pH sensitivity and ion sensitivity of hydrogels based on complex-forming chitosan/silk fibroin interpenetrating polymer network

Chen, Xin; Li, Wenjun; Zhong, Wei; Lu, Yue; Yu, Tao

doi:10.1002/(sici)1097-4628(19970912)65:11<2257::aid-app23>3.0.co;2-z

Cited by 105 publications

(44 citation statements)

References 7 publications

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“…By blending with other natural or synthetic polymers, such as cellulose (Freddi et al, 1995) or chitosan (Chen et al, 1997), silk fibroin can be processed into films or fiber silk fibroin scaffolds for a number of tissue engineering applications in skeletal tissues like bone and ligaments, and in connective tissues like skin. Moreover, SF films, fibers and gels have been investigated in vitro with different cell (Unger et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Cytocompatibility of regenerated silk fibroin film: a medical biomaterial applicable to wound healing

Liu

Jiang

Sheng

et al. 2010

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To explore the feasibility of using regenerated silk fibroin membrane to construct artificial skin substitutes for wound healing, it is necessary to evaluate its cytocompatibility. Methods: The effects of regenerated silk fibroin film on cytotoxicity, adhesion, cell cycle, and apoptosis of L929 cells, growth and vascular endothelial growth factor (VEGF) expression of ECV304 cells, and VEGF, angiopoietin-1 (Ang-1), platelet-derived growth factor (PDGF) and fibroblast growth factor 2 (FGF2) expression of WI-38 cells were assessed by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay, viable cell counting, flow cytometry (FCM), and enzyme-linked immunosorbant assay (ELISA). Results: We showed that the regenerated silk fibroin film was not cytotoxic to L929 cells and had no adverse influence on their adhesion, cell cycle or apoptosis; it had no adverse influence on the growth and VEGF secretion of ECV304 cells and no effect on the secretion of VEGF, Ang-1, PDGF and FGF2 by WI-38 cells. Conclusion: The regenerated silk fibroin film should be an excellent biomaterial with good cytocompatibility, providing a framework for reparation after trauma in clinical applications.

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Section: Discussionmentioning

confidence: 99%

Cytocompatibility of regenerated silk fibroin film: a medical biomaterial applicable to wound healing

Liu

Jiang

Sheng

et al. 2010

J. Zhejiang Univ. Sci. B

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“…Together, the ability to localize phenol reaction cascades [30] and the observation that the chemomechanical properties of these films are altered by these reactions suggests the potential to engineer chitosan films to perform finely tuned actuator functions. [43][44][45][46][47] …”

Section: Discussionmentioning

confidence: 99%

Mimicking Biological Phenol Reaction Cascades to Confer Mechanical Function

McDermott

Zhu

et al. 2006

Adv. Funct. Mater.

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Phenol reaction cascades are commonly used in nature to create crosslinked materials that perform mechanical functions. These processes are mimicked by electrochemically initiating a reaction cascade to examine if the mechanical properties of a biopolymer film can be predictably altered. Specifically, thin films (≈ 30–45 μm) of the polysaccharide chitosan are cast onto gold‐coated silicon wafers, the chitosan‐coated wafers are immersed in catechol‐containing solutions, and the phenol is anodically oxidized. The product of this oxidation is highly reactive and undergoes reaction with chitosan chains adjacent to the anode. After reaction, the flexible chitosan film can be peeled from the wafer. Chemical and physical evidence support the conclusion that electrochemically initiated reactions crosslink chitosan. When gold is patterned onto the wafer, the electrochemical crosslinking reactions are spatially localized and impart anisotropic mechanical properties to the chitosan film. Further, deswelling of chitosan films can reversibly transduce environmental stimuli into contractile forces. Films patterned to have spatial variations in crosslinking respond to such environmental stimuli by undergoing reversible changes in shape. These results suggest the potential to enlist electrochemically initiated reaction cascades to engineer chitosan films for actuator functions.

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“…Further, it was found that the gelation rate of hydrogel can be controlled by various factors such as calcium content, polymer concentration and gelation temperature (Chen et al, 1997). Chen et al (2011b) developed a novel natural semiinterpenetrating polymer network (semi-IPN) composed of chitosan crosslinked with glutaraldehyde and silk fibroin.…”

Section: Doxorubicin Poly[(2-ethoxy) Ethoxy Ethyl Vinyl Ether] (Poly(mentioning

confidence: 99%

Stimuli-responsive hydrogels in drug delivery and tissue engineering

Sood¹,

Bhardwaj²,

Mehta³

et al. 2014

Drug Delivery

311

194

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Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natural polymers which can absorb and retain a significant amount of water. Hydrogels are one of the most studied classes of polymer-based controlled drug release. These have attracted considerable attention in biochemical and biomedical fields because of their characteristics, such as swelling in aqueous medium, biocompatibility, pH and temperature sensitivity or sensitivity towards other stimuli, which can be utilized for their controlled zero-order release. The hydrogels are expected to explore new generation of self-regulated delivery system having a wide array of desirable properties. This review highlights the exciting opportunities and challenges in the area of hydrogels. Here, we review different literatures on stimuli-sensitive hydrogels, such as role of temperature, electric potential, pH and ionic strength to control the release of drug from hydrogels.

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pH sensitivity and ion sensitivity of hydrogels based on complex-forming chitosan/silk fibroin interpenetrating polymer network

Cited by 105 publications

References 7 publications

Cytocompatibility of regenerated silk fibroin film: a medical biomaterial applicable to wound healing

Cytocompatibility of regenerated silk fibroin film: a medical biomaterial applicable to wound healing

Mimicking Biological Phenol Reaction Cascades to Confer Mechanical Function

Stimuli-responsive hydrogels in drug delivery and tissue engineering

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