pH-Sensitive nanogels based on the electrostatic self-assembly of radionuclide<sup>131</sup>I labeled albumin and carboxymethyl cellulose for synergistic combined chemo-radioisotope therapy of cancer

Liu, Kefeng; Zheng, Dan; Zhao, Jingyang; Tao, Yinghua; Wang, Yingsa; He, Jing; Lei, Jiandu; Xi, Xingjun

doi:10.1039/c8tb01295d

Cited by 32 publications

(13 citation statements)

References 38 publications

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“…Their drug release increased at acidic pH which protected normal tissues from toxic effects. At pH 7.4 the cumulative release of CPT was almost half than the one at pH 5 which was attributed to the weakening of electrostatic interactions between the drug and the NGs [ 91 ]. Electrostatic complexation between fibrinogen (Fbg) and HA were stabilized by thermal treatment taking advantage of the thermally-induced intermolecular associations between Fbg molecules [ 71 ].…”

Section: Medical Applications Of Polysaccharide Ngs and Mgsmentioning

confidence: 99%

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

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Polysaccharides are natural polymers with hydrophilic, biocompatible and biodegradable characteristics and have many opportunities in the food and pharmaceutical sectors. This review focuses on the field of nano and microstructures whose internal structure is based on networked polysaccharide chains in 3D i.e., polysaccharide nanogels (NGs) and microgels (MGs). As it is observed the number of articles on NGs and MGs in peer reviewed scientific journals has been increasing over the last two decades. At the same time, the relative contribution of polysaccharides in this field is gaining place. This review focuses on the different applied methods for the fabrication of a variety of polysaccharide-based NGs and MGs and aims to highlight the recent advances on the subject and present their potentials and properties with regards to their integration in aspects of medicinal and food sciences. The presentation of the recent advances in the application of polysaccharide NGs and MGs is divided in materials with potential as emulsion stabilizers and materials with potential as carriers of bioactives. For applications in the medical sector the division is based on the fabrication processes and includes self-assembled, electrostatically complexed/ionically crosslinked and chemically crosslinked NGs and MGs. It is concluded that many advances are expected in the application of these polysaccharide-based materials and in particular as nutrient-loaded emulsion stabilizers, viscosity modifiers and co-assembled structures in combination with proteins.

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Section: Medical Applications Of Polysaccharide Ngs and Mgsmentioning

confidence: 99%

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

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“…Nanogels based on carboxymethyl cellulose (CMC) for cancer drug release demonstrated colloidal stability, pH sensitivity, and better drug delivery at pH 5.0. 126 Nanogels synthesized from methacrylated monocarboxylic sugarcane bagasse cellulose (MAMC-SBC) have shown particle stability and multi-responsive characteristics (responsive to redox, pH, and temperature) for anti-cancer drug delivery systems. 127 In addition, the drug release rate through the hydrogel/nanogels can also be regulated by applying an electric field for non-ionic drugs, such as 5-fluorouracil, an anti-cancer drug.…”

Section: Application Of Cellulose-based Hydrogelsmentioning

confidence: 99%

Cellulose: a fascinating biopolymer for hydrogel synthesis

Bhaladhare

Das

2022

J. Mater. Chem. B

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“…Through electrostatic and host‐guest interactions, the cellulosic drug‐loaded hydrogel beads have potential application in pharmaceutical. Recently, Liu et al 27 . prepared pH‐sensitive nanogels based on CMC and bovine serum albumin with a simple and green electrostatic interaction approach, which offered an effective strategy for combining chemoradioisotope therapy of cancer.…”

Section: Design Of Supramolecular Hydrogels Based On Cellulosementioning

confidence: 99%

Cellulose‐based hydrogels regulated by supramolecular chemistry

Zeng

Sun

et al. 2021

SusMat

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Supramolecular hydrogels based on cellulose attract increasing attention because of their novel structures and broad potential applications. In this review, hydrogels composed of cellulose are summarized according to category of supramolecular interactions in the networks including hydrogen bonds, electrostatic interactions, host‐guest interactions, and others. Supramolecular cellulose‐based hydrogels constructed by noncovalent bonding usually exhibit environmental friendliness, designing flexibility and diverse functions, and their properties are variable with incorporating different interactions in hydrogel networks. Moreover, with proper structures and networks, the supramolecular cellulose‐based hydrogels are adaptable in diverse fields of research and practical applications, such as self‐healing, shape memory, drug delivery, and some other renewable/sustainable materials. The future developments and challenges of the supramolecular hydrogels based on cellulose are discussed as well.

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pH-Sensitive nanogels based on the electrostatic self-assembly of radionuclide¹³¹I labeled albumin and carboxymethyl cellulose for synergistic combined chemo-radioisotope therapy of cancer

Abstract: Development of biocompatible and biodegradable nanocarriers with multiple functionalities has attracted great interest in recent years.

Cited by 32 publications

References 38 publications

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Cellulose: a fascinating biopolymer for hydrogel synthesis

Cellulose‐based hydrogels regulated by supramolecular chemistry

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pH-Sensitive nanogels based on the electrostatic self-assembly of radionuclide131I labeled albumin and carboxymethyl cellulose for synergistic combined chemo-radioisotope therapy of cancer

Abstract: Development of biocompatible and biodegradable nanocarriers with multiple functionalities has attracted great interest in recent years.

Cited by 32 publications

References 38 publications

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Cellulose: a fascinating biopolymer for hydrogel synthesis

Cellulose‐based hydrogels regulated by supramolecular chemistry

Contact Info

Product

Resources

About

pH-Sensitive nanogels based on the electrostatic self-assembly of radionuclide¹³¹I labeled albumin and carboxymethyl cellulose for synergistic combined chemo-radioisotope therapy of cancer