pH-Responsive Dual Drug-Loaded Nanocarriers Based on Poly (2-Ethyl-2-Oxazoline) Modified Black Phosphorus Nanosheets for Cancer Chemo/Photothermal Therapy

Gao, Nansha; Xing, Chenyang; Wang, Haifei; Feng, Liwen; Zeng, Xiaowei; Mei, Lin; Peng, Zhengchun

doi:10.3389/fphar.2019.00270

Cited by 51 publications

(74 citation statements)

References 57 publications

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“…The drugs are partly exposed to the outer environment so external triggers can easily interfere with the drug-βCD interaction, causing drug release. This conventional βCD-based drug delivery platform exhibited a significantly slow drug release rate at low pH [37][38][39][40]. However, the drug release of DL-CNPs was not the same as other βCD-possessing nanoparticles due to its unique structure.…”

Section: Loading and External Stimuli-trigger Release Of Doxmentioning

confidence: 99%

Dual pH- and GSH-Responsive Degradable PEGylated Graphene Quantum Dot-Based Nanoparticles for Enhanced HER2-Positive Breast Cancer Therapy

Van

Hong

et al. 2020

Nanomaterials

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Dual stimuli-responsive degradable carbon-based nanoparticles (DS-CNPs) conjugated with Herceptin (HER) and polyethylene glycol (PEG) have been designed for the treatment of HER2-positive breast cancer. Each component has been linked through disulfide linkages that are sensitive to glutathione in a cancer microenvironment. β-cyclodextrin (β-CD) on the surface of DS-CNPs formed an inclusion complex (DL-CNPs) with doxorubicin (DOX) at a high loading capacity of 5.3 ± 0.4%. In response to a high level of glutathione (GSH) and low pH in a tumor environment, DL-CNPs were rapidly degraded and released DOX in a controlled manner via disruption of host–guest inclusion. These novel DL-CNPs exhibited high cellular uptake with low toxicity, which induced the efficient inhibition of antitumor activity both in vitro and in vivo. Cell viability, confocal laser scanning microscopy, and animal studies indicate that DL-CNPs are a great platform with a synergistically enhanced antitumor effect from the dual delivery of HER and DOX in DL-CNPs.

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Section: Loading and External Stimuli-trigger Release Of Doxmentioning

confidence: 99%

Dual pH- and GSH-Responsive Degradable PEGylated Graphene Quantum Dot-Based Nanoparticles for Enhanced HER2-Positive Breast Cancer Therapy

Van

Hong

et al. 2020

Nanomaterials

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“…reported a DDS for synergistic combination therapy based on electrostatic interaction between BPNs and DOX, with a high DOX loading capacity of 950 wt%. [ 41 ] In Gao et al.’s two studies, [ 46,66 ] the DOX loading of 300% was achieved on bare BPNs, and Wu et al.’s study attained 233% loading. [ 67 ] The as‐prepared BPNs‐DOX greatly improved the transport efficiency of DOX in vivo, reduced drug loss before activity began, and improved biocompatibility and antitumor efficiency.…”

Section: Construction Of Bp‐based Ddssmentioning

confidence: 99%

Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy

et al. 2021

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Cancer has been one of the major threats to the lives of human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order to improve the treatment efficiency of drugs, an intelligent drug delivery system (DDS) is considered as a promising solution strategy. Due to their special structure and large specific surface area, 2D materials are considered to be a good platform for drug delivery. Black phosphorus (BP), as a new star of the 2D family, is recommended to have the potential to construct DDS by virtue of its outstanding photothermal therapy (PTT), photodynamic therapy (PDT), and biodegradable properties. This tutorial review is intended to provide an introduction of the current advances in BP‐based DDSs for cancer therapy, which covers topics from its construction, classified by the types of platforms, to the stimuli‐responsive controlled drug release. Moreover, their cancer therapy applications including mono‐, bi‐, and multi‐modal synergistic cancer therapy as well as the research of biocompatibility are also discussed. Finally, the current status and future prospects of BP‐based DDSs for cancer therapy are summarized.

