pH-Sensitive Mixed Micelles Assembled from PDEAEMA-PPEGMA and PCL-PPEGMA for Doxorubicin Delivery: Experimental and DPD Simulations Study

Yang, Chufen; Liu, Wenyao; Xiao, Jiayu; Yuan, Cong; Chen, Yaoxi; Guo, Juan; Yue, Hangbo; Zhu, Dunming; Lin, Wenjing; Tang, Sheng-Qiu; Dong, Xiaoying

doi:10.3390/pharmaceutics12020170

Cited by 18 publications

(23 citation statements)

References 42 publications

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“…From Table 2 , DOX-loaded micelles displayed the larger particle sizes than their corresponding blank polymeric micelles, and the larger particle sizes were obtained with more DOX fed to the polymeric micelles. Notably, the particle sizes of DOX-loaded micelles were less than 200 nm, which was reportedly beneficial to the perfusion and accumulation of drug-loaded micelles in tumor tissues by enhanced permeation and retention (EPR) mechanism [ 39 , 40 , 41 ]. As the feed ratio of DOX/polymer increased, the LCs of DOX-loaded micelles accordingly increased, reflecting that the feed ratio of DOX/polymer had an important impact on LCs.…”

Section: Resultsmentioning

confidence: 99%

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

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Four-arm star-shaped (denoted as ‘S’) polymer adamantane-[poly(lactic-co-glycolic acid)-b-poly(N,N’-diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as ‘L’) counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for anticancer drug delivery. Two types of polymeric micelles exhibited strong pH-responsiveness and good drug loading capacity (21.6% for S-PLGA-D-P and 22.9% for L-PLGA-D-P). Using doxorubicin (DOX) as the model drug, their DOX-loaded micelles displayed well controlled drug release behavior (18.5–19.0% of DOX release at pH 7.4 and 77.6–78.8% of DOX release at pH 5.0 within 80 h), good cytocompatibility against NIH-3T3 cells and effective anticancer efficacy against MCF-7 cells. However, the star-shaped polymeric micelles exhibited preferable stability, which was confirmed by the lower critical micelle concentration (CMC 0.0034 mg/mL) and decrease rate of particle sizes after 7 days incubation (3.5%), compared with the linear polymeric micelle L-PLGA-D-P (CMC 0.0070 mg/mL, decrease rate of particle sizes was 9.6%). Overall, these developed polymeric micelles have promising application as drug delivery system in cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

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“…Many PDEAEMA copolymeric systems have been utilized to deliver anticancer drugs. For example, recently, DOX delivery was achieved using a mixture of polymers, i.e., poly ( N,N -diethylaminoethyl methacrylate)- b -poly(poly(ethylene glycol) methyl ether methacrylate) (PDEAEMA-PPEGMA) with polycaprolactone- b -poly (poly(ethylene glycol) methyl ether methacrylate) (PCL-PPEGMA) [ 114 ]. Inflamed tissues, just like cancerous cells, possess a unique acidic environment that can be utilized to in the development of targeting scaffolds.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…After this, molecular dynamic simulations were carried out for the obtained three cells using the Forcite module. 29 The NVT ensemble was selected for the generation of trajectories under a constant particle number, cell volume, and temperature (25 °C). The time of simulation and step were 1000 ps and 1 fs, respectively, each frame was delivered every 1000 steps, and the pressure control method was Berendsen.…”

Section: Simulationsmentioning

confidence: 99%

Using Amphiphilic Polymer Micelles as the Templates of Antisolvent Crystallization to Produce Drug Nanocrystals

et al. 2022

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Biocompatible and biodegradable amphiphilic polymeric micelles (PLA-CMCS-g-OA) were prepared by surface grafting of oleic acid and polylactic acid onto carboxymethyl chitosan and were used as templates for the crystallization of camptothecin. The camptothecin (CPT) nanocrystals prepared by the novel micelle-templated antisolvent crystallization (mt-ASC) method demonstrated higher crystallinity, narrower particle size distribution, and slower release characteristic than those prepared by conventional antisolvent crystallization (c-ASC) using a high initial concentration and fast addition rate. In particular, the CPT release behavior of mt-ASC products in phosphate buffer solutions presented a pH-responsive characteristic with the increasing release rate of CPT under lower pH conditions. This work confirmed that amphiphilic nanomicelle-templated crystallization was an effective method for preparing drug nanocrystals.

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pH-Sensitive Mixed Micelles Assembled from PDEAEMA-PPEGMA and PCL-PPEGMA for Doxorubicin Delivery: Experimental and DPD Simulations Study

Cited by 18 publications

References 42 publications

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Using Amphiphilic Polymer Micelles as the Templates of Antisolvent Crystallization to Produce Drug Nanocrystals

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