pH-responsive ratiometric photoacoustic imaging of polyaniline nanoparticle-coated needle for targeted cancer biopsy

Choe, Ayoung; Qin, David; Yu, Anthony M.; Chung, Eunhyea; Jhunjhunwala, Anamik; Rose, Julian A.; Emelianov, Stanislav

doi:10.1016/j.pacs.2023.100500

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…As shown in Figure 4i, the quantitative results exhibited significant disparities in pH levels between healthy and ulcerated mice (2.32 ± 0.43 vs 4.81 ± 0.37; p < 0.0001), which were consistent with measurements obtained using a commercially available pH meter. These results showed the pH-responsive 151 which exhibited a good linear relationship between the PA signal ratio and pH value in a certain range (6.5−7.5) and was used for the detection of pH values in malignant tissues in vivo.…”

Section: Ratiometric Pa Imagingmentioning

confidence: 81%

“…These results showed the pH-responsive nanosensor was well-suited for long-term monitoring and tracking the changes of the gastrointestinal pH in vivo . Additionally, Emelianov et al developed a pH-responsive ratiometric PA probe based on PANI, which exhibited a good linear relationship between the PA signal ratio and pH value in a certain range (6.5–7.5) and was used for the detection of pH values in malignant tissues in vivo .…”

Section: Ratiometric Pa Imagingmentioning

confidence: 99%

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Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

Fu,

Yang,

Wang

et al. 2024

ACS Nano

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Dynamic variations in the concentration and abnormal distribution of endogenous biomarkers are strongly associated with multiple physiological and pathological states. Therefore, it is crucial to design imaging systems capable of realtime detection of dynamic changes in biomarkers for the accurate diagnosis and effective treatment of diseases. Recently, ratiometric imaging has emerged as a widely used technique for sensing and imaging of biomarkers due to its advantage of circumventing the limitations inherent to conventional intensity-dependent signal readout methods while also providing built-in self-calibration for signal correction. Here, the recent progress of ratiometric probes and their applications in sensing and imaging of biomarkers are outlined. Ratiometric probes are classified according to their imaging mechanisms, and ratiometric photoacoustic imaging, ratiometric optical imaging including photoluminescence imaging and self-luminescence imaging, ratiometric magnetic resonance imaging, and dual-modal ratiometric imaging are discussed. The applications of ratiometric probes in the sensing and imaging of biomarkers such as pH, reactive oxygen species (ROS), reactive nitrogen species (RNS), glutathione (GSH), gas molecules, enzymes, metal ions, and hypoxia are discussed in detail. Additionally, this Review presents an overview of challenges faced in this field along with future research directions.

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Section: Ratiometric Pa Imagingmentioning

confidence: 81%

Section: Ratiometric Pa Imagingmentioning

confidence: 99%

Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

Fu,

Yang,

Wang

et al. 2024

ACS Nano

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“…By leveraging nanomaterials like carbon nanotubes and nanowires, researchers have developed needle-type sensors with diameters on the nanoscale. These sensors exhibit exceptional sensitivity and can access previously unreachable spaces within biological tissues or industrial equipment [ 34 ].…”

Section: Summary and Prospectsmentioning

confidence: 99%

“…Reviewing the publications related to the high-frequency occurrence keywords, the following could be observed: (1) Manufacturing of needle-type sensors for detection equipment is the current research focus, especially in the field of bioengineering, such as monitoring blood sugar [ 31 ], skin humidity [ 32 ], and disease markers [ 33 ]. (2) Needles are mostly coated with nanoparticles, which have a high surface area enabling fast and reversible responses [ 34 ]. (3) Needle-type biosensors have attracted increasing attention, as it is the most mentioned type of sensor (268 counts) in the analysis, indicating broad prospects for development.…”

Section: Introductionmentioning

confidence: 99%

Two Decades' advancements and Research trends in needle-type Sensor technology: A scientometric analysis

Yang,

Xu,

et al. 2024

Heliyon

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Development of Nitroreductase‐Activatable Fluoroquinolone Prodrugs Exhibiting Attenuated Magnesium Ion Binding

Zhao,

Yadav,

Weng

et al. 2023

Helvetica Chimica Acta

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Fluoroquinolones such as levofloxacin and ciprofloxacin are potent antibiotics prescribed to treat various bacterial infections. Recent studies have also identified prominent examples as promising anti‐cancer agents. However, significant off‐target effects observed in human patients have precluded their wide‐spread clinical use. For instance, upon systemic administration, overt toxicity toward eukaryotic organelles (i.e., mitochondria) can result to the destruction of healthy tissue. Moreover, fluoroquinolones feature a β‐ketoacid motif which binds to and strips magnesium ions from cartilage, leading to rupture of the Achilles tendon. In this study, we have masked the β‐ketoacid of levofloxacin and ciprofloxacin (as well as two quinolones) with a nitroreductase (NTR)‐responsive warhead appended through a new self‐immolative prodrug linker developed by our group. The resulting β‐ketoester functional group was found to be remarkably resistant toward spontaneous hydrolysis, esterase activity, as well as other ester‐cleaving enzymatic systems. Further testing also reveal no cross‐reactivity against commonly encountered biologically relevant analytes (e.g., ROS and thiols). Importantly, we demonstrate that upon esterification, the binding toward magnesium ions was attenuated based on an in vitro fluorescent competition assay with the unmodified parent drug.

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pH-responsive ratiometric photoacoustic imaging of polyaniline nanoparticle-coated needle for targeted cancer biopsy

Cited by 5 publications

References 38 publications

Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

Activatable Probes for Ratiometric Imaging of Endogenous Biomarkers In Vivo

Two Decades' advancements and Research trends in needle-type Sensor technology: A scientometric analysis

Development of Nitroreductase‐Activatable Fluoroquinolone Prodrugs Exhibiting Attenuated Magnesium Ion Binding

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