pH-Sensitive Cationic Copolymers of Different Macromolecular Architecture as Potential Dexamethasone Sodium Phosphate Delivery Systems

Georgieva, Dilyana; Kostova, Bistra; Ivanova, Sijka; Rachev, Dimitar; Tzankova, Virginia; Kondeva-Burdina, Magdalena; Christova, Darinka

doi:10.1002/jps.24059

Cited by 8 publications

(3 citation statements)

References 37 publications

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“…Notably, vibrational peaks at 1299 and 1103 cm −1 may be due to the phosphate anion (-PO) of DSP [66]. The -CF group axial deformation of DSP shows very small peaks at 989 and 891 cm −1 [67]. Moreover, blank and drug-loaded spectra of HP-β-CD-g-poly(AA)/gelatin hydrogels are almost similar.…”

Section: Solid-state Characterizationmentioning

confidence: 95%

In Vitro and Biological Characterization of Dexamethasone Sodium Phosphate Laden pH-Sensitive and Mucoadhesive Hydroxy Propyl β-Cyclodextrin-g-poly(acrylic acid)/Gelatin Semi-Interpenetrating Networks

Ajaz

Khan

Irfan

et al. 2022

Gels

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The current study reports the fabrication and biological evaluation of hydroxy propyl β-cyclodextrin-g-poly(acrylic acid)/gelatin (HP-β-CD-g-poly(AA)/gelatin) semi-interpenetrating networks (semi-IPN) for colonic delivery of dexamethasone sodium phosphate (DSP). The prepared hydrogels showed pH-dependent swelling and mucoadhesive properties. The mucoadhesive strength of hydrogels increased with an increasing concentration of gelatin. Based on the swelling and mucoadhesive properties, AG-1 was chosen as the optimized formulation (0.33% w/w of gelatin and 16.66% w/w of AA) for further analysis. FTIR revealed the successful development of a polymeric network without any interaction with DSP. SEM images revealed a slightly rough surface after drug loading. Drug distribution at the molecular level was confirmed by XRD. In vitro drug release assay showed pH-dependent release, i.e., a minute amount of DSP was released at a pH of 1.2 while 90.58% was released over 72 h at pH 7.4. The optimized formulation did not show any toxic effects on a rabbit’s vital organs and was also hemocompatible, thus confirming the biocompatible nature of the hydrogel. Conclusively, the prepared semi-IPN hydrogel possessed the necessary features, which can be exploited for the colonic delivery of DSP.

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Section: Solid-state Characterizationmentioning

confidence: 95%

In Vitro and Biological Characterization of Dexamethasone Sodium Phosphate Laden pH-Sensitive and Mucoadhesive Hydroxy Propyl β-Cyclodextrin-g-poly(acrylic acid)/Gelatin Semi-Interpenetrating Networks

Ajaz

Khan

Irfan

et al. 2022

Gels

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“…We developed cationic polyelectrolytes of different macromolecular structure using [2-(acryloyloxy)ethyl]trimethylammonium chloride (AETMAC), block or star shaped, and studied the complex formation with DSP. All copolymer structures showed high DSP loading efficiency and controlled the release process for a period of 24 h [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Conceptualization and Investigation of Multicomponent Polymer Networks as Prospective Corticosteroid Carriers

Georgieva

Alexandrova

Ivanova

et al. 2023

Gels

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Dexamethasone (DXM) is a highly potent and long-acting synthetic glucocorticoid with anti-inflammatory, anti-allergic, and immunosuppressive effects. However, the systemic application of DXM can cause undesirable side effects: sleep disorders, nervousness, heart rhythm disorders, heart attack, and others. In the present study, multicomponent polymer networks were developed as potential new platforms for the dermal application of dexamethasone sodium phosphate (DSP). First, a copolymer network (CPN) comprising hydrophilic segments of different chemical structures was synthesized by applying redox polymerization of dimethyl acrylamide onto poly(ethylene glycol) in the presence of poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker. On this basis, an interpenetrating polymer network structure (IPN) was obtained by introducing a second network of PEGDA-crosslinked poly(N-isopropylacrylamide). Multicomponent networks obtained were characterized by FTIR, TGA, and swelling kinetics in different solvents. Both CPN and IPN showed a high swelling degree in aqueous media (up to 1800 and 1200%, respectively), reaching the equilibrium swelling within 24 h. Additionally, IPN showed temperature-responsive swelling in an aqueous solution as the equilibrium swelling degree decreased considerably with an increase in the temperature. In order to evaluate the networks’ potential as drug carriers, swelling in DSP aqueous solutions of varied concentration was investigated. It was established that the amount of encapsulated DSP could be easily controlled by the concentration of drug aqueous solution. In vitro DSP release was studied in buffer solution (BS) with pH 7.4 at 37 °C. The results obtained during DSP loading and release experiments proved the feasibility of the developed multicomponent hydrophilic polymer networks as effective platforms for potential dermal application.

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“…Linear cationic polymers such as polyethyleneimine (PEI) and polydiallyldimethylammonium chloride (PDADMAC) have been used in EKC separations . Cationic latex nanoparticles have been synthesized by other means, but the application is often drug delivery rather than separation science .…”

Section: Introductionmentioning

confidence: 99%

Performance and selectivity of cationic nanoparticle pseudo‐stationary phases in electrokinetic chromatography

et al. 2016

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Electrokinetic chromatography (EKC) is a powerful analytical technique that uses an ionic pseudo-stationary phase (PSP) to separate neutral compounds. Although anionic surfactants are the most common choice for PSP, cationic latex nanoparticles are an attractive alternative. Reversible addition-fragmentation chain transfer (RAFT) polymerization was used to synthesize several types of diblock copolymers that self-assemble into latex nanoparticles, which were characterized by a variety of techniques including diffusion NMR. The performance of each nanoparticle as a PSP was studied by using a homologous series of ketones and linear solvation energy relationships (LSER) analysis. A cationic homopolymer coating was found to be necessary to prevent band broadening caused by analyte interactions with nanoparticles adsorbed to the capillary surface. No significant difference in methylene selectivity or LSER parameters was observed between nanoparticles with different cationic shells, but differences were observed between nanoparticles with different hydrophobic cores. Cationic latex nanoparticles behaved more like anionic latex nanoparticles than like cationic surfactants, suggesting that selectivity is primarily driven by the hydrophobic portion of a PSP. Cationic latex nanoparticles in combination with a homopolymer cationic capillary coating are an excellent choice for EKC analyses where an anodic electroosmotic flow is required.

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pH-Sensitive Cationic Copolymers of Different Macromolecular Architecture as Potential Dexamethasone Sodium Phosphate Delivery Systems

Cited by 8 publications

References 37 publications

In Vitro and Biological Characterization of Dexamethasone Sodium Phosphate Laden pH-Sensitive and Mucoadhesive Hydroxy Propyl β-Cyclodextrin-g-poly(acrylic acid)/Gelatin Semi-Interpenetrating Networks

In Vitro and Biological Characterization of Dexamethasone Sodium Phosphate Laden pH-Sensitive and Mucoadhesive Hydroxy Propyl β-Cyclodextrin-g-poly(acrylic acid)/Gelatin Semi-Interpenetrating Networks

Conceptualization and Investigation of Multicomponent Polymer Networks as Prospective Corticosteroid Carriers

Performance and selectivity of cationic nanoparticle pseudo‐stationary phases in electrokinetic chromatography

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