pH-sensitive and specific ligand-conjugated chitosan nanogels for efficient drug delivery

Liu, Xing; Fan, Yatong; Shen, Lijun; Yang, Chenxi; Li, Xiaoying; Ma, Yan; Qi, Lian-Yu; Cho, Ki-Hyun; Cho, Chong‐Su; Jiang, Hu‐Lin

doi:10.1016/j.ijbiomac.2019.08.237

Cited by 41 publications

(13 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitosan is used as a cationic polysaccharide. Chitosan, as a cationic polysaccharide, contains a large number of amino and hydroxyl groups in its molecular chain, which makes it PH sensitive [ 60 ]. The design of such PH stimuli-responsive nanohydrogels provides a new idea for drug slow release and delivery.…”

Section: Chitosan In Biomedical Applicationsmentioning

confidence: 99%

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Zhang

et al. 2022

Polymers

View full text Add to dashboard Cite

Chitosan is a biodegradable natural polymer derived from the exoskeleton of crustaceans. Because of its biocompatibility and non-biotoxicity, chitosan is widely used in the fields of medicine and agriculture. With the latest technology and technological progress, different active functional groups can be connected by modification, surface modification, or other configurations with various physical, chemical, and biological properties. These changes can significantly expand the application range and efficacy of chitosan polymers. This paper reviews the different uses of chitosan, such as catheter bridging to repair nerve broken ends, making wound auxiliaries, as tissue engineering repair materials for bone or cartilage, or as carriers for a variety of drugs to expand the volume or slow-release and even show potential in the fight against COVID-19. In addition, it is also discussed that chitosan in agriculture can improve the growth of crops and can be used as an antioxidant coating because its natural antibacterial properties are used alone or in conjunction with a variety of endophytic bacteria and metal ions. Generally speaking, chitosan is a kind of polymer material with excellent development prospects in medicine and agriculture.

show abstract

Section: Chitosan In Biomedical Applicationsmentioning

confidence: 99%

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Zhang

et al. 2022

Polymers

View full text Add to dashboard Cite

show abstract

“…Some characteristics of CS such as Mw, DD degree, viscosity and concentration of polymeric solution can significantly contribute to particle size distribution and also influence the thermo sensitive features of NGs. It was reported that the NG structure is depending on formulation type, either covalent or ionic crosslinking [53]. The -OH and -NH 2 groups can also form covalent bonds in the presence of a chemical linker [51].…”

Section: Chitosan Based Nanogels (Cs-ngs)mentioning

confidence: 99%

“…The positively charged surface of CS can complex with the negatively charges of gene to form stable polyplexes. The stability of polyplexes is correlated with the ability to protect DNA from nuclease degradation [53].…”

Section: Cs Based Nanocarriers For Gene Deliverymentioning

confidence: 99%

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

et al. 2021

View full text Add to dashboard Cite

In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on chitosan (CS) or chitosan derivatives are broadly investigated as promising nanocarriers due to their biodegradability, good biocompatibility, non-toxicity, low immunogenicity, great versatility and beneficial biological effects. CS, either alone or as composites, are suitable substrates in the fabrication of different types of products like hydrogels, membranes, beads, porous foams, nanoparticles, in-situ gel, microparticles, sponges and nanofibers/scaffolds. Currently, the CS based nanocarriers are intensely studied as controlled and targeted drug release systems for different drugs (anti-inflammatory, antibiotic, anticancer etc.) as well as for proteins/peptides, growth factors, vaccines, small DNA (DNAs) and short interfering RNA (siRNA). This review targets the latest biomedical approaches for CS based nanocarriers such as nanoparticles (NPs) nanofibers (NFs), nanogels (NGs) and chitosan coated liposomes (LPs) and their potential applications for medical and pharmaceutical fields. The advantages and challenges of reviewed CS based nanocarriers for different routes of administration (oral, transmucosal, pulmonary and transdermal) with reference to classical formulations are also emphasized.

show abstract

“…Therefore, many stimuli-responsive nanohydrogels have been designed and developed as controlled drug delivery systems. The physical or chemical structure of these intelligent nanohydrogels can effectively respond to environmental stimuli such as temperature [28,35,36], pH [37][38][39], redox potential [40][41][42], ionic strength [43,44] or the combination of these factors [45][46][47][48], to achieve the purpose of targeted and controlled drug release. In particular, redox responsive nanohydrogels have been intensively investigated as potential intracellular delivery systems [49].…”

Section: Introductionmentioning

confidence: 99%

Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox–Responsive Degradability for Intracellular Delivery

et al. 2021

View full text Add to dashboard Cite

A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery. In this study, we developed a novel redox responsive core-shell structure nanohydrogel prepared by a water in oil nanoemulsion method using two biocompatible synthetic polymers: vinyl sulfonated poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate)-polyethylene glycol-poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate) triblock copolymer, and thiolated hyaluronic acid. The influence on the nanohydrogel particle size and distribution of formulation parameters was investigated by a three-level full factorial design to optimize the preparation conditions. The surface and core-shell morphology of the nanohydrogel were observed by scanning electron microscope, transmission electron microscopy, and further confirmed by Fourier transform infrared spectroscopy and Raman spectroscopy from the standpoint of chemical composition. The redox-responsive biodegradability of the nanohydrogel in reducing environments was determined using glutathione as reducing agent. A nanohydrogel with particle size around 250 nm and polydispersity index around 0.1 is characterized by a thermosensitive shell which jellifies at body temperature and crosslinks at the interface of a redox-responsive hyaluronic acid core via the Michael addition reaction. The nanohydrogel showed good encapsulation efficiency for model macromolecules of different molecular weight (93% for cytochrome C, 47% for horseradish peroxidase, and 90% for bovine serum albumin), capacity to retain the peroxidase-like enzymatic activity (around 90%) of cytochrome C and horseradish peroxidase, and specific redox-responsive release behavior. Additionally, the nanohydrogel exhibited excellent cytocompatibility and internalization efficiency into macrophages. Therefore, the developed core-shell structure nanohydrogel can be considered a promising tool for the potential intracellular delivery of different pharmaceutical applications, including for cancer therapy.

show abstract

pH-sensitive and specific ligand-conjugated chitosan nanogels for efficient drug delivery

Cited by 41 publications

References 86 publications

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox–Responsive Degradability for Intracellular Delivery

Contact Info

Product

Resources

About