pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects

Modulation of Aggregation‐Caused Quenching to Aggregation‐Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy

“…These observation indicated that free DOX might exert strong negative effect on the energy of the body while AIENPs loading and encapsulation can greatly reverse this trend to significantly increase its safety upon in vivo application. [13] Afterwards, the cytotoxicity of AIENPs/DOX in compared with free DOX was tested against HT29 cells. As shown in Figure 3A, the cytotoxicity effect of AIENPs/DOX was increased as a function of both time and concentrations.…”

Intelligent design of polymersomes for antibacterial and anticancer applications

“…As shown in Figure 10a, the hydrolysis of ortho esters at acidic condition and the subsequent increase in hydrophilicity of the P t NEA block result in the disassembly of polymersomes, thus rapidly releasing anticancer drugs. Albuquerque and co‐workers reported another type of pH‐responsive polymersomes self‐assembled from amphiphilic diblock copolymer poly( N ‐[2‐hydroxypropyl] methacrylamide)‐ block ‐poly(2‐(diisopropylamino)ethyl methacrylate) (PHPMA‐ b ‐PDPA) (Albuquerque et al, 2021). In this case, the rapid pH‐triggered release of anticancer drugs was realized by protonation of diisopropylamino groups at acidic condition and the subsequent increase in hydrophilicity of PDPA blocks (Figure 10b).…”

“…(b) Diisopropylamino group. Reprinted with permission from Albuquerque et al (2021), Copyright 2021 Elsevier.…”

Recent advances in mechanical force-responsive drug delivery systems

“…In recent years, smart drug delivery systems (DDSs) with the ability to control drug release precisely in time, location, and dosage, or with the ability to respond to physiological or external stimuli, have been extensively studied. 1 As a typical example, endogenous disease-specific environments, in terms of pH, 2,3 redox, 4,5 hypoxia 6,7 and enzymes, 8,9 or external signals, in terms of light, 10,11 temperature, 12,13 ultrasound, 14,15 and magnetic fields 16,17 have been widely explored to design intelligent or safe targeted drug delivery systems. 18 Among them, a DDS that responds to mechanical force stimuli, which has a wide range of sources in organisms and is of great significance in life activities, has recently attracted a lot of interest.…”