pH-responsive gold nanoclusters-based nanoprobes for lung cancer targeted near-infrared fluorescence imaging and chemo-photodynamic therapy

Xia, Fangfang; Hou, Wenxiu; Zhang, Chunlei; Zhi, Xiao; Cheng, Jin; Fuente, Jesús M. de la; Song, Jie; Cui, Daxiang

doi:10.1016/j.actbio.2017.12.034

Cited by 83 publications

(43 citation statements)

References 47 publications

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“…The efficacy of PDT using Au NC-based photosensitizers can be enhanced by combination with other therapeutic modalities, such as conjugates with organic photosensitizers, chemo-T, RT, PTT, and targeted imaging. In this context, we focused on Au NC-based multimodal synergistic therapies, particularly PTT, 88,[126][127][128] chemo-T, [129][130][131] and conjugates with organic photosensitizers. 132,133 He et al assembled Au 25 (Capt) 18 onto mesoporous silicacoated Nd 3+ -sensitized up-conversion NPs (UCNPs@MS-Au 25 ) to form a multifunctional platform for photoacoustic (PA) imaging and dual phototherapy (PTT/PDT).…”

Section: Basic Principle Of Photosensitization For Pdtmentioning

confidence: 99%

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

2020

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Section: Basic Principle Of Photosensitization For Pdtmentioning

confidence: 99%

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

2020

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“…68 Several studies have taken advantage of the acidic pH within tumour tissues for drug release. [69][70][71] Wu et al used RGD (arginine-glycine-aspartic acid) peptides to specifically target αvβ integrins overexpressed on the surface of cancer cells. 69 The authors synthesised 14 nm AuNPs and functionalised them with 5ALA, which is converted to the photosensitiser PpIX, via an acid sensitive hydrazone bond, with RGD peptides and with a zwitteronic peptide sequence that provides 'stealth-like' properties to avoid protein adsorption.…”

Section: Peptidesmentioning

confidence: 99%

“…70 Other important receptors involved in cancer progression, metastasis and angiogenesis are matrix metalloproteinases (MMP), especially MMP2. 71…”

Section: Peptidesmentioning

confidence: 99%

Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

Calavia

Bruce

Pérez‐García

et al. 2018

Photochem Photobiol Sci

117

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Gold nanoparticles (AuNPs) have been extensively studied within biomedicine due to their biocompatibility and low toxicity. In particular, AuNPs have been widely used to deliver photosensitiser agents for photodynamic therapy (PDT) of cancer. Here we review the state-of-the-art for the functionalisation of the gold nanoparticle surface with both photosensitisers and targeting ligands for the active targeting of cancer cell surface receptors. From the initial use of the AuNPs as a simple carrier of the photosensitiser for PDT, the field has significantly advanced to include: the use of PEGylated modification to provide aqueous compatibility and stealth properties for in vivo use; gold metal-surface enhanced singlet oxygen generation; functionalisation of the AuNP surface with biological ligands to specifically target over-expressed receptors on the surface of cancer cells and; the creation of nanorods and nanostars to enable combined PDT and photothermal therapies. These versatile AuNPs have significantly enhanced the efficacy of traditional photosensitisers for both in vitro and in vivo cancer therapy. From this review it is apparent that AuNPs have an important future in the treatment of cancer.

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“…Gold nanoclusters (AuNCs) have gained growing interest recently, due to their unique properties and various potential applications including bioimaging, biolabeling, sensing, and therapy . They are composed of several up to tens of gold atoms, giving rise to ultrasmall sized structures of less than 2 nm .…”

Section: Introductionmentioning

confidence: 99%

NIR‐Emitting Gold Nanoclusters–Modified Gelatin Nanoparticles as a Bioimaging Agent in Tissue

El‐Sayed

Trouillet

Clasen

et al. 2019

Adv Healthcare Materials

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Gold nanocluster (AuNC) synthesis using a well‐distinguished polymer for nanoparticle‐mediated drug delivery paves the way for developing efficient theranostics based on pharmaceutically accepted materials. Gelatin‐stabilized AuNCs are synthesized and modified by glutathione for tuning the emission spectra. Addition of silver ions enhances the fluorescence, reaching also high quantum yield (26.7%). A simplified model can be proposed describing the nanoclusters' properties–structure relationship based on X‐ray photoelectron spectroscopy data and synthesis sequence. Furthermore, these modifications improve fluorescence stability toward pH changes and enzymatic degradation, offering different AuNCs for various applications. The impact of nanocluster formation on gelatin structure integrity is investigated by Fourier transform infrared spectrometry and matrix‐assisted laser desorption/ionization time of flight mass spectroscopy, being important to further formulate gelatin nanoparticles (GNPs). The 218 nm‐sized NPs show no cytotoxicity up to 600 µg mL−1 and are imaged in skin, as a challenging autofluorescent tissue, by confocal microscopy, when transcutaneously delivered using dissolving microneedles. Linear unmixing allows simultaneous imaging of AuNCs–GNPs and skin with accurate signal separation. This underlines the great potential for bioimaging of this system to better understand nanomaterials' behavior in tissue. Additionally, it is drug delivery system also potentially serving as a theranostic system.

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pH-responsive gold nanoclusters-based nanoprobes for lung cancer targeted near-infrared fluorescence imaging and chemo-photodynamic therapy

Cited by 83 publications

References 47 publications

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

Photo/electrocatalysis and photosensitization using metal nanoclusters for green energy and medical applications

Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

NIR‐Emitting Gold Nanoclusters–Modified Gelatin Nanoparticles as a Bioimaging Agent in Tissue

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