pH sensitive functionalized hyperbranched polyester based nanoparticulate system for the receptor-mediated targeted cancer therapy

Bal‐Öztürk, Ayça; Cevher, Erdal; Pabucçuoğlu, Serhat; Özgümüş, Saadet

doi:10.1080/00914037.2018.1452226

Cited by 13 publications

(8 citation statements)

References 79 publications

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“…[2][3][4][5] The anticancer drug 5-fluorouracil (5FU) is one of the most commonly used drugs for treating breast cancer, and various folate (FA)-based controlled drug delivery systems (DDSs) have been developed to deliver 5FU to MCF-7 breast cancer cells. 6,7 Several biodegradable polymer-based materials, including gellan gum, 8 poly(D,Llactic-co-glycolic acid), 9 polycaprolactone, 10 and L-lysinemodified hyperbranched polyester, 11 have been developed as 5FU delivery platforms to enhance the anticancer activity of 5FU. However, the size of these polymeric platforms is a major concern with regard to cell internalization of drugincorporated carriers.…”

Section: Introductionmentioning

confidence: 99%

<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>

Gajendiran

Kim

et al. 2019

IJN

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BackgroundSurface functionalization of gold nanoparticles (AuNPs) has emerged as a promising field of research with enormous biomedical applications. The folate (FA)-attached polymer-gold nanoconjugates play vital role in targeting the cancer cells.MethodsAuNPs were synthesized by using di- or tri-carboxylate-polyethylene glycol (PEG) polymers, including citrate-PEG (CPEG), malate-PEG (MAP), and tartrate-PEG (TAP), as a reducing and stabilizing agent. After synthesis of polymer-AuNPs, the freely available hydroxyl and carboxylate groups of CPEG, MAP, and TAP were used to attach a cancer cell-targeting agent, FA, via a 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxy succinimide coupling reaction to obtain FA-CPEG-AuNP, FA-MAP-AuNP, and FA-TAP-AuNP nanocon-jugates, respectively. The 5-fluorouracil (5FU) was attached to π back-bonded carbonyl oxygens of the nanoconjugates, and the in vitro drug release profile was studied by high pressure liquid chromatography. Biocompatibility profiles of the FA-CPEG-AuNP, FA-MAP-AuNP, and FA-TAP-AuNP nanoconjugates were investigated using adult human dermal fibroblasts. Anti-breast cancer activity of 5FU-loaded nanoconjugates was investigated using MCF-7 breast cancer cells.ResultsX-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses confirmed that AuNPs attached to CPEG, MAP, or TAP via the formation of π back bonding between AuNPs and the ester carbonyl group. The π back-bonded nanoconjugates exhibited sustained release of 5FU up to 27 days. FA-MAP-AuNPs exhibited an IC50 at 5 µg/mL, while FA-CPEG-AuNPs and FA-TAP-AuNPs showed the IC50 at 100 µg/mL toward MCF-7 cancer cells.ConclusionThe developed polymer π back-bonded multifunctional gold nanoconjugates could be used as a potential drug delivery system for targeting MCF-7 cancer cells.

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Section: Introductionmentioning

confidence: 99%

<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>

Gajendiran

Kim

et al. 2019

IJN

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“…The solid polymer matrix has a limited capacity to entrap certain drug molecule. Hence, further increase in the OXC concentration exceeding a threshold resulted in more drug loss during fabrication process and led to decrease in encapsulation efficiency (Bal Öztürk, Cevher, Pabuccuoğlu, & Özgümüş, ; Dong & Feng, ). Furthermore, the encapsulation efficiency found to be enhanced with the increasing diameter of nanoparticles in the accordance with literature (Mainardes & Evangelista, ).…”

