pH-responsive release of proteins from biocompatible and biodegradable reverse polymer micelles

Koyamatsu, Yuichi; Hirano, Taisuke; Kakizawa, Yasushi; Okano, Fumiyoshi; Takarada, Tohru; Maeda, Mizuo

doi:10.1016/j.jconrel.2013.10.035

Cited by 51 publications

(38 citation statements)

References 50 publications

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“…Nevertheless, protein and peptide delivery via the nonparenteral route are highly appealing due to their non-invasive nature and needs to be further addressed in the future. For other applications and indications intensive research efforts are already conducted resulting in highly sophisticated soft matter nanocarriers like charge conversional polyionic micelles (Lee et al, 2009) or stimuli-responsive polymeric micelles which release the payload depending on the environmental pH (Koyamatsu et al, 2014), temperature (Cuggino et al, 2011) or ionic strength (Lu et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers

Witting

Obst

Frieß

et al. 2015

Biotechnology Advances

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Section: Resultsmentioning

confidence: 99%

Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers

Witting

Obst

Frieß

et al. 2015

Biotechnology Advances

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“…In addition, the polymer becomes less hydrophobic with decreasing M w , and it is water soluble at 1,100 Da [27]. PLGA copolymers have a glass transition temperature (Tg) in the range of [45][46][47][48][49][50][51][52][53][54][55] C which is above the physiological temperature (37 C), thus they are normally glassy in nature mechanical, with sufficient strength for formulation development. It has been demonstrated that the Tg of a PLGA copolymer decreases with M w and lactide content [22].…”

Section: Micellementioning

confidence: 99%

“…On the other hand, nanosystems that are stable at acidic pHs while dissociate in neutral pHs can be of particular interest for oral delivery. Koyamatsu et al [47] formulated a reverse polymeric micelle (mean diameter: 100 nm) using the amphiphilic diblock copolymer PLGA-PEG for protein oral delivery. These micelles encapsulated with BSA and streptavidin showed no drug liberation at acidic pHs, while the encapsulated protein was released at neutral and basic conditions.…”

Section: Transferrinmentioning

confidence: 99%

Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

El-Hammadi¹,

Arias²

2015

Handbook of Nanoparticles

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Drug molecules often display little affinity for nonhealthy tissues and/or cells, leading to inefficiency, and high incidence of severe side effects. To face the problem, numerous strategies have been postulated, i.e., chemical modifications to the drug molecule, and proper engineering of drug nanocarriers. In this line, the introduction of poly(D,L-lactide-co-glycolide) nanoparticles in the drug delivery arena has been hypothesized to optimize drug biodistribution and concentration into the targeted site, thus improving the therapeutic effect while reducing the associated drug toxicity. Recent advances in the field have been devoted to the optimization of the in vivo fate and effectiveness of poly(D,L-lactide-co-glycolide)-based drug nanocarriers, i.e., by passive targeting strategies based on the functionalization of the particle surface with special biomolecules, and/or active targeting stratagems thanks to modifications leading to stimuliresponsive nanoparticles. In this chapter, we analyze the current state of the art and future perspectives in the formulation of poly(D,L-lactide-co-glycolide)-based nanomedicines against severe diseases.

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“…However, delivery of these drugs is limited because of parenteral administration and necessity of frequent injections due to their short half-life in human blood [1]. Preparation of biodegradable microspheres containing proteins and peptides has received much attention in recent years [2,3].…”

Section: Introductionmentioning

confidence: 99%

Alginate/κ-Carrageenan Microspheres and their Application for Protein Drugs Controlled Release

Kolesnyk¹,

Konovalova²,

Бурбан³

2015

ChChT

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Abstract. pH-Responsive microspheres were prepared and their feasibility as potential carriers for oral delivery of protein drugs was evaluated. The microspheres were prepared from the ionotropically-crosslinked mixture of sodium alginate and κ-carrageenan. The morphology and size of the microspheres were investigated. A model protein drug α-amylase was entrapped and in vitro drug release profiles were established. The preliminary investigation of the microspheres showed a consistent swelling pattern, high entrapment efficiency and sustained release profiles of the enzyme. All the results indicated that the alginate/κ-carrageenan microspheres could be potentially useful in drug delivery systems.

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pH-responsive release of proteins from biocompatible and biodegradable reverse polymer micelles

Cited by 51 publications

References 50 publications

Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers

Recent advances in topical delivery of proteins and peptides mediated by soft matter nanocarriers

Advanced Engineering Approaches in the Development of PLGA-Based Nanomedicines

Alginate/κ-Carrageenan Microspheres and their Application for Protein Drugs Controlled Release

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