pH sensitive smart gels of cetylpyridinium chloride in binary solvent mixtures: phase behaviour, structure and composition

Ramakanth, Illa; Pištora, Jaromír

doi:10.1039/c5ra03478g

Cited by 7 publications

(5 citation statements)

References 60 publications

(90 reference statements)

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“…This is further supported by the interactions shown in the FTIR spectra of the gel, surfactant, and DES (Figure S2). Illa et al recently reported the formation of gel in the CPCl, for which they have used the binary solvent systems (CHCl 3 /H 2 O, CH 2 Cl 2 /H 2 O, and CCl 4 /H 2 O) . Similar to our work, these authors also tried gellation with several compositions of CPCl and binary solvent and discovered that, at 6% w/v, CPCl was transformed into the fibrillar gel …”

Section: Resultssupporting

confidence: 75%

Self-Healable, Injectable, and Conductive Supramolecular Eutectogel for the Encapsulation and Sustained Release of the Anticancer Drug Curcumin

Parsana

Kumar

Aswal

et al. 2022

ACS Appl. Eng. Mater.

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The intriguing properties such as high environmental compatibility of supramolecular gels made solely through reversible noncovalent interactions are of recent interest. To offer proof of concept for the new-age sustainable materials, herein we have designed the self-healable, injectable, and ionic conductive supramolecular eutectogel in natural deep eutectic solvent (NADES). The studied eutectogels were prepared by dissolving the pharmaceutically active cetylpyridinium chloride (C 16 PyCl) and cetylpyridinium bromide (C 16 PyBr) in the NADES. The NADES was formed by interacting choline chloride (ChCl) with mono-, di-, and trimeric acids, i.e., formic acid (FA), oxalic acid (OA), and citric acid (CA) through hydrogen bonding. The gelation kinetics of the eutectogel was assessed using turbidity measurement as a function of time, whereas the morphology and mechanical properties were assessed using scanning electron microscopy (SEM) and rheology. To further verify the shape and size of the aggregate within the eutectogel, small angle neutron scattering (SANS) was performed. The eutectogel offers excellent self-healing, injectable, and ionic conductive properties as well as excellent antimicrobial properties, and offers high encapsulation efficiency for curcumin. The sustained release characteristics and release kinetics of curcumin was also investigated. Gel phases, in particular, show high colloidal forces, which, along with their environmentally benign nature, make them a great candidate not only for biomedical applications but also for the industries that require high performance with minimal environmental impact.

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Section: Resultssupporting

confidence: 75%

Self-Healable, Injectable, and Conductive Supramolecular Eutectogel for the Encapsulation and Sustained Release of the Anticancer Drug Curcumin

Parsana

Kumar

Aswal

et al. 2022

ACS Appl. Eng. Mater.

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“…Moreover, in such a spectral range, the π-π* absorption transitions of the polyheteroaromatic structures derived from pyridinium units of the CPC head-group can also occur. Therefore, the absorption signal at 260 nm can additionally be indicative of some unreacted carbon precursor [ 46 ]. Such an attribution is confirmed by the UV-Vis absorption spectrum of a bare CPC solution ( Figure S1 ) that displays the characteristic absorption band in the UV range, while no other absorption feature can be detected in the visible portion of the spectrum.…”

Section: Resultsmentioning

confidence: 99%

Oil-Dispersible Green-Emitting Carbon Dots: New Insights on a Facile and Efficient Synthesis

et al. 2020

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Carbon dots (CDs) have been progressively attracting interest as novel environmentally friendly and cost-effective luminescent nanoparticles, for implementation in light-emitting devices, solar cells, photocatalytic devices and biosensors. Here, starting from a cost-effective bottom-up synthetic approach, based on a suitable amphiphilic molecule as carbon precursor, namely cetylpyridinium chloride (CPC), green-emitting CDs have been prepared at room temperature, upon treatment of CPC with concentrated NaOH solutions. The investigated method allows the obtaining, in one-pot, of both water-dispersible (W-CDs) and oil-dispersible green-emitting CDs (O-CDs). The study provides original insights into the chemical reactions involved in the process of the carbonization of CPC, proposing a reliable mechanism for the formation of the O-CDs in an aqueous system. The ability to discriminate the contribution of different species, including molecular fluorophores, allows one to properly single out the O-CDs emission. In addition, a mild heating of the reaction mixture, at 70 °C, has demonstrated the ability to dramatically decrease the very long reaction time (i.e. from tens of hours to days) at room temperature, allowing us to synthesize O-CDs in a few tens of minutes while preserving their morphological and optical properties.

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“…The objective of the present work is to investigate the self-assembly behaviour of cetyltrimethylammonium bromide (CTAB) and its gelation ability in various solvent combinations. Following our recent work [ 35 ] on pH-sensitive smart gels formed from CTAB, the present investigation explores the physico-chemical, structural and thermal properties of the CTAB gels from binary solvent mixture of toluene and water. The as-prepared CTAB gel has been organized into a lamellar gel owing to the presence of hydrophobic interactions in the proposed fibrous gel network structure [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Solvent selective gelation of cetyltrimethylammonium bromide: structure, phase evolution and thermal characteristics

Nagarjuna,

Ramakanth

2024

R. Soc. Open Sci.

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We report herein the gelation behaviour of cetyltrimethylammonium bromide (CTAB), a cationic surfactant, in a variety of solvent compositions. A turbid gel of CTAB in a binary solvent mixture at a critical composition was observed to be 1 : 3 v/v toluene : water. The molecular structure of the as-formed gel was investigated by X-ray diffraction and microscopic techniques, namely, optical and polarizing microscopy, scanning electron microscopy and small-angle X-ray scattering (SAXS). The phase evolution has been studied using UV–visible transmittance measurements and the thermal characteristics of the gel by differential scanning calorimetry measurements. SAXS studies, in conjunction with molecular modelling, revealed the gel to assemble as lamellae with high interdigitation of bilayer assembly of CTAB molecules with predominant non-covalent interactions, where the gel lamellae were inferred from the interplanar spacings. Rheological studies revealed the viscoelastic nature of the CTAB gels. The ability to form a gel has been evaluated in several polar solvents, such as methanol and chloroform, and non-polar solvents, such as toluene and carbon tetrachloride.

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pH sensitive smart gels of cetylpyridinium chloride in binary solvent mixtures: phase behaviour, structure and composition

Cited by 7 publications

References 60 publications

Self-Healable, Injectable, and Conductive Supramolecular Eutectogel for the Encapsulation and Sustained Release of the Anticancer Drug Curcumin

Self-Healable, Injectable, and Conductive Supramolecular Eutectogel for the Encapsulation and Sustained Release of the Anticancer Drug Curcumin

Oil-Dispersible Green-Emitting Carbon Dots: New Insights on a Facile and Efficient Synthesis

Solvent selective gelation of cetyltrimethylammonium bromide: structure, phase evolution and thermal characteristics

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