pH‐Responsive Nutraceutical–Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability

Guillet‐Nicolas, Rémy; Popat, Amirali; Bridot, Jean-Luc; Monteith, Gregory R.; Qiao, Shi Zhang; Kleitz, Freddy

doi:10.1002/ange.201208840

Cited by 88 publications

(26 citation statements)

References 54 publications

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“…Mesoporous silica nanomaterial (MSN) with stimuli‐responsive capping agents has been demonstrated as one of the most promising and high‐efficiency drug carriers due to its remarkable biocompatibility, high payload capacity, and in particular, the controllable drug release behavior . Among current MSN systems, various capping agents, such as organic molecules, carbohydrates, synthetic polymers, peptides, proteins, DNA/RNA, supramolecular assemblies, and inorganic nanoparticles, have been employed as the responsive “gatekeepers.” Despite these general prosperities, most of the gated systems, especially as used for in vivo cancer therapy, still have critical problems such as unpredictable toxicity of the capping agents as well as the scarcity of bioresponsiveness. [1a,9g] Therefore, new systems that are gated by capping agents with low or no potential risks and could also respond to internal biological stimuli are highly anticipated.…”

Section: Introductionmentioning

confidence: 99%

“…In the pioneering systems, efficient pH‐triggered drug release required either an alkaline condition (pH = 10)[8h,k] or a rather low pH value (3–4). [9d,f] Recently, the developments based on mildly acid‐responsive “gatekeepers,” such as ZnO or Fe 3 O 4 nanoparticles,[9e,j] Ca 3 (PO 4 ) 2 or CaCO 3 coatings,[9g,i,k] Zn 2+ –imidazol coordination polymer,[4e] cyclodextrin‐based assemblies,[8c,l] and proteins with pH‐cleavable linkers,[6f] are constantly emerging for controlled release of anticancer drugs. These efforts toward the introduction of internal biological stimuli greatly boosted the possibility of practical use of such MSNs systems for in vivo cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

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A Drug‐Self‐Gated Mesoporous Antitumor Nanoplatform Based on pH‐Sensitive Dynamic Covalent Bond

Zeng

Liu

Tao

et al. 2017

Adv Funct Materials

277

145

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To achieve on‐demand drug release, mesoporous silica nanocarriers as antitumor platforms generally need to be gated with stimuli‐responsive capping agents. Herein, a “smart” mesoporous nanocarrier that is gated by the drug itself through a pH‐sensitive dynamic benzoic–imine covalent bond is demonstrated. The new system, which tactfully bypasses the use of auxiliary capping agents, could also exhibit desirable drug release at tumor tissues/cells and enhanced tumor inhibition. Moreover, a facile dynamic PEGylation via benzoic–imine bond further endows the drug‐self‐gated nanocarrier with tumor extracellular pH‐triggered cell uptake and improves therapeutic efficiency in vivo. In short, the paradigm shift in capping agents here will simplify mesoporous nanomaterials as intelligent drug carriers for cancer therapy. Moreover, the self‐gated strategy in this work also shows general potential for self‐controlled delivery of natural biomolecules, for example, DNA/RNA, peptides, and proteins, due to their intrinsic amino groups.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Drug‐Self‐Gated Mesoporous Antitumor Nanoplatform Based on pH‐Sensitive Dynamic Covalent Bond

Zeng

Liu

Tao

et al. 2017

Adv Funct Materials

277

145

View full text Add to dashboard Cite

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“…Amid diverse modification processes, principally moving are schemes based on the use of biodegradable nutraceuticals, such as soy protein isolates (SPI) [ 186 ], β-lactoglobulin [ 147 ] or chitosan [ 145 , 187 ]. β-lactoglobulin is a whey protein, present in sheep and cow milk, and it is fully biodegradable and biocompatible.…”

