pH sensitive interpenetrating network microgels of sodium alginate‐acrylic acid for the controlled release of ibuprofen

Abstract

pH-Sensitive interpenetrating network (IPN) microgels (MGs) of sodium alginate (NaAlg) and acrylic acid have been prepared by using water-in-oil (W/O) emulsion technique. The MGs were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffractometer (X-RD). The release of ibuprofen (IB), an anti-inflammatory drug, from these MGs was studied in pH 1.2 and 7.4 media. MG network consists of NaAlg, which disintegrates in the intestinal fluid, while poly(acrylic acid) provides pH-sensitivity to the microgel network. The system developed in this study showed a pH-sensitivity for the release of IB, which was attributed to the diffusion controlled release of the drug through the surfaces of MGs that undergo disintegration after swelling, depending upon the chemical composition of MGs and pH of the medium.

Preparation and Characterization of IPN Microspheres for Controlled Delivery of Naproxen

“…The release rates of NS to an external medium are more difficult compared to the NaAlg microspheres. Similar results can be found from the published reports [16,17]. In the study of Krishna Rao and coworkers, controlled release of cefadroxil from IPN microspheres based on chitosan, acrylamide-graftedpoly(vinyl alcohol) and hydrolyzed acrylamide-graftedpoly(vinyl alcohol) were investigated.…”

“…As the amount of drug increased from 20% to 50%, the % cumulative release rate increased from 26 to 84. This is obvious that as the amount of NaAlg increases in the matrix, diffusion of NS occur faster and higher from the swollen IPN [17]. Ramesh Babu and coworkers prepared IPN microgels of sodium alginate-acrylic acid for the controlled release of ibuprofen.…”

Infuence of Microstructure in Drug Release Behavior of Silica Nanocapsules

“…The controlled release of ibuprofen has also been studied through the interpenetrating network of different polymeric microgels of sodium alginate and acrylic acid [19, 20]. For these materials it was reported that a 70% drug release was reached after 6 h and between 85 and 100% after 12.…”

Pain Management Via Local Anesthetics and Responsive Hydrogels

“…Functional groups often found in pH sensitive hydrogels are weak acids or bases such as carboxylic acid, phosphoric acid, sulfonic acid and amines [30]. The most frequently studied pH responsive hydrogels are poly(acrylic acid) [70], poly(methacrylic acid) [71], poly(ethylene imine) [72], chitosan [73], poly(L–lysine) [74] and poly(L–histidine) due to the presence of carboxylic or amino groups in these polymers [75]. One of the limitations inherent in synthetic pH-sensitive hydrogels is that they are not biodegradable and therefore must be removed, thereby limiting their in vivo applications [46].…”