Section: Resultsmentioning

confidence: 99%

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Alarçin

Demirbağ

Karslı-Çeppioğlu

et al. 2020

Drug Development Research

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Oxaceprol is well-defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis. In the present study, we aimed to develop and characterize oxaceprol-loaded poly-lactide-co-glycolide (PLGA) nanoparticles for intra-articular administration in osteoarthritis. PLGA nanoparticles were prepared by doubleemulsion solvent evaporation method. Meanwhile, a straightforward and generally applicable high performance liquid chromatography method was developed, and validated for the first time for the quantification of oxaceprol. To examine the drug carrying capacity of nanoparticles, varying amount of oxaceprol was entrapped into a constant amount of polymer matrix. Moreover, the efficacy of drug amount on nanoparticle characteristics such as particle size, zeta potential, morphology, drug entrapment, and in vitro drug release was investigated. Nanoparticle sizes were between 229 and 509 nm for different amount of oxaceprol with spherical smooth morphology. Encapsulation efficiency ranged between 39.73 and 63.83% by decreasing oxaceprol amount. The results of Fourier transform infrared and DSC showed absence of interaction between oxaceprol and PLGA. The in vitro drug release from these nanoparticles showed a sustained release of oxaceprol over 30 days. According to cell culture studies, oxaceprol-loaded nanoparticles had no cytotoxicity with high biocompatibility. This study was the first step of developing an intra-articular system in the treatment of osteoarthritis for the controlled release of oxaceprol. Our findings showed that these nanoparticles can be beneficial for an effective treatment of osteoarthritis avoiding side effects associated with oral administration. K E Y W O R D Sintra-articular injection, nanoparticle, osteoarthritis, oxaceprol, PLGA

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“…In addition, the size (d. nm) and zeta potential of 5Fu-loaded HPAE-PCL-b-MPEG nanoparticles were found to be about 44.81 ±16.73 nm ( Figure 6B) and +11.3 ±0.8 mV. Nanoparticles can be accumulated at the tumor region via enhanced permeability and retention effect if their size is less than 200 nm [9,33,34] and their positively charged surface allows an electrostatic interaction between negatively charged cellular membranes and positively charged nanoparticles [42]. Consequently, hydrophilic shell, nonspherical shape, size, and zeta potential value of nanoparticles predict that the circulation time of HPAE-PCL-b-MPEG nanoparticles in the blood is partially extended.…”

Section: Characterization Of 5fu-loaded Nanoparticlesmentioning

confidence: 96%

Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

et al. 2020

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An amphiphilic core/shell-type polymer-based drug carrier system (HPAE-PCLb-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)bpoly(ε-caprolactone) diblock polymers (MPEGb-PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, 1 H NMR, 13 C NMR, and GPC analysis. Monodisperse HPAE-PCLb-MPEG nanoparticles with dimensions of <200 nm and polydispersity index of <0.5 were prepared by nanoprecipitation method and characterized with SEM, particle size, and zeta potential analysis. 5-Fluorouracil was encapsulated within HPAE-PCLb-MPEG nanoparticles. In vitro drug release profiles and cytotoxicity of blank and 5-fluorouracil-loaded nanoparticles were examined against the human colon cancer HCT116 cell line. All results suggest that HPAE-PCLb-MPEG nanoparticles offer an alternative and effective drug nanocarrier system for drug delivery applications.

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pH sensitive functionalized hyperbranched polyester based nanoparticulate system for the receptor-mediated targeted cancer therapy

Cited by 13 publications

References 79 publications

<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>

<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

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pH sensitive functionalized hyperbranched polyester based nanoparticulate system for the receptor-mediated targeted cancer therapy

Cited by 13 publications

References 79 publications

<p>Green synthesis of multifunctional PEG-carboxylate &pi; back-bonded gold nanoconjugates for breast cancer treatment</p>

<p>Green synthesis of multifunctional PEG-carboxylate &pi; back-bonded gold nanoconjugates for breast cancer treatment</p>

Development and characterization of oxaceprol‐loaded poly‐lactide‐co‐glycolide nanoparticles for the treatment of osteoarthritis

Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery

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<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>

<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>