pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles

Sharpe, Lindsey A.; Ramirez, Julia E. Vela; Haddadin, Olivia M.; Ross, Kathleen A.; Narasimhan, Balaji; Peppas, Nicholas A.

doi:10.1021/acs.biomac.7b01590

Cited by 33 publications

(35 citation statements)

References 66 publications

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“…Stimuli-response in polymers materials is generally related to changes in the polymer chain conformation [ 6 ] that can be induced by temperature [ 7 , 8 ], pH [ 9 ], light [ 10 ], proteins [ 11 ], ionic strength [ 12 ], and so forth or combinations thereof [ 13 , 14 ]. Among these stimuli, pH has many potential applications because it can be used as an intrinsic trigger in processes where variations in pH occur as a consequence of changes that need a particular response.…”

Section: Introductionmentioning

confidence: 99%

Grafting with RAFT—gRAFT Strategies to Prepare Hybrid Nanocarriers with Core-shell Architecture

et al. 2020

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Stimuli-responsive polymer materials are used in smart nanocarriers to provide the stimuli-actuated mechanical and chemical changes that modulate cargo delivery. To take full advantage of the potential of stimuli-responsive polymers for controlled delivery applications, these have been grafted to the surface of mesoporous silica particles (MSNs), which are mechanically robust, have very large surface areas and available pore volumes, uniform and tunable pore sizes and a large diversity of surface functionalization options. Here, we explore the impact of different RAFT-based grafting strategies on the amount of a pH-responsive polymer incorporated in the shell of MSNs. Using a “grafting to” (gRAFT-to) approach we studied the effect of polymer chain size on the amount of polymer in the shell. This was compared with the results obtained with a “grafting from” (gRAFT-from) approach, which yield slightly better polymer incorporation values. These two traditional grafting methods yield relatively limited amounts of polymer incorporation, due to steric hindrance between free chains in “grafting to” and to termination reactions between growing chains in “grafting from.” To increase the amount of polymer in the nanocarrier shell, we developed two strategies to improve the “grafting from” process. In the first, we added a cross-linking agent (gRAFT-cross) to limit the mobility of the growing polymer and thus decrease termination reactions at the MSN surface. On the second, we tested a hybrid grafting process (gRAFT-hybrid) where we added MSNs functionalized with chain transfer agent to the reaction media containing monomer and growing free polymer chains. Our results show that both modifications yield a significative increase in the amount of grafted polymer.

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Section: Introductionmentioning

confidence: 99%

Grafting with RAFT—gRAFT Strategies to Prepare Hybrid Nanocarriers with Core-shell Architecture

et al. 2020

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“…(f) MCT4 siRNA处理及未处理下, PC3细胞中ROS的产生. (g) 不同处理条件下的荷瘤小鼠及肿瘤组织图 [53] (网络版彩图) [55] (网络版彩图) [65] , 已广泛应用于纳米医学的相关研…”

Section: 引言unclassified

Chemodynamic therapy: integration of Fenton chemistry and biomedicine

Liu¹,

Chen²,

Bu³

2020

Sci. Sin.-Chim

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Metal-organic frameworks-based nanocatalytic medicine for chemodynamic therapy SCIENCE CHINA Materials Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy Science Bulletin 65, 564 (2020); Biocompatible CuO-decorated carbon nanoplatforms for multiplexed imaging and enhanced antitumor efficacy via combined photothermal therapy/chemodynamic therapy/chemotherapy SCIENCE CHINA Materials 63, 1818 (2020); Fabrication of smart polymeric nanovectors to amplify intracellular oxidative stress for chemodynamic therapy

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“…[28] The spectrum of thin-film interference changes with the film thickness is also commonly seen in daily life, just like the various iridescent colors induced by the nonuniform thickness of a soap bubble or oil-covered water. [29] Responsive hydrogels are capable of large deformation triggered by external stimuli such as solvent, [30] pH, [22,31] temperature [32] and humidity. [11,33] Hydrogel as a cross-linked hydrophilic polymer network is known as superabsorbent.…”

Section: (5 Of 8)mentioning

confidence: 99%

Hydrogel Interferometry for Ultrasensitive and Highly Selective Chemical Detection

et al. 2018

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Developing ultrasensitive chemical sensors with small scale and fast response through simple design and low‐cost fabrication is highly desired but still challenging. Herein, a simple and universal sensing platform based on a hydrogel interferometer with femtomol‐level sensitivity in detecting (bio)chemical molecules is demonstrated. A unique local concentrating effect (up to 109 folds) in the hydrogel induced by the strong analyte binding and large amount of ligands, combined with the signal amplification effect by optical interference, endows this platform with an ultrahigh sensitivity, specifically 10−14m for copper ions and 1.0 × 10−11 mg mL−1 for glycoprotein with 2–4 order‐of‐magnitude enhancement. The specific chemical reactions between selected ligands and target analytes provide high selectivity in detecting complex fluids. This universal principle with broad chemistry, simple physics, and modular design allows for high performance in detecting wide customer choices of analytes, including metal ions and proteins. The scale of the sensor can be down to micrometer size. The nature of the soft gel makes this platform transparent, flexible, stretchable, and compatible with a variety of substrates, showing high sensing stability and robustness after 200 cycles of bending or stretching. The outstanding sensing performance grants this platform great promise in broad practical applications.

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pH-Responsive Microencapsulation Systems for the Oral Delivery of Polyanhydride Nanoparticles

Cited by 33 publications

References 66 publications

Grafting with RAFT—gRAFT Strategies to Prepare Hybrid Nanocarriers with Core-shell Architecture

Grafting with RAFT—gRAFT Strategies to Prepare Hybrid Nanocarriers with Core-shell Architecture

Chemodynamic therapy: integration of Fenton chemistry and biomedicine

Hydrogel Interferometry for Ultrasensitive and Highly Selective Chemical Detection

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