Section: Oral Drug Delivery Using Mesoporous Silica Nanomaterialsmentioning

confidence: 99%

“…For example, Guillet-Nicolas et al used the benefits of MSNs with the advantages of the reasonably priced nutraceutical β-lactoglobulin, which is also a surplus product of the dairy industry. In this method, MSNs (MCM-48-type nanoparticles) functionalized with aminosilane were linked to succinylated β-lactoglobulin (in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide) and loaded with a drug molecule (ibuprofen, as a model drug) [ 147 ]. The resulting bioconjugates were tested as a novel pH-responsive oral drug delivery system.…”

Section: Oral Drug Delivery Using Mesoporous Silica Nanomaterialsmentioning

confidence: 99%

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Mesoporous Silica Nanomaterials: Versatile Nanocarriers for Cancer Theranostics and Drug and Gene Delivery

et al. 2019

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Mesoporous silica nanomaterials (MSNs) have made remarkable achievements and are being thought of by researchers as materials that can be used to effect great change in cancer therapies, gene delivery, and drug delivery because of their optically transparent properties, flexible size, functional surface, low toxicity profile, and very good drug loading competence. Mesoporous silica nanoparticles (MSNPs) show a very high loading capacity for therapeutic agents. It is well known that cancer is one of the most severe known medical conditions, characterized by cells that grow and spread rapidly. Thus, curtailing cancer is one of the greatest current challenges for scientists. Nanotechnology is an evolving field of study, encompassing medicine, engineering, and science, and it has evolved over the years with respect to cancer therapy. This review outlines the applications of mesoporous nanomaterials in the field of cancer theranostics, as well as drug and gene delivery. MSNs employed as therapeutic agents, as well as their importance and future prospects in the ensuing generation of cancer theranostics and drug and therapeutic gene delivery, are discussed herein. Thus, the use of mesoporous silica nanomaterials can be seen as using one stone to kill three birds.

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Mesoporous Silica Nanoparticles: Selective Surface Functionalization for Optimal Relaxometric and Drug Loading Performances

Bouchoucha

C.‐Gaudreault

Fortin

et al. 2014

Adv Funct Materials

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Mesoporous silica nanoparticles (MSNs) have emerged as promising biomaterials for drug delivery and cell tracking applications, for which MRI is the medical imaging modality of choice. In this contribution, MRI contrast agents (DTPA‐Gd) and polyethylene glycol (PEG) are grafted selectively at the surface of MSNs, in order to achieve optimal relaxometric and drug loading performances. In fact, DTPA and PEG grafting procedures reported until now, have resulted in significant pore obstruction, which is detrimental to the drug delivery function of MSNs. This usually induces a dramatic decrease in surface area and pore volume, thus limiting drug loading capacity. Therefore, these molecules must be selectively grafted at the outer surface of MSNs. In this study, 3D pore network MSNs (MCM‐48‐type) are synthesized and functionalized with a straightforward and efficient grafting procedure in which DTPA and PEG are selectively grafted at the outer surface of MSNs. No pore blocking is observed, and more than 90% of surface area, pore volume and pore diameter are retained. The thus‐treated particles are colloidally stable in SBF and cell culture media, they are not cytotoxic and they have high drug loading capacity. Upon labeling with Gd, the nanoparticle suspensions have strong relaxometric properties (r2/r1 = 1.47, r1 = 23.97 mM−1 s−1), which confers a remarkable positive contrast enhancement potential to the compound. The particles could serve as efficient drug carriers, as demonstrated with a model of daunorubicin submitted to physiological conditions. The selective nanoparticle surface grafting procedures described in the present article represent a significant advance in the design of high colloidal stability silica‐based vectors with high drug loading capacity, which could provide novel theranostic nanocompounds.

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pH‐Responsive Nutraceutical–Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability

Cited by 88 publications

References 54 publications

A Drug‐Self‐Gated Mesoporous Antitumor Nanoplatform Based on pH‐Sensitive Dynamic Covalent Bond

A Drug‐Self‐Gated Mesoporous Antitumor Nanoplatform Based on pH‐Sensitive Dynamic Covalent Bond

Mesoporous Silica Nanomaterials: Versatile Nanocarriers for Cancer Theranostics and Drug and Gene Delivery

Mesoporous Silica Nanoparticles: Selective Surface Functionalization for Optimal Relaxometric and Drug Loading Performances

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