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“…Oxide: AlO x ; [13a,26a,26b] SiO 2 ; [26c] Ionic liquids; [27] Hexagonal supramolecular networks; [28] Hexagonal boron nitride; [29] Graphene; [29,30] Organic MLs; [31] Polymers: PPV; [32] PMMA; [33] PILs; [34] PEG-NH 2 ; [35] PEG; [36] PEOz; [37] PLGA; [18b] PDA; [35b,37] PPMS-EPO; [39] Biomaterials: Cellulose; [17b] liposomes. [40] Liquid protection NMP, ethanol, acetone, DMF, DMSO, CHP, ionic liquid.…”

Section: Surface Passivation Layermentioning

confidence: 99%

Black Phosphorus: Degradation Mechanism, Passivation Method, and Application for In Situ Tissue Regeneration

Xie

Abbasi

Xiao

et al. 2020

Adv Materials Inter

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have been already applied for the restoration. [2] During the development of the treatments, the term "tissue engineering" was advanced in the 1980s, in which the biological and engineering principles are combined to fabricate functional replacements for regenerating injured tissues. [3] However, the classical tissue engineering strategy needs a lot of time and much laborious effort for extensive cell expansion steps. In the past few decades, a new idea, known as in situ tissue regeneration (ISTR), was introduced. ISTR means that the host endogenous stem cells or tissuespecific progenitor cells are guided to the location of trauma for tissue recovery in vivo by implanting specific biomaterials system without complicated in vitro manipulation. [4] Many biomaterials, including natural biomaterials, [5] synthetic biopolymers, [6] and bioceramics, [7] have been widely applied for ISTR. The degradation rate of materials is crucial to the successful ISTR, as a rapid degradation may influence the properties of implanted biomaterial composites, for example, causing a mechanical failure. From the other side, if the composite degrades too sluggishly, an inflammation might occur and impair the recovery of damaged tissue. [8] Along with the rapid development of nanomaterials, the 2D materials [9] have attracted ever-increasing interest in tissue regeneration, owing to their remarkable optical properties, biocompatibility, large specific surface area, and high payload of drugs and agents. However, the ISTR application area is limited by the poor biodegradability of conventional 2D nanomaterials. Attributed to the excellent biodegradation ability, 2D black phosphorus (BP) has stepped into people's horizon, which shows more promising potentials in organism restoration over other 2D materials. The bulk form of BP was first synthesized by Bridgman in 1914 from white phosphorus with a high-pressure synthesis method. [10] Nevertheless, the BP crystal did not gain much attention due to the small band gap and the difficulty of controlling the material quality, [11] until a monolayer (ML) of BP crystal was introduced by several research groups in 2014. [12] The 2D nanomaterial of BP, also known as phosphorene, has several different properties from other 2D materials, e.g., graphene. One different major point is that the lone pair electron makes phosphorus atom be an active chemical adsorption position for oxygen molecules. With the rapid increase of BP surface, phosphorene will chemically decompose very quickly Nanomaterials have attracted ever-increasing interest in tissue regeneration in the past few decades. As an emerging 2D layered nanomaterial, black phosphorus shows more promising potentials in organism restoration than other 2D materials, attributed to its extraordinary biodegradation ability, remarkable optical properties, and high payload of drugs and agents. The degradation products, i.e., phosphate, can be adsorbed by tissues for specific regeneration such as bone, yet the excessive degradation rate of black phosphorus wil...

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pH-Responsive Dual Drug-Loaded Nanocarriers Based on Poly (2-Ethyl-2-Oxazoline) Modified Black Phosphorus Nanosheets for Cancer Chemo/Photothermal Therapy

Cited by 51 publications

References 57 publications

Dual pH- and GSH-Responsive Degradable PEGylated Graphene Quantum Dot-Based Nanoparticles for Enhanced HER2-Positive Breast Cancer Therapy

Dual pH- and GSH-Responsive Degradable PEGylated Graphene Quantum Dot-Based Nanoparticles for Enhanced HER2-Positive Breast Cancer Therapy

Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy

Black Phosphorus: Degradation Mechanism, Passivation Method, and Application for In Situ Tissue Regeneration

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