pH-sensitive biosystem based on laponite RD/chitosan/polyvinyl alcohol hydrogels for controlled delivery of curcumin to breast cancer cells

Jafari, Hessam; Namazi, Hassan

doi:10.1016/j.colsurfb.2023.113585

Cited by 18 publications

(3 citation statements)

References 49 publications

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“…Previous studies found that curcumin possesses a variety of pharmacological properties such as anti-tumor, antibacterial, anti-inflammatory and antioxidant effects. 52 , 53 Currently, two clinical trials show results. One of them is a phase II trial using curcumin in patients with advanced pancreatic cancer, which has been completed and the results are available (NCT00094445).…”

Section: Resultsmentioning

confidence: 99%

Analysis of Clinical Trials Using Anti-Tumor Traditional Chinese Medicine Monomers

Lv,

Liu,

Tang

et al. 2024

DDDT

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Section: Resultsmentioning

confidence: 99%

Analysis of Clinical Trials Using Anti-Tumor Traditional Chinese Medicine Monomers

Lv,

Liu,

Tang

et al. 2024

DDDT

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“…The LAP/chitosan (CS)/PVA hydrogels exhibit pH-responsive behavior, releasing 27.9% of curcumin in 12 h at pH 5.5 and 12.3% at pH 7.4, with cumulative releases of 48.5% and 18.5% over three days, respectively [ 11 ]. In vivo studies demonstrated lower cytotoxicity against cancer cells compared to free curcumin, confirming controlled drug release.…”

Section: Laponite ® Applicationsmentioning

confidence: 99%

“…In the field of drilling fluids, LAP is utilized for its ability to improve the stability and performance of drilling muds in oil and gas exploration operations [ 10 ]. The colloidal stability and biocompatibility of LAP are exploited in the medical field where it represents an ideal candidate for the formulation of controlled drug release systems [ 11 ]. Also, the large surface area and tunable surface chemistry of LAP make it a versatile platform for the fabrication of sensitive and selective sensing devices [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Brunchi,

Morariu

2024

Molecules

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Laponite® (LAP) is an intensively studied synthetic clay due to the versatility given by its layered structure, which makes it usable in various applications. This review describes the multifaceted properties and applications of LAP in aqueous dispersions and gel systems. The first sections of the review discuss the LAP structure and the interactions between clay discs in an aqueous medium under different conditions (such as ionic strength, pH, temperature, and the addition of polymers) in order to understand the function of clay in tailoring the properties of the designed material. Additionally, the review explores the aging phenomenon characteristic of LAP aqueous dispersions as well as the development of shake-gels by incorporating LAP. The second part shows the most recent studies on materials containing LAP with possible applicability in the drilling industry, cosmetics or care products industry, and biomedical fields. By elucidating the remarkable versatility and ease of integration of LAP into various matrices, this review underscores its significance as a key ingredient for the creation of next-generation materials with tailored functionalities.

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Development of a freshness indicator packaging system using cold atmospheric plasma on LLDPE–PVA with Laponite–anthocyanin biohybrid

Leandro,

Laroque,

Carciofi

et al. 2024

Polymer International

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This study developed a freshness indicator based on poly(vinyl alcohol) (PVA) and a biohybrid (BH) of Laponite® and anthocyanins adhered to linear low‐density polyethylene (LLDPE) using cold atmospheric plasma (CAP). LLDPE was treated with CAP for 0 to 300 s, which resulted in an increased surface energy, characterized by an important increase in its polar component up to 120 s of treatment, due to the formation of polar groups on the surface of LLDPE. No changes in mechanical properties and water vapor permeability of LLDPE were observed. LLDPE–PVA–BH films were more homogeneous if BH was added before the acidification of the film‐forming solution due to more negative zeta potential and lower particle size of BH in basic medium. Indicators made with BH were able to maintain color after 8 weeks of exposure to light, while those made with anthocyanin extract had fully degraded after 3 weeks. The freshness indicator's color changed from purple to blue and finally to green when exposed to ammonia hydroxide (30% NH3) and from purple to blue when exposed to a simulant liquid of spoiled meat (0.03% NH3). Similar color variance was observed when the indicator was applied to monitor shrimp freshness, changing from purple to blue when the shrimp pH reached pH 7.6. Thus, bilayer films of LLDPE–PVA and natural BH produced using CAP have potential food packaging applications. © 2024 Society of Chemical Industry.

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pH-sensitive biosystem based on laponite RD/chitosan/polyvinyl alcohol hydrogels for controlled delivery of curcumin to breast cancer cells

Cited by 18 publications

References 49 publications

Analysis of Clinical Trials Using Anti-Tumor Traditional Chinese Medicine Monomers

Analysis of Clinical Trials Using Anti-Tumor Traditional Chinese Medicine Monomers

Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Development of a freshness indicator packaging system using cold atmospheric plasma on LLDPE–PVA with Laponite–anthocyanin biohybrid

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