube nanocomposite films

Mechanical and biological properties of chitosan/carbon nanotube nanocomposite films

Sustained delivery of paclitaxel using thermogelling poly(PEG/PPG/PCL urethane)s for enhanced toxicity against cancer cells

Hybrid Block Copolymers Constituted by Peptides and Synthetic Polymers: An Overview of Synthetic Approaches, Supramolecular Behavior and Potential Applications

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