pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma

Glycyrrhetinic Acid-Mediated Polymeric Drug Delivery Targeting the Acidic Microenvironment of Hepatocellular Carcinoma

“…The ex-situ liver tumor bearing model was established on BALB/c nude mice by HCC cell transplantation as described (32). When the volume of transplanted tumor reached approximately 500 mm 3 , animals were randomly divided into four groups: saline control, free AGP, AGP/PP micelles, and AGP/GA-PPP micelles (n=6 animals per group).…”

Ketoprofen-loaded pomegranate seed oil nanoemulsion stabilized by pullulan: Selective antiglioma formulation for intravenous administration

“…Hydrophobically modified pullulan derivatives have been used in preparing nanostructured systems such as liposomes and magnetic nanoparticles [26,27]. Besides, it has been used in nanoparticles for the treatment of hepatocellular carcinoma providing the bind between the particles and hepatic asialoglycoprotein receptors, lowering hemolytic potential and increasing blood circulation [28][29][30]. On the other hand, no reports could be found reporting the use of this biopolymer as a stabilizer agent for NE or the use of these formulations for the treatment of glioblastoma multiform.…”

Self-assembled nanocomplexes of anionic pullulan and polyallylamine for DNA and pH-sensitive intracellular drug delivery

“…Pullulan was chosen to develop anionic polymer and drug conjugation because it has been widely explored for various biomedical applications such as tissue engineering, targeted drug and gene delivery due to its unique biocompatibility profile (Prajapati et al 2013). Pullulan derivatives with various cationic polymers such as protamine, polyethyleneimine, spermine, and glycidyl trimethyl ammonium chloride have been explored for gene delivery to increase hemocompatibility and efficiency of a gene delivery vector component (Priya et al 2014;Rekha and Sharma 2011;Thakor et al 2009;Thomsen et al 2011) Besides that, various targeted pullulandrug conjugates have been investigated for improving efficacy of cytotoxic drugs on tumor site along with fewer side effects on normal tissues (Li et al 2013a, b;Scomparin et al 2011;Wang et al 2013). Carboxylmethylated pullulan (CMP) is an anionic derivative of pullulan, which has been widely explored for biomedical applications (Dulong et al 2012;Pereiraa, et al 2014;Mocanu et al 2014).…”