pH sensitive insulin-loaded nanohydrogel increases the effect of oral insulin in diabetic rats

Karnoosh-Yamchi, Jalil; Rahmati-Yamchi, Mohammad; Akbarzadeh, Abolfazl; Davaran, Soodabeh; Rahimi, Ali; Garnoosh, Khalil; Bahmani, Zahra; Ashoori, Mohammad Reza; Mobasseri, Majid

doi:10.1080/21691401.2016.1216859

Cited by 8 publications

(2 citation statements)

References 40 publications

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“…The physiological microenvironment of the bone is particularly suitable for cancer cell adhesion and proliferation. , Therefore, many cancers, such as human breast or lung cancer, easily metastasize to bone, leading to the formation of secondary bone tumors . Alendronate (ALN) is a new bisphosphonate drug that is mainly used in the treatment of osteoporosis and metastatic bone tumors .…”

Section: Introductionmentioning

confidence: 99%

In Vivo Evaluation of Reduction-Responsive Alendronate-Hyaluronan-Curcumin Polymer-Drug Conjugates for Targeted Therapy of Bone Metastatic Breast Cancer

et al. 2018

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Many cancers, such as human breast cancer and lung cancer, easily metastasize to bones, leading to the formation of secondary tumors in advanced stages. On the basis of the CD44-targeted effect of oHA and the bone-targeted effect of ALN, we prepared a reduction-responsive, CD44 receptor-targeting and bone-targeting nanomicelle, called CUR-loaded ALN-oHA-S-S-CUR micelles. In this study, we aimed to evaluate the antitumor activity and bone-targeting ability of CUR-loaded ALN-oHA-S-S-CUR micelles. The in vivo experiment results showed that a larger number of micelles was gathered in the bone metastatic tumor tissue and reduced the bone destruction. The CUR-loaded ALN-oHA-S-S-CUR micelles markedly inhibited the tumor growth. So the CUR-loaded ALN-oHA-S-S-CUR micelles constitute a promising drug delivery system for bone tumor therapy.

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Section: Introductionmentioning

confidence: 99%

In Vivo Evaluation of Reduction-Responsive Alendronate-Hyaluronan-Curcumin Polymer-Drug Conjugates for Targeted Therapy of Bone Metastatic Breast Cancer

et al. 2018

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“…The number of cases with diabetes mellitus was predictable to increase 366 million in 2030 [1,2]. The complexities associated with chronic diabetes mellitus consist of retinopathy, neuropathy, nephropathy, cardiomyopathy and vasculopathy [3][4][5]. Diabetes mellitus is the key root of renal failure, and about 20-30% of diabetic patients were proposed to develop indication of diabetic nephropathy [6].…”

Section: Introductionmentioning

confidence: 99%

Development and biological evaluation of vesicles containing bile salt of telmisartan for the treatment of diabetic nephropathy

Ahad

Raish

Ahmad

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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The aim of present study was to develop and evaluate vesicles containing bile salt formulation of telmisartan for the treatment of diabetic nephropathy. Different vesicles containing bile salt formulations were developed by varying ratios of soybean phosphatidylcholine and sodium deoxycholate. Prepared formulations were characterized for their size, polydispersity index, zeta potential, morphology and entrapment efficiency. Further, the renoprotective outcome of optimized formulation was studied in streptozotocin-induced diabetic nephropathy rat model. Results of the present study demonstrated that the average vesicles size, polydispersity index, zeta potential and entrapment efficiency were found to be in the range of 64.98 ± 1.40 to 167.60 ± 6.46 nm, 0.02 ± 0.04 to 0.31 ± 0.01, -24.30 ± 1.39 to -42.60 ± 6.67 mV and 29.68 ± 1.08% to 77.21 ± 0.52%, respectively. Further, the best chosen formulation F4 presented vesicles size, polydispersity index, zeta potential and entrapment efficiency of 64.98 ± 1.40 nm, 0.24 ± 0.02, -35.40 ± 1.48 mV and 77.21 ± 0.52%, respectively. In addition, formulation F4 improved the biological indices in streptozotocin-induced diabetic nephropathy in rats. It was concluded that prepared formulation exerts a valuable results on diabetic nephropathy and it may be a potential pharmaceutical dosage form for the treatment of diabetic nephropathy.

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Advanced Nanostructures for Oral Insulin Delivery

Sabu¹,

Pramod²

2020

Environmental Chemistry for a Sustainable World

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pH sensitive insulin-loaded nanohydrogel increases the effect of oral insulin in diabetic rats

Abstract: Our study confirms that insulin has been able to pass from the stomach acid barrier by nanohydrogel and be absorbed from the intestine.

Cited by 8 publications

References 40 publications

In Vivo Evaluation of Reduction-Responsive Alendronate-Hyaluronan-Curcumin Polymer-Drug Conjugates for Targeted Therapy of Bone Metastatic Breast Cancer

In Vivo Evaluation of Reduction-Responsive Alendronate-Hyaluronan-Curcumin Polymer-Drug Conjugates for Targeted Therapy of Bone Metastatic Breast Cancer

Development and biological evaluation of vesicles containing bile salt of telmisartan for the treatment of diabetic nephropathy

Advanced Nanostructures for Oral Insulin Delivery

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