pH-Sensitive gold nanoclusters: preparation and analytical applications for urea, urease, and urease inhibitor detection

Deng, Hao‐Hua; Wu, Gang-Wei; Zou, Zhiqiang; Peng, Hua-Ping; Liu, Ailin; Lin, Xinhua; Xia, Xing‐Hua; Chen, Wei

doi:10.1039/c5cc00702j

Cited by 87 publications

(43 citation statements)

References 32 publications

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“…Furthermore, there was no peak displayed around 942.0 eV, demonstrating the absence of Cu(II) in Cu NCs [ 52 ]. In addition, the S 2p3/2 peak located at 166.3 eV confirmed the covalent interaction of Cu NCs with the SH group ( Figure 5 E) [ 53 ]. The peaks of S(1s), C(1s), N(1s), Na, O(1s), Cu (2p), and Na(1s) are clearly visible in the spectrum ( Figure 5 F), further indicating that Cu NCs are stabilized by GSH [ 54 ].…”

Section: Resultsmentioning

confidence: 97%

Facile Synthesis of Ultrastable Fluorescent Copper Nanoclusters and Their Cellular Imaging Application

Zhang

Abbas

et al. 2020

Nanomaterials

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Copper nanoclusters (Cu NCs) are generally formed by several to dozens of atoms. Because of wide range of raw materials and cheap prices, Cu NCs have attracted scientists’ special attention. However, Cu NCs tend to undergo oxidation easily. Thus, there is a dire need to develop a synthetic protocol for preparing fluorescent Cu NCs with high QY and better stability. Herein, we report a one-step method for preparing stable blue-green fluorescent copper nanoclusters using glutathione (GSH) as both a reducing agent and a stabilizing agent. High-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and electrospray ionization mass spectrometer (ESI-MS) were used to characterize the resulting Cu NCs. The as-prepared Cu NCs@GSH possess an ultrasmall size (2.3 ± 0.4 nm), blue-green fluorescence with decent quantum yield (6.2%) and good stability. MTT results clearly suggest that the Cu NCs@GSH are biocompatible. After incubated with EB-labeled HEK293T cells, the Cu NCs mainly accumulated in nuclei of the cells, suggesting that the as-prepared Cu NCs could potentially be used as the fluorescent probe for applications in cellular imaging.

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Section: Resultsmentioning

confidence: 97%

Facile Synthesis of Ultrastable Fluorescent Copper Nanoclusters and Their Cellular Imaging Application

Zhang

Abbas

et al. 2020

Nanomaterials

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“…For example, it is proved that the luminescence of NAC‐Au NCs is extremely sensitive to pH. [90] When the pH changed from 6.05 to 6.40, a significant decrease in luminescence was recorded on NAC‐Au NCs. This ultra‐sensitive pH responsive characteristic can be used to develop an effective sensing platform for urea, urease, and urease inhibitors.…”

Section: Biosensing Strategiesmentioning

confidence: 99%

Luminescent metal nanoclusters: Biosensing strategies and bioimaging applications

et al. 2021

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Metal nanoclusters (MNCs) are ultrasmall metal‐organic aggregates, composed of a metal core less than 2 nm and a protecting shell of metal‐organic ligand motifs. The controlled aggregation of metal atoms (in the cluster core) and metal‐organic ligand motifs (around the cluster core) renders MNCs with numerous molecule‐like properties, among which strong and bright luminescence has attracted extensive basic and applied interests. It has now known that aggregation‐induced emission is a feasible mechanism for controlling luminescence of MNCs, which makes it particularly useful in biosensing and bioimaging applications. Although the luminescence fundamentals and design principles largely determine the practicality and effectiveness of MNCs in biosensing and bioimaging applications, a systematic summary of this topic is lacking in the current literature. In this review, we aim to provide a concise discussion of the latest developments in biosensing and bioimaging applications of luminescent MNCs, highlighting their luminescence mechanisms, biosensing principles, and bioimaging strategies. Specifically, we first introduce the recent advances in the synthetic chemistry of MNCs, and then briefly discuss the luminescence fundamentals of MNCs. Then the design strategy and practicality of luminescent MNCs in biosensing and bioimaging applications are exemplified. We conclude the review with our perspectives on the further development of MNC‐based optical probes in biosensing and bioimaging applications. Our review is expected to provide guidance for the future practice of designing and synthesizing luminescent MNCs for biomedical and other applications.

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“…However, the fluorescence spectroscopy technology has been applied to the detection of a variety of food additives attributed to its fast responsivity, simple operation, and high sensitivity. [15][16][17] Due to good luminescence and small size, nanomaterial fluorescent probes have gradually received attention in the detection of small molecules in food. 18,19 Although nanomaterials have good fluorescence properties, their synthesis process are complicated, and the synthesis precursor materials are toxic.…”

Section: Introductionmentioning

confidence: 99%

A Lanthanide Complex Fluorescent Probe for the Detection of Melamine

et al. 2021

Appl Spectrosc

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Melamine is a kind of small molecule compound, which has been illegally adulterated in dairy food because of the rich nitrogen content and stable chemical properties. Therefore, the detection of melamine is of great significance to food safety and human's health protection. Melamine can emit weak fluorescence, making it difficult to detect melamine directly. However melamine can significantly enhance the emission of the tetracycline-europium (EuTC) complex at a wavelength of 616 nm, hence this work uses EuTC complex as a fluorescent probe to detect melamine. According to the characterizations of absorption spectra, molecular electrostatic potential distribution and the time-resolved spectra, we speculated that tetracycline and melamine may form a complex through hydrogen bonding interaction, causing the melamine closer approach to Eu3+ and reducing the non-radiative energy loss of water molecules to EuTC complex, which significantly enhanced the fluorescence intensity of EuTC. The fluorescence intensity with melamine concentration in the range of 0.5~40 Î¼M shows a good linear relationship, and the correlation coefficient is 0.9951 with the detection limit of 0.0785 Î¼M, which shows a high sensitivity in detection of melamine. As far as we know, EuTC complex is the first time that has been used as a fluorescent probe to detect melamine, which provides a supplement and extension for the detection of melamine in fluorescence spectroscopy.

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pH-Sensitive gold nanoclusters: preparation and analytical applications for urea, urease, and urease inhibitor detection

Cited by 87 publications

References 32 publications

Facile Synthesis of Ultrastable Fluorescent Copper Nanoclusters and Their Cellular Imaging Application

Facile Synthesis of Ultrastable Fluorescent Copper Nanoclusters and Their Cellular Imaging Application

Luminescent metal nanoclusters: Biosensing strategies and bioimaging applications

A Lanthanide Complex Fluorescent Probe for the Detection of Melamine

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