pH-sensitive release of silver nanoparticles from titanium dioxide nanotubes array

Liu, Jinsong; Lihua, Xu; Liu, Chuantong; Yifan, Jin; Hu, Xiaohui; Dong, Yue

doi:10.3389/conf.fbioe.2016.01.01742

Cited by 1 publication

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“…TiO 2 NPs can accumulate in the reproductive organs of mammals in different ways, affecting the development of ovum and sperm, damaging the reproductive organs, and endangering the growth and development of offspring (Minghui et al, 2023). There is evidence that the absorption of TiO 2 NPs may cross the placenta and enter fetal tissue, leading to reproductive and developmental toxicity (Guo et al, 2009; Ogunsuyi et al, 2020; Posgai et al, 2011).…”

Section: Toxicological Impacts Of Nano Titanium Dioxide On Major Targ...mentioning

confidence: 99%

The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity

Li,

Tang

2023

J of Applied Toxicology

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Nano‐titanium dioxide (TiO2NPs) is widely used for its extremely high stability, corrosion resistance, and photocatalytic properties and has penetrated into various fields of production and life. Assessing its toxicity to different organs should be a key part of preclinical toxicity assessment of TiO2NPs, which is relatively incomprehensive yet. Therefore, this review focuses on the toxic effects of TiO2NPs on various organs in mammals and biological mechanisms from different organs. The commonality of toxic effects on various target organs reflected in tissue structure damage and dysfunction, such as liver damage and dysfunction; pulmonary fibrosis; and renal impairment (including hematuria and nephritis); damage of brain tissue and neurons; alteration of intestinal villi; and weight loss. And effects on the reproductive system are affected by different sexes, including ovarian dysfunction, testicular development damage, and sperm viability reduction. We believe that the toxic mechanisms of TiO2NPs in target organs have commonalities, such as oxidative stress, inflammatory responses, and organelle damage. However, different target organ toxicities also have their specificities. TiO2NPs disturb the intestinal flora and cause undesirable changes in feces products. And in spleen are infiltration of neutrophils and lymphadenopathy and eventually immune deficiency. Although the toxic pathways are different, but there may be a close link between the different toxic pathways. In this article, the main manifestations of the toxic effects of titanium dioxide nanoparticles on major mammalian organs are reviewed, in order to provide basic data for their better application from a medical perspective.

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Section: Toxicological Impacts Of Nano Titanium Dioxide On Major Targ...mentioning

confidence: 99%

The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity

Li,

Tang

2023

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

pH-sensitive release of silver nanoparticles from titanium dioxide nanotubes array

Cited by 1 publication

References 0 publications

The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity

The toxicological effects of nano titanium dioxide on target organs and mechanisms of toxicity

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